Page last updated: 2024-11-05

troglitazone and Carcinoma

troglitazone has been researched along with Carcinoma in 3 studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.

Research Excerpts

ExcerptRelevanceReference
"We previously reported that the PPARgamma agonist troglitazone (TRO) inhibits proliferation and induces apoptosis in human MCF-7 breast carcinoma cells."7.72Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. ( Blaschke, F; Bruemmer, D; Herle, AJ; Hsueh, WA; Law, RE; Yin, F, 2004)
"Troglitazone and 15dPGJ2 inhibit growth of prostate and bladder carcinoma cell lines through different mechanisms and the effects of both agents are PPARgamma-independent."3.73PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. ( Chaffer, CL; Thomas, DM; Thompson, EW; Williams, ED, 2006)
"We previously reported that the PPARgamma agonist troglitazone (TRO) inhibits proliferation and induces apoptosis in human MCF-7 breast carcinoma cells."3.72Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. ( Blaschke, F; Bruemmer, D; Herle, AJ; Hsueh, WA; Law, RE; Yin, F, 2004)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yin, F1
Bruemmer, D1
Blaschke, F1
Hsueh, WA1
Law, RE1
Herle, AJ1
Chaffer, CL1
Thomas, DM1
Thompson, EW1
Williams, ED1
Toyota, M1
Miyazaki, Y1
Kitamura, S1
Nagasawa, Y1
Kiyohara, T1
Shinomura, Y1
Matsuzawa, Y1

Other Studies

3 other studies available for troglitazone and Carcinoma

ArticleYear
Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells.
    Oncogene, 2004, Jun-03, Volume: 23, Issue:26

    Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Cell Cycle; Chromans; Enzyme Inhibito

2004
PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma.
    BMC cancer, 2006, Mar-06, Volume: 6

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Carcinoma, Transitional Cell; Caspase 3; Caspase 7; Cas

2006
Peroxisome proliferator-activated receptor gamma reduces the growth rate of pancreatic cancer cells through the reduction of cyclin D1.
    Life sciences, 2002, Feb-15, Volume: 70, Issue:13

    Topics: Alitretinoin; Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Carcinoma; Cell

2002