troglitazone has been researched along with Adult Premature Aging Syndrome in 2 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Insulin resistance in Werner's syndrome (WS) is probably due to defective signaling distal to the insulin receptor." | 5.30 | Troglitazone ameliorates insulin resistance in patients with Werner's syndrome. ( Akazawa, S; Chikuba, N; Ishibashi, M; Izumino, K; Matsumoto, K; Nagataki, S; Sakamaki, H; Takino, H; Tokuyama, K; Yamaguchi, Y; Yamasaki, H, 1997) |
| "Insulin resistance in Werner's syndrome (WS) is probably due to defective signaling distal to the insulin receptor." | 1.30 | Troglitazone ameliorates insulin resistance in patients with Werner's syndrome. ( Akazawa, S; Chikuba, N; Ishibashi, M; Izumino, K; Matsumoto, K; Nagataki, S; Sakamaki, H; Takino, H; Tokuyama, K; Yamaguchi, Y; Yamasaki, H, 1997) |
| "Werner's syndrome is a rare inheritated disorder characterized by accelerated aging and is often accompanied by diabetes mellitus or impaired glucose tolerance." | 1.29 | Increased insulin responsiveness after CS-045 treatment in diabetes associated with Werner's syndrome. ( Akazawa, S; Kawasaki, E; Matsumoto, K; Okuno, S; Takao, Y; Takino, H; Uotani, S; Yamaguchi, Y; Yamasaki, H; Yano, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takino, H | 2 |
| Okuno, S | 1 |
| Uotani, S | 1 |
| Yano, M | 1 |
| Matsumoto, K | 2 |
| Kawasaki, E | 1 |
| Takao, Y | 1 |
| Yamasaki, H | 2 |
| Yamaguchi, Y | 2 |
| Akazawa, S | 2 |
| Izumino, K | 1 |
| Sakamaki, H | 1 |
| Ishibashi, M | 1 |
| Chikuba, N | 1 |
| Tokuyama, K | 1 |
| Nagataki, S | 1 |
2 other studies available for troglitazone and Adult Premature Aging Syndrome
| Article | Year |
|---|---|
Increased insulin responsiveness after CS-045 treatment in diabetes associated with Werner's syndrome.
Topics: Adult; Blood Glucose; Chromans; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; | 1994 |
Troglitazone ameliorates insulin resistance in patients with Werner's syndrome.
Topics: Adult; Blood Glucose; Chromans; Female; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin | 1997 |