trk-820 and Inflammation

trk-820 has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for trk-820 and Inflammation

ArticleYear
Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation.
    Scientific reports, 2021, 04-21, Volume: 11, Issue:1

    Corneal neovascularization (CNV) causes higher-order aberrations, corneal edema, ocular inflammation, and corneal transplant rejection, thereby decreasing visual acuity. In this study, we investigated the effects of topical administration of the kappa opioid receptor agonist nalfurafine (TRK-820) on CNV. To induce CNV, intrastromal corneal sutures were placed on the corneal stroma of BALB/c mice for 2 weeks. Nalfurafine (0.1 µg/2 μL/eye) was topically administered to the cornea once or twice daily after CNV induction. The CNV score, immune cell infiltration, and mRNA levels of angiogenic and pro-inflammatory factors in neovascularized corneas were evaluated using slit-lamp microscopy, immunohistochemistry, flow cytometry, and polymerase chain reaction. The mRNA expression of the kappa opioid receptor gene Oprk1 was significantly upregulated following CNV induction. Topical administration of nalfurafine twice daily significantly suppressed CNV and lymphangiogenesis, as well as reduced the mRNA levels of angiogenic and pro-inflammatory factors in the neovascularized corneas. Moreover, nalfurafine administration twice daily reduced the numbers of infiltrating leukocytes, neutrophils, macrophages, and interferon-γ-producing CD4

    Topics: Administration, Topical; Animals; Corneal Edema; Corneal Neovascularization; Corneal Stroma; Gene Expression; Inflammation; Macrophages; Male; Mice; Mice, Inbred BALB C; Morphinans; Neutrophils; Receptors, Opioid, kappa; RNA, Messenger; Spiro Compounds

2021