troglitazone has been researched along with Albuminuria in 9 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Albuminuria: The presence of albumin in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone, a newly developed thiazolidinedione derivative, has been shown to ameliorate microalbuminuria in diabetic animal model and in human diabetic nephropathy in short-term studies." | 9.09 | Effect of troglitazone on urinary albumin excretion and serum type IV collagen concentrations in Type 2 diabetic patients with microalbuminuria or macroalbuminuria. ( Ebihara, L; Koide, H; Nakamura, T; Sekizuka, K; Shimada, N; Suzuki, S; Ushiyama, C, 2001) |
| "Troglitazone ameliorated microalbuminuria in diabetic nephropathy." | 9.08 | Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy. ( Arai, K; Hori, M; Imano, E; Kajimoto, Y; Kanda, T; Motomura, M; Nakatani, Y; Nishida, T; Yamasaki, Y, 1998) |
| "We studied the effect of troglitazone, a new oral antidiabetic agent that potentiates insulin action and reduces insulin resistance, on albuminuria in streptozotocin (STZ)-treated diabetic rats." | 7.69 | Troglitazone (CS-045) ameliorates albuminuria in streptozotocin-induced diabetic rats. ( Fujii, M; Hasegawa, G; Kondo, M; Nakano, K; Shigeta, H; Takemura, R; Yamaguchi, M, 1997) |
| "Troglitazone, a newly developed thiazolidinedione derivative, has been shown to ameliorate microalbuminuria in diabetic animal model and in human diabetic nephropathy in short-term studies." | 5.09 | Effect of troglitazone on urinary albumin excretion and serum type IV collagen concentrations in Type 2 diabetic patients with microalbuminuria or macroalbuminuria. ( Ebihara, L; Koide, H; Nakamura, T; Sekizuka, K; Shimada, N; Suzuki, S; Ushiyama, C, 2001) |
| "Troglitazone ameliorated microalbuminuria in diabetic nephropathy." | 5.08 | Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy. ( Arai, K; Hori, M; Imano, E; Kajimoto, Y; Kanda, T; Motomura, M; Nakatani, Y; Nishida, T; Yamasaki, Y, 1998) |
| "We studied the effect of troglitazone, a new oral antidiabetic agent that potentiates insulin action and reduces insulin resistance, on albuminuria in streptozotocin (STZ)-treated diabetic rats." | 3.69 | Troglitazone (CS-045) ameliorates albuminuria in streptozotocin-induced diabetic rats. ( Fujii, M; Hasegawa, G; Kondo, M; Nakano, K; Shigeta, H; Takemura, R; Yamaguchi, M, 1997) |
| "Thus, diabetic nephropathy is currently the number one cause of end-stage renal disease in the Western world." | 2.43 | Protection of the kidney by thiazolidinediones: an assessment from bench to bedside. ( Bakris, GL; Sarafidis, PA, 2006) |
| "Troglitazone was able to prevent not only diabetic glomerular hyperfiltration and albuminuria, but an increase in mRNA expression of extracellular matrix proteins and transforming growth factor-beta1 in glomeruli of diabetic rats, without changing blood glucose levels." | 1.31 | Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. ( Haneda, M; Isshiki, K; Kikkawa, R; Koya, D; Maeda, S; Sugimoto, T, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Inukai, T | 1 |
| Takanashi, K | 1 |
| Tayama, K | 1 |
| Aso, Y | 1 |
| Takemura, Y | 1 |
| Yotsumoto, T | 1 |
| Naitoh, T | 1 |
| Kanaki, T | 1 |
| Matsuda, M | 1 |
| Tsuruzoe, N | 1 |
| Sarafidis, PA | 1 |
| Bakris, GL | 1 |
| Fujii, M | 1 |
| Takemura, R | 1 |
| Yamaguchi, M | 1 |
| Hasegawa, G | 1 |
| Shigeta, H | 1 |
| Nakano, K | 1 |
| Kondo, M | 1 |
| Imano, E | 1 |
| Kanda, T | 1 |
| Nakatani, Y | 1 |
| Nishida, T | 1 |
| Arai, K | 1 |
| Motomura, M | 1 |
| Kajimoto, Y | 1 |
| Yamasaki, Y | 1 |
| Hori, M | 1 |
| Isshiki, K | 1 |
| Haneda, M | 1 |
| Koya, D | 1 |
| Maeda, S | 1 |
| Sugimoto, T | 1 |
| Kikkawa, R | 1 |
| Janka, HU | 1 |
| Nakamura, T | 1 |
| Ushiyama, C | 1 |
| Suzuki, S | 1 |
| Shimada, N | 1 |
| Sekizuka, K | 1 |
| Ebihara, L | 1 |
| Koide, H | 1 |
| Yamashita, H | 1 |
| Nagai, Y | 1 |
| Takamura, T | 1 |
| Nohara, E | 1 |
| Kobayashi, K | 1 |
2 reviews available for troglitazone and Albuminuria
| Article | Year |
|---|---|
Protection of the kidney by thiazolidinediones: an assessment from bench to bedside.
Topics: Albuminuria; Animals; Blood Pressure; Chromans; Diabetes Mellitus, Type 2; Diabetic Nephropathies; E | 2006 |
[Glitazones. Profile of a new class of substances].
Topics: Albuminuria; Animals; Anticholesteremic Agents; Chromans; Cytochrome P-450 Enzyme System; Diabetes M | 2001 |
3 trials available for troglitazone and Albuminuria
| Article | Year |
|---|---|
High glucose concentrations abolish the superoxide dismutase response of leukocytes to ascorbic acid or troglitazone in type 2 diabetes mellitus.
Topics: Aged; Albuminuria; Antioxidants; Ascorbic Acid; Chromans; Diabetes Mellitus, Type 2; Diabetic Nephro | 2002 |
Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy.
Topics: Aged; Albuminuria; Blood Glucose; Blood Pressure; C-Peptide; Cholesterol; Cholesterol, HDL; Chromans | 1998 |
Effect of troglitazone on urinary albumin excretion and serum type IV collagen concentrations in Type 2 diabetic patients with microalbuminuria or macroalbuminuria.
Topics: Albuminuria; Animals; Blood Pressure; Chromans; Collagen; Creatinine; Diabetes Mellitus, Type 2; Dia | 2001 |
4 other studies available for troglitazone and Albuminuria
| Article | Year |
|---|---|
A novel peroxisome proliferator-activated receptor (PPAR)gamma agonist, NIP-222, reduces urinary albumin excretion in streptozotocin-diabetic mice independent of PPARgamma activation.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressure; Body | 2003 |
Troglitazone (CS-045) ameliorates albuminuria in streptozotocin-induced diabetic rats.
Topics: Albuminuria; Animals; Chromans; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Rats; Ra | 1997 |
Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats.
Topics: Albuminuria; Animals; Chromans; Diabetes Mellitus, Experimental; Diglycerides; Extracellular Matrix | 2000 |
Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat.
Topics: Albuminuria; Animals; Basement Membrane; Blood Glucose; Blood Pressure; Body Weight; Chromans; Creat | 2002 |