troglitazone has been researched along with Acute Disease in 5 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Troglitazone treatment of type 2 diabetic patients diminishes sCD40L levels, suggesting a novel antiinflammatory mechanism for limiting diabetes-associated arterial disease." | 2.71 | Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones. ( Bernal, MR; Calle-Pascual, AL; Fernández-Cruz, A; Goldfine, A; Horton, E; Jarolim, P; Libby, P; Nuzzo, R; Schönbeck, U; Varo, JJ; Varo, N; Veves, A; Vicent, D, 2003) |
| "Acute pancreatitis is a severe inflammatory disease of the pancreas." | 1.72 | Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells. ( Ahn, YJ; Kim, H; Lim, JW, 2022) |
| "Acute liver failure was defined as acute liver disease and (1) hepatic encephalopathy, (2) prothrombin time prolongation greater than 3 seconds or international normalized ratio greater than 1." | 1.32 | A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents. ( Ackerson, L; Chan, KA; Everhart, JE; Gurwitz, JH; Hurley, JS; Martinson, B; Moseley, RH; Platt, R; Selby, JV; Terrault, N; Truman, A, 2003) |
| "Troglitazone (Rezulin) is a promising new oral hypoglycemic agent recently approved by the Federal Drug Administration for use in type II diabetes mellitus." | 1.30 | Potential interaction of troglitazone and cyclosporine. ( Bonomini, L; DeFranco, P; Friedman, G; Jacobs, M; Kaplan, B; Lyman, N; Mulgaonkar, SP; Viscuso, R, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahn, YJ | 1 |
| Lim, JW | 1 |
| Kim, H | 1 |
| Saubermann, LJ | 1 |
| Nakajima, A | 1 |
| Wada, K | 1 |
| Zhao, S | 1 |
| Terauchi, Y | 1 |
| Kadowaki, T | 1 |
| Aburatani, H | 1 |
| Matsuhashi, N | 1 |
| Nagai, R | 1 |
| Blumberg, RS | 1 |
| Chan, KA | 1 |
| Truman, A | 1 |
| Gurwitz, JH | 1 |
| Hurley, JS | 1 |
| Martinson, B | 1 |
| Platt, R | 1 |
| Everhart, JE | 1 |
| Moseley, RH | 1 |
| Terrault, N | 1 |
| Ackerson, L | 1 |
| Selby, JV | 1 |
| Varo, N | 1 |
| Vicent, D | 1 |
| Libby, P | 1 |
| Nuzzo, R | 1 |
| Calle-Pascual, AL | 1 |
| Bernal, MR | 1 |
| Fernández-Cruz, A | 1 |
| Veves, A | 1 |
| Jarolim, P | 1 |
| Varo, JJ | 1 |
| Goldfine, A | 1 |
| Horton, E | 1 |
| Schönbeck, U | 1 |
| Kaplan, B | 1 |
| Friedman, G | 1 |
| Jacobs, M | 1 |
| Viscuso, R | 1 |
| Lyman, N | 1 |
| DeFranco, P | 1 |
| Bonomini, L | 1 |
| Mulgaonkar, SP | 1 |
1 trial available for troglitazone and Acute Disease
| Article | Year |
|---|---|
Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones.
Topics: Acute Disease; Adult; Aged; Arteriosclerosis; Body Mass Index; CD40 Ligand; Chromans; Chronic Diseas | 2003 |
4 other studies available for troglitazone and Acute Disease
| Article | Year |
|---|---|
Lutein inhibits IL‑6 expression by inducing PPAR‑γ activation and SOCS3 expression in cerulein‑stimulated pancreatic acinar cells.
Topics: Acinar Cells; Acute Disease; Ceruletide; Humans; Interleukin-6; Lutein; Pancreatitis; PPAR gamma; ST | 2022 |
Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis.
Topics: Acute Disease; Animals; Antibody Formation; Antioxidants; Chromans; Colitis; Cytokines; Disease Mode | 2002 |
A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents.
Topics: Acute Disease; Adult; Aged; Chemical and Drug Induced Liver Injury; Chromans; Cohort Studies; Female | 2003 |
Potential interaction of troglitazone and cyclosporine.
Topics: Acute Disease; Chromans; Cyclosporine; Drug Interactions; Female; Graft Rejection; Humans; Hypoglyce | 1998 |