troglitazone has been researched along with Aging in 10 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone, a newly developed oral antidiabetic agent, improves hyperglycemia, and has been reported to improve insulin resistance and to decrease hepatic glucose production in diabetic animals." | 7.69 | Effect of troglitazone, a new oral antidiabetic agent, on fructose-induced insulin resistance. ( Higa, S; Ishikawa, K; Mimura, G; Murakami, K; Takasu, N; Yagi, N, 1995) |
| "Troglitazone treatment did not increase ARC NPY gene expression either after a 72 h fast and re-feeding for 2 weeks (Experiment 1) or immediately after a 72 h fast (Experiment 2)." | 5.31 | Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. ( Marck, BT; Matsumoto, AM; Wolden-Hanson, T, 2002) |
| "To examine the effect of chronic oral administration of troglitazone on the age-related changes of insulin resistance, plasma CCK levels, and pancreatic growth in normal rats." | 3.71 | Troglitazone stimulates pancreatic growth in normal rats. ( Jia, DM; Otsuki, M, 2002) |
| " We found that these rats exhibit reduced food intake and body weight gain associated with decreased hypothalamic neuropeptide Y (NPY) gene expression in the arcuate nucleus (ARC), both during ad-libitum feeding and after a 72-h fast." | 3.70 | Aging and the neuroendocrine regulation of reproduction and body weight. ( Gruenewald, DA; Marck, BT; Matsumoto, AM; Naai, MA; Wolden-Hanson, T, 2000) |
| "Troglitazone, a newly developed oral antidiabetic agent, improves hyperglycemia, and has been reported to improve insulin resistance and to decrease hepatic glucose production in diabetic animals." | 3.69 | Effect of troglitazone, a new oral antidiabetic agent, on fructose-induced insulin resistance. ( Higa, S; Ishikawa, K; Mimura, G; Murakami, K; Takasu, N; Yagi, N, 1995) |
| "Troglitazone has been shown to improve insulin sensitivity and thereby exert hypoglycemic effects in various animal models and humans with insulin resistance and diabetes." | 1.31 | Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes. ( Akiyama, T; Fukumitsu, KI; Jia, DM; Nakamura, H; Otsuki, M; Tabaru, A, 2000) |
| "Troglitazone treatment significantly increased pancreatic wet weight and protein, DNA, and enzyme contents compared with those in the control rats." | 1.31 | Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats. ( Akiyama, T; Fukumitsu, KI; Jia, DM; Otsuki, M; Tabaru, A, 2001) |
| "Troglitazone treatment did not increase ARC NPY gene expression either after a 72 h fast and re-feeding for 2 weeks (Experiment 1) or immediately after a 72 h fast (Experiment 2)." | 1.31 | Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. ( Marck, BT; Matsumoto, AM; Wolden-Hanson, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 7 (70.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dao, LT | 1 |
| Park, EY | 1 |
| Hwang, OK | 1 |
| Cha, JY | 1 |
| Jun, HS | 1 |
| Takeuchi, Y | 1 |
| Watanabe, S | 1 |
| Ishii, G | 1 |
| Takeda, S | 1 |
| Nakayama, K | 1 |
| Fukumoto, S | 1 |
| Kaneta, Y | 1 |
| Inoue, D | 1 |
| Matsumoto, T | 1 |
| Harigaya, K | 1 |
| Fujita, T | 1 |
| Miles, PD | 1 |
| Barak, Y | 1 |
| Evans, RM | 1 |
| Olefsky, JM | 1 |
| Umeda, F | 1 |
| Yagi, N | 1 |
| Takasu, N | 1 |
| Higa, S | 1 |
| Ishikawa, K | 1 |
| Murakami, K | 1 |
| Mimura, G | 1 |
| Jia, DM | 3 |
| Tabaru, A | 2 |
| Nakamura, H | 1 |
| Fukumitsu, KI | 2 |
| Akiyama, T | 2 |
| Otsuki, M | 3 |
| Matsumoto, AM | 2 |
| Marck, BT | 2 |
| Gruenewald, DA | 1 |
| Wolden-Hanson, T | 2 |
| Naai, MA | 1 |
1 review available for troglitazone and Aging
| Article | Year |
|---|---|
Potential role of thiazolidinediones in older diabetic patients.
Topics: Aged; Aging; Animals; Benzopyrans; Chromans; Diabetes Mellitus, Type 2; Double-Blind Method; Glucose | 1995 |
9 other studies available for troglitazone and Aging
| Article | Year |
|---|---|
Differentiation potential and profile of nuclear receptor expression during expanded culture of human adipose tissue-derived stem cells reveals PPARĪ³ as an important regulator of Oct4 expression.
Topics: Adipose Tissue; Aging; Anilides; Biomarkers; Cell Culture Techniques; Cell Differentiation; Cell Pro | 2014 |
Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice.
Topics: Aging; Animals; Base Sequence; Bone Development; Bone Marrow Cells; Bone Morphogenetic Proteins; Bon | 2002 |
Effect of heterozygous PPARgamma deficiency and TZD treatment on insulin resistance associated with age and high-fat feeding.
Topics: Aging; Animals; Chromans; Dietary Fats; Heterozygote; Insulin Resistance; Metabolism, Inborn Errors; | 2003 |
Effect of troglitazone, a new oral antidiabetic agent, on fructose-induced insulin resistance.
Topics: Aging; Animals; Blood Glucose; Body Weight; Chromans; Fructose; Hyperinsulinism; Hypoglycemic Agents | 1995 |
Troglitazone prevents and reverses dyslipidemia, insulin secretory defects, and histologic abnormalities in a rat model of naturally occurring obese diabetes.
Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Body Weight; Cholesterol; Chromans; Diabetes Mellitus | 2000 |
Aging and the neuroendocrine regulation of reproduction and body weight.
Topics: Aging; Animals; Arcuate Nucleus of Hypothalamus; Body Composition; Body Weight; Chromans; Eating; Ge | 2000 |
Troglitazone stimulates pancreatic growth in congenitally CCK-A receptor-deficient OLETF rats.
Topics: Aging; Amylases; Animals; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Fibrosis; Homeostasis; | 2001 |
Troglitazone stimulates pancreatic growth in normal rats.
Topics: Aging; Alanine Transaminase; Amylases; Animals; Aspartate Aminotransferases; Blood Glucose; Body Wei | 2002 |
Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression.
Topics: Aging; Animals; Body Composition; Chromans; Eating; Fasting; Gene Expression; Hypoglycemic Agents; H | 2002 |