troglitazone has been researched along with Bile Duct Obstruction in 7 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone has been reported to be beneficial in a small group of patients with nonalcoholic steatohepatitis (NASH)." | 5.31 | Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus. ( Angulo, P; Lindor, KD, 2001) |
| "Troglitazone sulfate (TGZS) is the major metabolite of troglitazone (TGZ), an antidiabetic agent, and thought to be a cause of the cholestasis induced by TGZ." | 3.74 | Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect. ( Enokizono, J; Kusuhara, H; Sugiyama, Y, 2007) |
| "Rosiglitazone was discontinued, and the patient was treated with prednisone, azathioprine, and ursodiol." | 1.31 | Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone. ( Azar, R; Banner, B; Bird, S; Bonkovsky, HL; Szabo, G, 2002) |
| "Troglitazone has been reported to be beneficial in a small group of patients with nonalcoholic steatohepatitis (NASH)." | 1.31 | Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus. ( Angulo, P; Lindor, KD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Bonkovsky, HL | 1 |
| Azar, R | 1 |
| Bird, S | 1 |
| Szabo, G | 1 |
| Banner, B | 1 |
| Masubuchi, Y | 1 |
| Enokizono, J | 1 |
| Kusuhara, H | 1 |
| Sugiyama, Y | 1 |
| Herrine, SK | 1 |
| Choudhary, C | 1 |
| Angulo, P | 1 |
| Lindor, KD | 1 |
| Kostrubsky, VE | 1 |
| Vore, M | 1 |
| Kindt, E | 1 |
| Burliegh, J | 1 |
| Rogers, K | 1 |
| Peter, G | 1 |
| Altrogge, D | 1 |
| Sinz, MW | 1 |
1 review available for troglitazone and Bile Duct Obstruction
| Article | Year |
|---|---|
Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: a review.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cholestasis; Chromans; Cytochrome P-450 CYP3A; Glut | 2006 |
6 other studies available for troglitazone and Bile Duct Obstruction
| Article | Year |
|---|---|
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Severe cholestatic hepatitis caused by thiazolidinediones: risks associated with substituting rosiglitazone for troglitazone.
Topics: Alkaline Phosphatase; Chemical and Drug Induced Liver Injury; Cholestasis; Chromans; Female; Humans; | 2002 |
Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; | 2007 |
Severe hepatotoxicity associated with troglitazone.
Topics: Cholestasis; Chromans; Diabetes Mellitus, Type 1; Fatal Outcome; Female; Humans; Hypoglycemic Agents | 1999 |
Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus.
Topics: Adult; Chemical and Drug Induced Liver Injury; Cholestasis; Chromans; Diabetes Mellitus, Type 1; Fat | 2001 |
The effect of troglitazone biliary excretion on metabolite distribution and cholestasis in transporter-deficient rats.
Topics: Animals; Animals, Genetically Modified; Area Under Curve; Bile; Bile Acids and Salts; Bilirubin; Bio | 2001 |