troglitazone has been researched along with Bladder Cancer in 6 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone (TZ) is a synthetic ligand of peroxisome proliferator-activated receptor-γ, and it can induce apoptosis and autophagy in a variety of cancer cells." | 5.40 | The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. ( Chen, T; Jiang, X; Xi, Z; Yan, S; Yang, X, 2014) |
| "Troglitazone and 15dPGJ2 inhibit growth of prostate and bladder carcinoma cell lines through different mechanisms and the effects of both agents are PPARgamma-independent." | 3.73 | PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. ( Chaffer, CL; Thomas, DM; Thompson, EW; Williams, ED, 2006) |
| "Troglitazone (TZ) is a synthetic ligand of peroxisome proliferator-activated receptor-γ, and it can induce apoptosis and autophagy in a variety of cancer cells." | 1.40 | The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. ( Chen, T; Jiang, X; Xi, Z; Yan, S; Yang, X, 2014) |
| "Troglitazone treatment increased expression of two cyclin-dependent kinase inhibitors, p21(WAF1/CIP1) and p16(INK4), and reduced cyclin D1 expression, consistent with G1 arrest." | 1.30 | Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death. ( Breyer, MD; Breyer, RM; Davis, L; Guan, YF; Zhang, YH, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mehus, AA | 1 |
| Bergum, N | 1 |
| Knutson, P | 1 |
| Shrestha, S | 1 |
| Zhou, XD | 1 |
| Garrett, SH | 1 |
| Sens, DA | 1 |
| Sens, MA | 1 |
| Somji, S | 1 |
| Yan, S | 1 |
| Yang, X | 1 |
| Chen, T | 1 |
| Xi, Z | 1 |
| Jiang, X | 1 |
| Yoshimura, R | 1 |
| Matsuyama, M | 1 |
| Segawa, Y | 1 |
| Hase, T | 1 |
| Mitsuhashi, M | 1 |
| Tsuchida, K | 1 |
| Wada, S | 1 |
| Kawahito, Y | 1 |
| Sano, H | 1 |
| Nakatani, T | 1 |
| Chaffer, CL | 1 |
| Thomas, DM | 1 |
| Thompson, EW | 1 |
| Williams, ED | 1 |
| Guan, YF | 1 |
| Zhang, YH | 1 |
| Breyer, RM | 1 |
| Davis, L | 1 |
| Breyer, MD | 1 |
| Nakashiro, KI | 1 |
| Hayashi, Y | 1 |
| Kita, A | 1 |
| Tamatani, T | 1 |
| Chlenski, A | 1 |
| Usuda, N | 1 |
| Hattori, K | 1 |
| Reddy, JK | 1 |
| Oyasu, R | 1 |
6 other studies available for troglitazone and Bladder Cancer
| Article | Year |
|---|---|
Activation of PPARγ and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells.
Topics: Animals; Arsenites; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Down-Regulation; ErbB R | 2020 |
The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells.
Topics: Adenylate Kinase; Apoptosis; Autophagy; Blotting, Western; Cell Line, Tumor; Chromans; Humans; Necro | 2014 |
Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists.
Topics: Aged; Cell Division; Chromans; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistoch | 2003 |
PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Carcinoma, Transitional Cell; Caspase 3; Caspase 7; Cas | 2006 |
Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in human transitional bladder cancer and its role in inducing cell death.
Topics: Alitretinoin; Antineoplastic Agents; Apoptosis; Carcinoma, Transitional Cell; Carrier Proteins; Cell | 1999 |
Role of peroxisome proliferator-activated receptor gamma and its ligands in non-neoplastic and neoplastic human urothelial cells.
Topics: Aged; Blotting, Western; Cell Division; Cell Line; Chromans; Dose-Response Relationship, Drug; Human | 2001 |