troglitazone has been researched along with Experimental Neoplasms in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine the tumor-promoting effect of troglitazone (TRG), a novel thiazolidinedione insulin-sensitizing agent, on splenic hemangiosarcomas in rasH2 mice, histopathological and molecular analyses were performed in the spleen of female rasH2 mice fed a diet containing 6,000 or 0 ppm TRG for 16 weeks after 1,000 or 0 mg/kg urethane (UR) initiation." | 7.74 | Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane. ( Dewa, Y; Hasumi, K; Jin, M; Matsumoto, S; Mitsumori, K; Nishimura, J; Saekusa, Y, 2008) |
| "To examine the tumor-promoting effect of troglitazone (TRG), a novel thiazolidinedione insulin-sensitizing agent, on splenic hemangiosarcomas in rasH2 mice, histopathological and molecular analyses were performed in the spleen of female rasH2 mice fed a diet containing 6,000 or 0 ppm TRG for 16 weeks after 1,000 or 0 mg/kg urethane (UR) initiation." | 3.74 | Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane. ( Dewa, Y; Hasumi, K; Jin, M; Matsumoto, S; Mitsumori, K; Nishimura, J; Saekusa, Y, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vesci, L | 1 |
| Milazzo, FM | 1 |
| Stasi, MA | 1 |
| Pace, S | 1 |
| Manera, F | 1 |
| Tallarico, C | 1 |
| Cini, E | 1 |
| Petricci, E | 1 |
| Manetti, F | 1 |
| De Santis, R | 1 |
| Giannini, G | 1 |
| Andela, VB | 1 |
| Altuwaijri, S | 1 |
| Wood, J | 1 |
| Rosier, RN | 1 |
| Jin, M | 1 |
| Matsumoto, S | 1 |
| Dewa, Y | 1 |
| Nishimura, J | 1 |
| Saekusa, Y | 1 |
| Hasumi, K | 1 |
| Mitsumori, K | 1 |
3 other studies available for troglitazone and Experimental Neoplasms
| Article | Year |
|---|---|
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dos | 2018 |
Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.
Topics: Adenocarcinoma, Bronchiolo-Alveolar; Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptos | 2005 |
Extremely weak tumor-promoting effect of troglitazone on splenic hemangiosarcomas in rasH2 mice induced by urethane.
Topics: Angiogenic Proteins; Animals; Body Weight; Carcinogens; Cell Proliferation; Chromans; Female; Gene E | 2008 |