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troglitazone and Acidosis

troglitazone has been researched along with Acidosis in 7 studies

Troglitazone: A chroman and thiazolidinedione derivative that acts as a PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) agonist. It was formerly used in the treatment of TYPE 2 DIABETES MELLITUS, but has been withdrawn due to hepatotoxicity.

Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.

Research Excerpts

ExcerptRelevanceReference
"We previously showed that troglitazone (TRO) induces a profound cellular acidosis in MCF-7 cells as a result of inhibiting Na(+)/H(+) exchanger (NHE)1-mediated acid extrusion and this was associated with a marked reduction in cellular proliferation."7.74Role of epidermal growth factor receptor (EGFR)-signaling versus cellular acidosis via Na+/H+ exchanger1(NHE1)-inhibition in troglitazone-induced growth arrest of breast cancer-derived cells MCF-7. ( Friday, E; Oliver, R; Turturro, F; Welbourne, T, 2007)
"We studied the signal pathway through which troglitazone (TRO) acts in inducing cellular acidosis in LLC-PK1-F+ cells in relation to ammoniagenesis and DNA synthesis."7.73Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses. ( Friday, E; Lacy, A; Oliver, R; Turturro, F; Welbourne, T, 2005)
"The purpose of this study was to assess whether troglitazone (TRO) would induce cellular acidosis by inhibiting Na(+)/H(+) exchanger (NHE) 1 in breast carcinoma-derived cell lines and, if so, whether cellular acidosis would be associated with a reduction in proliferation."7.72Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines. ( Fowler, R; Friday, E; Surie, D; Turturro, F; Welbourne, T, 2004)
"We previously showed that troglitazone (TRO) induces a profound cellular acidosis in MCF-7 cells as a result of inhibiting Na(+)/H(+) exchanger (NHE)1-mediated acid extrusion and this was associated with a marked reduction in cellular proliferation."3.74Role of epidermal growth factor receptor (EGFR)-signaling versus cellular acidosis via Na+/H+ exchanger1(NHE1)-inhibition in troglitazone-induced growth arrest of breast cancer-derived cells MCF-7. ( Friday, E; Oliver, R; Turturro, F; Welbourne, T, 2007)
"We studied the signal pathway through which troglitazone (TRO) acts in inducing cellular acidosis in LLC-PK1-F+ cells in relation to ammoniagenesis and DNA synthesis."3.73Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses. ( Friday, E; Lacy, A; Oliver, R; Turturro, F; Welbourne, T, 2005)
"The purpose of this study was to assess whether troglitazone (TRO) would induce cellular acidosis by inhibiting Na(+)/H(+) exchanger (NHE) 1 in breast carcinoma-derived cell lines and, if so, whether cellular acidosis would be associated with a reduction in proliferation."3.72Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines. ( Fowler, R; Friday, E; Surie, D; Turturro, F; Welbourne, T, 2004)
"Troglitazone was studied in pH-sensitive LLC-PK1-F+ cells to determine the effect on pHi and glutamine metabolism as well as the role of peroxisome proliferator-activated receptor (PPARgamma)-dependent and PPARgamma-independent signaling pathways."1.32Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism. ( Fowler, R; Friday, E; Nissim, I; Turturro, F; Welbourne, T, 2004)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Coates, G1
Nissim, I3
Battarbee, H1
Welbourne, T6
Friday, E4
Fowler, R2
Turturro, F4
Surie, D1
Oliver, R2
Lacy, A1
Muto, S1
Miyata, Y1
Imai, M1
Asano, Y1
Routh, R1
Yudkoff, M1

Other Studies

7 other studies available for troglitazone and Acidosis

ArticleYear
Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 283, Issue:4

    Topics: Acidosis; Alanine Transaminase; Animals; Cell Line; Chromans; Epithelial Cells; Glutamine; Hydrogen-

2002
Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism.
    American journal of physiology. Renal physiology, 2004, Volume: 286, Issue:1

    Topics: Acid-Base Equilibrium; Acidosis; Alanine; Alkaloids; Animals; Antineoplastic Agents; Benzhydryl Comp

2004
Troglitazone acts on cellular pH and DNA synthesis through a peroxisome proliferator-activated receptor gamma-independent mechanism in breast cancer-derived cell lines.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Oct-15, Volume: 10, Issue:20

    Topics: Acidosis; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Chromans; DNA; Femal

2004
Troglitazone's rapid and sustained activation of ERK1/2 induces cellular acidosis in LLC-PK1-F+ cells: physiological responses.
    American journal of physiology. Renal physiology, 2005, Volume: 288, Issue:6

    Topics: Acid-Base Equilibrium; Acidosis; Animals; Chromans; Enzyme Activation; Hypoglycemic Agents; Kidney T

2005
Role of epidermal growth factor receptor (EGFR)-signaling versus cellular acidosis via Na+/H+ exchanger1(NHE1)-inhibition in troglitazone-induced growth arrest of breast cancer-derived cells MCF-7.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2007, Volume: 20, Issue:6

    Topics: Acidosis; Breast Neoplasms; Cation Transport Proteins; Cell Line, Tumor; Cell Proliferation; Chroman

2007
Troglitazone stimulates basolateral rheogenic Na+/HCO3- cotransport activity in rabbit proximal straight tubules.
    Experimental nephrology, 2001, Volume: 9, Issue:3

    Topics: Acidosis; Animals; Bicarbonates; Cell Membrane; Cell Polarity; Chromans; Dose-Response Relationship,

2001
The glutamine/glutamate couplet and cellular function.
    News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society, 2001, Volume: 16

    Topics: Acidosis; Animals; Cell Physiological Phenomena; Chromans; Cytosol; Glutamic Acid; Glutamine; Thiazo

2001