troglitazone has been researched along with Acute Hepatic Failure in 10 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Data from cases of liver failure associated with troglitazone use were abstracted and analyzed." | 7.72 | Troglitazone-induced liver failure: a case study. ( Graham, DJ; Green, L; Nourjah, P; Senior, JR, 2003) |
| "Data from cases of liver failure associated with troglitazone use were abstracted and analyzed." | 3.72 | Troglitazone-induced liver failure: a case study. ( Graham, DJ; Green, L; Nourjah, P; Senior, JR, 2003) |
| " This is further supported by experimental data that demonstrate that troglitazone, alone among the thiazolidinediones, is toxic in hepatocyte cell culture." | 2.42 | Hepatotoxicity of the thiazolidinediones. ( Chandramouli, J; Tolman, KG, 2003) |
| "Troglitazone use was associated with a marked increase in risk of hospitalized acute idiopathic liver injury and ALF." | 1.32 | Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone. ( Drinkard, CR; Graham, DJ; Shatin, D, 2003) |
| "Troglitazone is a thiazolidinedione with insulin-sensitizing activities when administered to humans or animals with type 2 diabetes mellitus." | 1.31 | Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin. ( Chaudhry, MU; Simmons, DL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Graham, DJ | 4 |
| Drinkard, CR | 2 |
| Shatin, D | 2 |
| Green, L | 1 |
| Senior, JR | 1 |
| Nourjah, P | 1 |
| Tolman, KG | 1 |
| Chandramouli, J | 1 |
| Watkins, PB | 1 |
| Lewis, JH | 1 |
| Shimizu, N | 1 |
| Jagannath, S | 1 |
| Rai, R | 1 |
| Chaudhry, MU | 1 |
| Simmons, DL | 1 |
| Tsong, Y | 1 |
| Burgess, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| LabAlert: Enhancing Medication Safety Through Electronic Interventions to Improve Medication Safety[NCT00256386] | 800 participants | Interventional | 2004-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for troglitazone and Acute Hepatic Failure
| Article | Year |
|---|---|
Hepatotoxicity of the thiazolidinediones.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Liver Failure, Acute; | 2003 |
[Proper usage of thiazolidinediones].
Topics: Chromans; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin Resistance; Liver Failure, | 2000 |
8 other studies available for troglitazone and Acute Hepatic Failure
| Article | Year |
|---|---|
Incidence of idiopathic acute liver failure and hospitalized liver injury in patients treated with troglitazone.
Topics: Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Chromans; Female; Hospitalization; | 2003 |
Troglitazone-induced liver failure: a case study.
Topics: Age Distribution; Aged; Chemical and Drug Induced Liver Injury; Chromans; Chronic Disease; Confidenc | 2003 |
Risk of unexplained acute liver failure in diabetes mellitus.
Topics: Chromans; Diabetes Mellitus; Hepatic Encephalopathy; Humans; Hypoglycemic Agents; Liver Failure, Acu | 2003 |
Idiosyncratic liver injury: challenges and approaches.
Topics: Adaptation, Physiological; Chemical and Drug Induced Liver Injury, Chronic; Chromans; Humans; Hypogl | 2005 |
'Hy's law,' the 'Rezulin Rule,' and other predictors of severe drug-induced hepatotoxicity: putting risk-benefit into perspective.
Topics: Alanine Transaminase; Anticoagulants; Azetidines; Benzylamines; Bilirubin; Biomarkers; Chemical and | 2006 |
Rapid-onset subfulminant liver failure associated with troglitazone.
Topics: Chemical and Drug Induced Liver Injury; Chromans; Humans; Hypoglycemic Agents; Liver Failure, Acute; | 2000 |
Case of the month. Hepatic and renal failure in a patient taking troglitazone and metformin.
Topics: Acute Kidney Injury; Chromans; Drug Therapy, Combination; Humans; Hypoglycemic Agents; Liver Failure | 2001 |
Liver enzyme monitoring in patients treated with troglitazone.
Topics: Chromans; Drug Labeling; Humans; Hypoglycemic Agents; Liver; Liver Failure, Acute; Liver Function Te | 2001 |