troglitazone and Endotoxemia studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

Research Excerpts

Excerpt	Relevance	Reference
"Troglitazone treatment had no significant effect on LPS-induced plasma TNF, glucose, or nitric oxide levels in WT or PPARalpha null mice at any of the time points examined."	5.31	Pretreatment with troglitazone decreases lethality during endotoxemia in mice. ( Gimble, J; Gipson, J; Gonzalez, F; Hill, M; Hoffhines, A; Johnson, J; Novosad, B; Peters, J; Reynolds, K, 2002)
"Troglitazone treatment had no significant effect on LPS-induced plasma TNF, glucose, or nitric oxide levels in WT or PPARalpha null mice at any of the time points examined."	1.31	Pretreatment with troglitazone decreases lethality during endotoxemia in mice. ( Gimble, J; Gipson, J; Gonzalez, F; Hill, M; Hoffhines, A; Johnson, J; Novosad, B; Peters, J; Reynolds, K, 2002)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

troglitazone and Endotoxemia

Research Excerpts

Research

Studies (1)

Authors

Other Studies

Authors	Studies
Reynolds, K	1
Novosad, B	1
Hoffhines, A	1
Gipson, J	1
Johnson, J	1
Peters, J	1
Gonzalez, F	1
Gimble, J	1
Hill, M	1