trk-820 has been researched along with Neuralgia* in 1 studies
1 other study(ies) available for trk-820 and Neuralgia
Article | Year |
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Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives.
κ-Opioid receptor agonists with high selectivity over the μ-opioid receptor are attractive targets in the development of drugs for pain and pruritus. We previously reported the synthesis of 10α-hydroxy TRK-820 (1). In this study, we elucidated the biological properties of 1 and optimized its 6-acyl unit by modifying our synthetic route. Among the 10α-hydroxy TRK-820 derivatives prepared, 26 showed the most potent κ-opioid agonist activity (EC Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Mice; Molecular Structure; Morphinans; Neuralgia; Rats; Receptors, Opioid, kappa; Spiro Compounds; Structure-Activity Relationship; Substance P | 2017 |