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troglitazone and Aging

troglitazone has been researched along with Aging in 10 studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Troglitazone, a newly developed oral antidiabetic agent, improves hyperglycemia, and has been reported to improve insulin resistance and to decrease hepatic glucose production in diabetic animals."7.69Effect of troglitazone, a new oral antidiabetic agent, on fructose-induced insulin resistance. ( Higa, S; Ishikawa, K; Mimura, G; Murakami, K; Takasu, N; Yagi, N, 1995)
"Troglitazone treatment did not increase ARC NPY gene expression either after a 72 h fast and re-feeding for 2 weeks (Experiment 1) or immediately after a 72 h fast (Experiment 2)."5.31Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. ( Marck, BT; Matsumoto, AM; Wolden-Hanson, T, 2002)
"To examine the effect of chronic oral administration of troglitazone on the age-related changes of insulin resistance, plasma CCK levels, and pancreatic growth in normal rats."3.71Troglitazone stimulates pancreatic growth in normal rats. ( Jia, DM; Otsuki, M, 2002)
" We found that these rats exhibit reduced food intake and body weight gain associated with decreased hypothalamic neuropeptide Y (NPY) gene expression in the arcuate nucleus (ARC), both during ad-libitum feeding and after a 72-h fast."3.70Aging and the neuroendocrine regulation of reproduction and body weight. ( Gruenewald, DA; Marck, BT; Matsumoto, AM; Naai, MA; Wolden-Hanson, T, 2000)
"Troglitazone, a newly developed oral antidiabetic agent, improves hyperglycemia, and has been reported to improve insulin resistance and to decrease hepatic glucose production in diabetic animals."3.69Effect of troglitazone, a new oral antidiabetic agent, on fructose-induced insulin resistance. ( Higa, S; Ishikawa, K; Mimura, G; Murakami, K; Takasu, N; Yagi, N, 1995)
"Troglitazone has been shown to improve insulin sensitivity and thereby exert hypoglycemic effects in various animal models and humans with insulin resistance and diabetes."1.31Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes. ( Akiyama, T; Fukumitsu, KI; Jia, DM; Nakamura, H; Otsuki, M; Tabaru, A, 2000)
"Troglitazone treatment significantly increased pancreatic wet weight and protein, DNA, and enzyme contents compared with those in the control rats."1.31Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats. ( Akiyama, T; Fukumitsu, KI; Jia, DM; Otsuki, M; Tabaru, A, 2001)
"Troglitazone treatment did not increase ARC NPY gene expression either after a 72 h fast and re-feeding for 2 weeks (Experiment 1) or immediately after a 72 h fast (Experiment 2)."1.31Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. ( Marck, BT; Matsumoto, AM; Wolden-Hanson, T, 2002)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (20.00)18.2507
2000's7 (70.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dao, LT1
Park, EY1
Hwang, OK1
Cha, JY1
Jun, HS1
Takeuchi, Y1
Watanabe, S1
Ishii, G1
Takeda, S1
Nakayama, K1
Fukumoto, S1
Kaneta, Y1
Inoue, D1
Matsumoto, T1
Harigaya, K1
Fujita, T1
Miles, PD1
Barak, Y1
Evans, RM1
Olefsky, JM1
Umeda, F1
Yagi, N1
Takasu, N1
Higa, S1
Ishikawa, K1
Murakami, K1
Mimura, G1
Jia, DM3
Tabaru, A2
Nakamura, H1
Fukumitsu, KI2
Akiyama, T2
Otsuki, M3
Matsumoto, AM2
Marck, BT2
Gruenewald, DA1
Wolden-Hanson, T2
Naai, MA1

Reviews

1 review available for troglitazone and Aging

ArticleYear
Potential role of thiazolidinediones in older diabetic patients.
    Drugs & aging, 1995, Volume: 7, Issue:5

    Topics: Aged; Aging; Animals; Benzopyrans; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose

1995

Other Studies

9 other studies available for troglitazone and Aging

ArticleYear
Differentiation potential and profile of nuclear receptor expression during expanded culture of human adipose tissue-derived stem cells reveals PPARĪ³ as an important regulator of Oct4 expression.
    Stem cells and development, 2014, Jan-01, Volume: 23, Issue:1

    Topics: Adipose Tissue; Aging; Anilides; Biomarkers; Cell Culture Techniques; Cell Differentiation; Cell Pro

2014
Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.
    The Journal of biological chemistry, 2002, Dec-13, Volume: 277, Issue:50

    Topics: Aging; Animals; Base Sequence; Bone Development; Bone Marrow Cells; Bone Morphogenetic Proteins; Bon

2002
Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding.
    American journal of physiology. Endocrinology and metabolism, 2003, Volume: 284, Issue:3

    Topics: Aging; Animals; Chromans; Dietary Fats; Heterozygote; Insulin Resistance; Metabolism, Inborn Errors;

2003
Effect of troglitazone, a new oral antidiabetic agent, on fructose-induced insulin resistance.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1995, Volume: 27, Issue:10

    Topics: Aging; Animals; Blood Glucose; Body Weight; Chromans; Fructose; Hyperinsulinism; Hypoglycemic Agents

1995
Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes.
    Metabolism: clinical and experimental, 2000, Volume: 49, Issue:9

    Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Body Weight; Cholesterol; Chromans; Diabetes Mellitus

2000
Aging and the neuroendocrine regulation of reproduction and body weight.
    Experimental gerontology, 2000, Volume: 35, Issue:9-10

    Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Body Composition; Body Weight; Chromans; Eating; Ge

2000
Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2001, Volume: 280, Issue:5

    Topics: Aging; Amylases; Animals; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Fibrosis; Homeostasis;

2001
Troglitazone stimulates pancreatic growth in normal rats.
    Pancreas, 2002, Volume: 24, Issue:3

    Topics: Aging; Alanine Transaminase; Amylases; Animals; Aspartate Aminotransferases; Blood Glucose; Body Wei

2002
Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression.
    Experimental gerontology, 2002, Volume: 37, Issue:5

    Topics: Aging; Animals; Body Composition; Chromans; Eating; Fasting; Gene Expression; Hypoglycemic Agents; H

2002