Page last updated: 2024-11-05

troglitazone and Cardiac Diseases

troglitazone has been researched along with Cardiac Diseases in 4 studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's3 (75.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smith, DA1
Johnson, DE1
Park, BK1
Nightingale, SL1
Zhou, YT1
Grayburn, P1
Karim, A1
Shimabukuro, M1
Higa, M1
Baetens, D1
Orci, L1
Unger, RH1
Yao, L1
Mizushige, K1
Noma, T1
Murakami, K1
Ohmori, K1
Matsuo, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Quantification of Intramyocardial Lipid by Proton Magnetic Resonance Spectroscopy[NCT00469911]18 participants (Actual)Interventional2005-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Correlation Co-efficient Between MRS Spectroscopy and Endomyocardial Biopsy in Heart Transplant Participants

Participants first had MRS spectroscopy then the MRS spectroscopy images were compared to endomyocardial biopsy (NCT00469911)
Timeframe: 2 to 10 days

Interventioncorrelation co-efficient (Number)
Heart Transplant Patients0.97

Other Studies

4 other studies available for troglitazone and Cardiac Diseases

ArticleYear
Editorial overview: safety of drugs can never be absolute.
    Current opinion in drug discovery & development, 2006, Volume: 9, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Chromans;

2006
From the Food and Drug Administration.
    JAMA, 1997, Dec-03, Volume: 278, Issue:21

    Topics: Appetite Depressants; Chemical and Drug Induced Liver Injury; Chromans; Drug Labeling; Fenfluramine;

1997
Lipotoxic heart disease in obese rats: implications for human obesity.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-15, Volume: 97, Issue:4

    Topics: Age Factors; Animals; Apoptosis; Blood Glucose; Body Weight; Chromans; DNA Fragmentation; Echocardio

2000
Troglitazone decreases collagen accumulation in prediabetic stage of a type II diabetic rat model.
    Heart (British Cardiac Society), 2000, Volume: 84, Issue:2

    Topics: Animals; Chromans; Collagen; Diabetes Mellitus, Type 2; Heart Diseases; Hypoglycemic Agents; Male; R

2000