troglitazone has been researched along with Astrocytoma in 3 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, its expression in brain tumors has not been studied." | 1.31 | Expression of PPARgamma and its ligand-dependent growth inhibition in human brain tumor cell lines. ( Fujieda, M; Kato, M; Nagaya, T; Saito, K; Seo, H; Yoshida, J, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kambe, A | 1 |
| Iguchi, G | 1 |
| Moon, Y | 1 |
| Kamitani, H | 1 |
| Watanabe, T | 1 |
| Eling, TE | 1 |
| Wu, L | 1 |
| Eftekharpour, E | 1 |
| Davies, GF | 1 |
| Roesler, WJ | 1 |
| Juurlink, BH | 1 |
| Kato, M | 1 |
| Nagaya, T | 1 |
| Fujieda, M | 1 |
| Saito, K | 1 |
| Yoshida, J | 1 |
| Seo, H | 1 |
3 other studies available for troglitazone and Astrocytoma
| Article | Year |
|---|---|
Regulation of EP4 expression via the Sp-1 transcription factor: inhibition of expression by anti-cancer agents.
Topics: Antineoplastic Agents; Astrocytoma; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; | 2008 |
Troglitazone selectively inhibits glyoxalase I gene expression.
Topics: Animals; Antioxidants; Astrocytoma; Cell Culture Techniques; Cells, Cultured; Chromans; Gene Express | 2001 |
Expression of PPARgamma and its ligand-dependent growth inhibition in human brain tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Astrocytoma; Blotting, Northern; Brain Neoplasms; Cell Division; C | 2002 |