troglitazone has been researched along with Electron Transport Chain Deficiencies, Mitochondrial in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone does not cause hepatotoxicity in normal healthy rodents, but it produces mitochondrial injury in vitro at high concentrations." | 5.34 | Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. ( Boelsterli, UA; Latchoumycandane, C; Ong, MM, 2007) |
| "Troglitazone does not cause hepatotoxicity in normal healthy rodents, but it produces mitochondrial injury in vitro at high concentrations." | 1.34 | Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. ( Boelsterli, UA; Latchoumycandane, C; Ong, MM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bavli, D | 1 |
| Prill, S | 1 |
| Ezra, E | 1 |
| Levy, G | 1 |
| Cohen, M | 1 |
| Vinken, M | 1 |
| Vanfleteren, J | 1 |
| Jaeger, M | 1 |
| Nahmias, Y | 1 |
| Ong, MM | 1 |
| Latchoumycandane, C | 1 |
| Boelsterli, UA | 1 |
| Jaeschke, H | 1 |
3 other studies available for troglitazone and Electron Transport Chain Deficiencies, Mitochondrial
| Article | Year |
|---|---|
Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction.
Topics: Chromans; Hep G2 Cells; Humans; Lab-On-A-Chip Devices; Liver; Mitochondria, Liver; Mitochondrial Dis | 2016 |
Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities.
Topics: Aconitate Hydratase; Animals; Chemical and Drug Induced Liver Injury; Chromans; Disease Models, Anim | 2007 |
Troglitazone hepatotoxicity: are we getting closer to understanding idiosyncratic liver injury?
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromans; Disease Models, Animal; Humans; Hypoglyce | 2007 |