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troglitazone and Colorectal Cancer

troglitazone has been researched along with Colorectal Cancer in 9 studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Research Excerpts

ExcerptRelevanceReference
"In this study, we identified a new mechanism for the anti-proliferation of HCT15 colorectal cancer cells by troglitazone (TRO)."7.71Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. ( Ahn, Y; Choi, KY; Kim, HI; Kim, JA; Oh, JW; Oh, SY; Park, KS, 2002)
" In this report, we show that ATF3 mRNA and protein expression are up-regulated in HCT-116 human colorectal cancer cells following treatment with NSAIDs, troglitazone, diallyl disulfide, and resveratrol."3.73The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3). ( Alston-Mills, B; Bottone, FG; Eling, TE; Ishibashi, M; Kim, JS; Moon, Y, 2005)
"In this study, we identified a new mechanism for the anti-proliferation of HCT15 colorectal cancer cells by troglitazone (TRO)."3.71Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. ( Ahn, Y; Choi, KY; Kim, HI; Kim, JA; Oh, JW; Oh, SY; Park, KS, 2002)
"Troglitazone (TGZ) is a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand that has pro-apoptotic activity in human colon cancer."1.32Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity. ( Baek, SJ; Eling, TE; Hsi, LC; Wilson, LC, 2003)
"The development of colorectal cancer, one of the most frequent cancers, is influenced by prostaglandins and fatty acids."1.30Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. ( Auwerx, J; Briggs, M; Chen, I; Desreumaux, P; Fruchart, JC; Geboes, K; Heyman, R; Lefebvre, AM; Najib, J, 1998)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's5 (55.56)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
van Noort, V1
Schölch, S1
Iskar, M1
Zeller, G1
Ostertag, K1
Schweitzer, C1
Werner, K1
Weitz, J1
Koch, M1
Bork, P1
Schwartz, B1
Algamas-Dimantov, A1
Hertz, R1
Nataf, J1
Kerman, A1
Peri, I1
Bar-Tana, J1
Baek, SJ1
Wilson, LC1
Hsi, LC1
Eling, TE2
Sabatino, L1
Casamassimi, A1
Peluso, G1
Barone, MV1
Capaccio, D1
Migliore, C1
Bonelli, P1
Pedicini, A1
Febbraro, A1
Ciccodicola, A1
Colantuoni, V1
Bottone, FG1
Moon, Y1
Kim, JS1
Alston-Mills, B1
Ishibashi, M1
Seed, B1
Lefebvre, AM1
Chen, I1
Desreumaux, P1
Najib, J1
Fruchart, JC1
Geboes, K1
Briggs, M1
Heyman, R1
Auwerx, J1
Sarraf, P1
Mueller, E1
Smith, WM1
Wright, HM1
Kum, JB1
Aaltonen, LA1
de la Chapelle, A1
Spiegelman, BM1
Eng, C1
Kim, JA1
Park, KS1
Kim, HI1
Oh, SY1
Ahn, Y1
Oh, JW1
Choi, KY1

Other Studies

9 other studies available for troglitazone and Colorectal Cancer

ArticleYear
Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling.
    Cancer research, 2014, Oct-15, Volume: 74, Issue:20

    Topics: Animals; Antineoplastic Agents; Chromans; Citalopram; Colorectal Neoplasms; Gene Expression Profilin

2014
Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4alpha.
    International journal of cancer, 2009, Mar-01, Volume: 124, Issue:5

    Topics: Animals; Caco-2 Cells; Chromans; Colorectal Neoplasms; Hepatocyte Nuclear Factor 4; HT29 Cells; Huma

2009
Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
    The Journal of biological chemistry, 2003, Feb-21, Volume: 278, Issue:8

    Topics: 3' Untranslated Regions; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Division; Chromans; C

2003
A novel peroxisome proliferator-activated receptor gamma isoform with dominant negative activity generated by alternative splicing.
    The Journal of biological chemistry, 2005, Jul-15, Volume: 280, Issue:28

    Topics: Alternative Splicing; Animals; Blotting, Western; Bromodeoxyuridine; Caco-2 Cells; Cell Nucleus; Cel

2005
The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3).
    Molecular cancer therapeutics, 2005, Volume: 4, Issue:5

    Topics: Activating Transcription Factor 3; Allyl Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal

2005
PPARgamma and colorectal carcinoma: conflicts in a nuclear family.
    Nature medicine, 1998, Volume: 4, Issue:9

    Topics: Adenomatous Polyposis Coli; Animals; Chromans; Colorectal Neoplasms; Humans; Mice; Receptors, Cytopl

1998
Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice.
    Nature medicine, 1998, Volume: 4, Issue:9

    Topics: Adenocarcinoma; Animals; beta Catenin; Chromans; Colorectal Neoplasms; Cyclooxygenase 2; Cytoskeleta

1998
Loss-of-function mutations in PPAR gamma associated with human colon cancer.
    Molecular cell, 1999, Volume: 3, Issue:6

    Topics: Amino Acid Substitution; Binding Sites; Chromans; Colorectal Neoplasms; Dimerization; DNA-Binding Pr

1999
Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells.
    Cancer letters, 2002, May-28, Volume: 179, Issue:2

    Topics: Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Nucleus; Chromans; Colorectal Neoplasms; C

2002