trk-820 and Neuralgia

trk-820 has been researched along with Neuralgia* in 1 studies

Other Studies

1 other study(ies) available for trk-820 and Neuralgia

Article	Year
Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives. Bioorganic & medicinal chemistry letters, 2017, 08-15, Volume: 27, Issue:16 κ-Opioid receptor agonists with high selectivity over the μ-opioid receptor are attractive targets in the development of drugs for pain and pruritus. We previously reported the synthesis of 10α-hydroxy TRK-820 (1). In this study, we elucidated the biological properties of 1 and optimized its 6-acyl unit by modifying our synthetic route. Among the 10α-hydroxy TRK-820 derivatives prepared, 26 showed the most potent κ-opioid agonist activity (EC Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Mice; Molecular Structure; Morphinans; Neuralgia; Rats; Receptors, Opioid, kappa; Spiro Compounds; Structure-Activity Relationship; Substance P	2017

Article

Year

Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives.

Bioorganic & medicinal chemistry letters, 2017, 08-15, Volume: 27, Issue:16

κ-Opioid receptor agonists with high selectivity over the μ-opioid receptor are attractive targets in the development of drugs for pain and pruritus. We previously reported the synthesis of 10α-hydroxy TRK-820 (1). In this study, we elucidated the biological properties of 1 and optimized its 6-acyl unit by modifying our synthetic route. Among the 10α-hydroxy TRK-820 derivatives prepared, 26 showed the most potent κ-opioid agonist activity (EC

Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Mice; Molecular Structure; Morphinans; Neuralgia; Rats; Receptors, Opioid, kappa; Spiro Compounds; Structure-Activity Relationship; Substance P

2017