troglitazone has been researched along with Bone Loss, Osteoclastic in 5 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thus, TZDs may suppress bone resorption in diabetic patients and prevent bone loss." | 1.30 | Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro. ( Fujita, T; Fukumoto, S; Miyamoto, M; Okazaki, R; Takeuchi, Y; Tanaka, K; Toriumi, M, 1999) |
| "All the bone resorption markers, BALP and ALP were significantly decreased." | 1.30 | Short-term treatment with troglitazone decreases bone turnover in patients with type 2 diabetes mellitus. ( Fujita, T; Fukumoto, S; Hirota, Y; Miura, M; Okazaki, R; Taguchi, M; Takeuchi, A; Tanaka, K; Toriumi, M, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yan, J | 1 |
| Li, B | 1 |
| Chen, JW | 1 |
| Jiang, SD | 1 |
| Jiang, LS | 1 |
| Takeuchi, Y | 2 |
| Watanabe, S | 1 |
| Ishii, G | 1 |
| Takeda, S | 1 |
| Nakayama, K | 1 |
| Fukumoto, S | 3 |
| Kaneta, Y | 1 |
| Inoue, D | 1 |
| Matsumoto, T | 1 |
| Harigaya, K | 1 |
| Fujita, T | 3 |
| Okazaki, R | 3 |
| Toriumi, M | 2 |
| Miyamoto, M | 1 |
| Tanaka, K | 2 |
| Miura, M | 1 |
| Taguchi, M | 1 |
| Hirota, Y | 1 |
| Takeuchi, A | 1 |
1 review available for troglitazone and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
[Skeletal effects of thiazolidinediones].
Topics: Adipocytes; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Cells, Cultured; Chromans; Dia | 2000 |
4 other studies available for troglitazone and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Spinal cord injury causes bone loss through peroxisome proliferator-activated receptor-γ and Wnt signalling.
Topics: Adipogenesis; Anilides; Animals; Bone and Bones; Bone Density; Bone Resorption; Cell Differentiation | 2012 |
Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.
Topics: Aging; Animals; Base Sequence; Bone Development; Bone Marrow Cells; Bone Morphogenetic Proteins; Bon | 2002 |
Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro.
Topics: Acid Phosphatase; Adipocytes; Animals; Bone Marrow Cells; Bone Resorption; Calcitriol; Cell Differen | 1999 |
Short-term treatment with troglitazone decreases bone turnover in patients with type 2 diabetes mellitus.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Biomarkers; Blood Glucose; Bone and Bones; Bone Remod | 1999 |