troglitazone has been researched along with Acidosis in 7 studies
Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.
Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.
Excerpt | Relevance | Reference |
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"We previously showed that troglitazone (TRO) induces a profound cellular acidosis in MCF-7 cells as a result of inhibiting Na(+)/H(+) exchanger (NHE)1-mediated acid extrusion and this was associated with a marked reduction in cellular proliferation." | 7.74 | Role of epidermal growth factor receptor (EGFR)-signaling versus cellular acidosis via Na+/H+ exchanger1(NHE1)-inhibition in troglitazone-induced growth arrest of breast cancer-derived cells MCF-7. ( Friday, E; Oliver, R; Turturro, F; Welbourne, T, 2007) |
"We studied the signal pathway through which troglitazone (TRO) acts in inducing cellular acidosis in LLC-PK1-F+ cells in relation to ammoniagenesis and DNA synthesis." | 7.73 | Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses. ( Friday, E; Lacy, A; Oliver, R; Turturro, F; Welbourne, T, 2005) |
"The purpose of this study was to assess whether troglitazone (TRO) would induce cellular acidosis by inhibiting Na(+)/H(+) exchanger (NHE) 1 in breast carcinoma-derived cell lines and, if so, whether cellular acidosis would be associated with a reduction in proliferation." | 7.72 | Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines. ( Fowler, R; Friday, E; Surie, D; Turturro, F; Welbourne, T, 2004) |
"We previously showed that troglitazone (TRO) induces a profound cellular acidosis in MCF-7 cells as a result of inhibiting Na(+)/H(+) exchanger (NHE)1-mediated acid extrusion and this was associated with a marked reduction in cellular proliferation." | 3.74 | Role of epidermal growth factor receptor (EGFR)-signaling versus cellular acidosis via Na+/H+ exchanger1(NHE1)-inhibition in troglitazone-induced growth arrest of breast cancer-derived cells MCF-7. ( Friday, E; Oliver, R; Turturro, F; Welbourne, T, 2007) |
"We studied the signal pathway through which troglitazone (TRO) acts in inducing cellular acidosis in LLC-PK1-F+ cells in relation to ammoniagenesis and DNA synthesis." | 3.73 | Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses. ( Friday, E; Lacy, A; Oliver, R; Turturro, F; Welbourne, T, 2005) |
"The purpose of this study was to assess whether troglitazone (TRO) would induce cellular acidosis by inhibiting Na(+)/H(+) exchanger (NHE) 1 in breast carcinoma-derived cell lines and, if so, whether cellular acidosis would be associated with a reduction in proliferation." | 3.72 | Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines. ( Fowler, R; Friday, E; Surie, D; Turturro, F; Welbourne, T, 2004) |
"Troglitazone was studied in pH-sensitive LLC-PK1-F+ cells to determine the effect on pHi and glutamine metabolism as well as the role of peroxisome proliferator-activated receptor (PPARgamma)-dependent and PPARgamma-independent signaling pathways." | 1.32 | Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism. ( Fowler, R; Friday, E; Nissim, I; Turturro, F; Welbourne, T, 2004) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 7 (100.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Coates, G | 1 |
Nissim, I | 3 |
Battarbee, H | 1 |
Welbourne, T | 6 |
Friday, E | 4 |
Fowler, R | 2 |
Turturro, F | 4 |
Surie, D | 1 |
Oliver, R | 2 |
Lacy, A | 1 |
Muto, S | 1 |
Miyata, Y | 1 |
Imai, M | 1 |
Asano, Y | 1 |
Routh, R | 1 |
Yudkoff, M | 1 |
7 other studies available for troglitazone and Acidosis
Article | Year |
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Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.
Topics: Acidosis; Alanine Transaminase; Animals; Cell Line; Chromans; Epithelial Cells; Glutamine; Hydrogen- | 2002 |
Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism.
Topics: Acid-Base Equilibrium; Acidosis; Alanine; Alkaloids; Animals; Antineoplastic Agents; Benzhydryl Comp | 2004 |
Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines.
Topics: Acidosis; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Chromans; DNA; Femal | 2004 |
Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Chromans; Enzyme Activation; Hypoglycemic Agents; Kidney T | 2005 |
Role of epidermal growth factor receptor (EGFR)-signaling versus cellular acidosis via Na+/H+ exchanger1(NHE1)-inhibition in troglitazone-induced growth arrest of breast cancer-derived cells MCF-7.
Topics: Acidosis; Breast Neoplasms; Cation Transport Proteins; Cell Line, Tumor; Cell Proliferation; Chroman | 2007 |
Troglitazone stimulates basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules.
Topics: Acidosis; Animals; Bicarbonates; Cell Membrane; Cell Polarity; Chromans; Dose-Response Relationship, | 2001 |
The glutamine/glutamate couplet and cellular function.
Topics: Acidosis; Animals; Cell Physiological Phenomena; Chromans; Cytosol; Glutamic Acid; Glutamine; Thiazo | 2001 |