troglitazone has been researched along with Carcinoma, Transitional Cell in 2 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone and 15dPGJ2 inhibit growth of prostate and bladder carcinoma cell lines through different mechanisms and the effects of both agents are PPARgamma-independent." | 3.73 | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. ( Chaffer, CL; Thomas, DM; Thompson, EW; Williams, ED, 2006) |
| "Troglitazone treatment increased expression of two cyclin-dependent kinase inhibitors, p21(WAF1/CIP1) and p16(INK4), and reduced cyclin D1 expression, consistent with G1 arrest." | 1.30 | Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death. ( Breyer, MD; Breyer, RM; Davis, L; Guan, YF; Zhang, YH, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chaffer, CL | 1 |
| Thomas, DM | 1 |
| Thompson, EW | 1 |
| Williams, ED | 1 |
| Guan, YF | 1 |
| Zhang, YH | 1 |
| Breyer, RM | 1 |
| Davis, L | 1 |
| Breyer, MD | 1 |
2 other studies available for troglitazone and Carcinoma, Transitional Cell
| Article | Year |
|---|---|
PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Carcinoma, Transitional Cell; Caspase 3; Caspase 7; Cas | 2006 |
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Carcinoma, Transitional Cell; Carrier Proteins; Cell | 1999 |