troglitazone has been researched along with Adverse Drug Event in 17 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since that review, some new knowledge allows us to better predict that some structural moieties are more likely than others to form drug reactive metabolites that may be involved in causing toxic effects in humans." | 2.41 | Structure toxicity relationships--how useful are they in predicting toxicities of new drugs? ( Nelson, SD, 2001) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Dirven, H | 1 |
| Vist, GE | 1 |
| Bandhakavi, S | 1 |
| Mehta, J | 1 |
| Fitch, SE | 1 |
| Pound, P | 1 |
| Ram, R | 1 |
| Kincaid, B | 1 |
| Leenaars, CHC | 1 |
| Wright, RA | 1 |
| Tsaioun, K | 1 |
| Woodhead, JL | 1 |
| Watkins, PB | 1 |
| Howell, BA | 1 |
| Siler, SQ | 1 |
| Shoda, LKM | 1 |
| Yokoi, T | 1 |
| Ikeda, T | 3 |
| Lee, WM | 1 |
| Smith, DA | 1 |
| Johnson, DE | 2 |
| Park, BK | 1 |
| Rodgers, AD | 1 |
| Wolbert, CJ | 1 |
| Stern, MP | 1 |
| Nelson, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cells of Monocytic Origin as Surrogate Markers for Individual Drug Effects and Hepatotoxicity[NCT02353455] | 300 participants (Anticipated) | Observational | 2013-03-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for troglitazone and Adverse Drug Event
| Article | Year |
|---|---|
Performance of preclinical models in predicting drug-induced liver injury in humans: a systematic review.
Topics: Chemical and Drug Induced Liver Injury; Diabetes Mellitus; Drug-Related Side Effects and Adverse Rea | 2021 |
The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury.
Topics: Animals; Benzazepines; Chemical and Drug Induced Liver Injury; Chromans; Drug-Related Side Effects a | 2017 |
[Idiosyncratic drug toxicity].
Topics: Adaptive Immunity; Animals; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 Enzym | 2012 |
Drug-induced hepatotoxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Chemical and Drug Induced Liv | 2003 |
Computational toxicology: heading toward more relevance in drug discovery and development.
Topics: Animals; Chromans; Computational Biology; Drug Design; Drug-Related Side Effects and Adverse Reactio | 2006 |
[Drug-induced liver injury].
Topics: Acetaminophen; Anesthetics, General; Animals; Benzoquinones; Chemical and Drug Induced Liver Injury; | 2006 |
Structure toxicity relationships--how useful are they in predicting toxicities of new drugs?
Topics: Analgesics; Androgen Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenze | 2001 |
10 other studies available for troglitazone and Adverse Drug Event
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Current topics in drug metabolism and drug toxicity. Preface.
Topics: Chromans; Drug-Related Side Effects and Adverse Reactions; Humans; Inflammation; Pharmaceutical Prep | 2011 |
Editorial overview: safety of drugs can never be absolute.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Chromans; | 2006 |
SNP communications: coalition of toxicology and drug metabolism and pharmacokinetics.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Chromans; Drug-Related Side Effe | 2007 |
Tort law: Desiano and the Second Circuit's repudiation of de jure tort reform.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Diabetes Mellitus, Type 2; Drug Approval; Drug Ind | 2007 |
On the need for outcome trials in preventive pharmacology. Lessons from the recent experience with adverse drug reactions.
Topics: Chromans; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Drug-Related Side Effects and Adverse | 1999 |