troglitazone has been researched along with Cardiac Diseases in 4 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, DA | 1 |
| Johnson, DE | 1 |
| Park, BK | 1 |
| Nightingale, SL | 1 |
| Zhou, YT | 1 |
| Grayburn, P | 1 |
| Karim, A | 1 |
| Shimabukuro, M | 1 |
| Higa, M | 1 |
| Baetens, D | 1 |
| Orci, L | 1 |
| Unger, RH | 1 |
| Yao, L | 1 |
| Mizushige, K | 1 |
| Noma, T | 1 |
| Murakami, K | 1 |
| Ohmori, K | 1 |
| Matsuo, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Quantification of Intramyocardial Lipid by Proton Magnetic Resonance Spectroscopy[NCT00469911] | 18 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants first had MRS spectroscopy then the MRS spectroscopy images were compared to endomyocardial biopsy (NCT00469911)
Timeframe: 2 to 10 days
| Intervention | correlation co-efficient (Number) |
|---|---|
| Heart Transplant Patients | 0.97 |
4 other studies available for troglitazone and Cardiac Diseases
| Article | Year |
|---|---|
Editorial overview: safety of drugs can never be absolute.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Chromans; | 2006 |
From the Food and Drug Administration.
Topics: Appetite Depressants; Chemical and Drug Induced Liver Injury; Chromans; Drug Labeling; Fenfluramine; | 1997 |
Lipotoxic heart disease in obese rats: implications for human obesity.
Topics: Age Factors; Animals; Apoptosis; Blood Glucose; Body Weight; Chromans; DNA Fragmentation; Echocardio | 2000 |
Troglitazone decreases collagen accumulation in prediabetic stage of a type II diabetic rat model.
Topics: Animals; Chromans; Collagen; Diabetes Mellitus, Type 2; Heart Diseases; Hypoglycemic Agents; Male; R | 2000 |