trisialoganglioside-gt1 and Demyelinating-Diseases

We report a patient with sensorimotor demyelinating neuropathy with high-titer IgM antibody against gangliosides GD1a, GT1b and GM3. The patient was a 65-year-old male who was hospitalized with chief complaints of muscular weakness of all limbs and numbness of the hands and feet. Nerve-conduction studies revealed reduced conduction velocities of the motor nerves with increased temporal dispersion and loss of sensory nerve action potentials. Treatment with steroids was ineffective. IgM antibody against GD1a, GT1b and GM3, which are known to be the ligands for myelin-associated glycoprotein (MAG), might have played a role in the demyelination in this patient by inhibiting adhesion between myelin and axonal membrane.

Topics: Aged; Antibodies; Demyelinating Diseases; G(M3) Ganglioside; Gangliosides; Humans; Immunoglobulin M; Male; Movement; Sensation

We report a rare case of Guillain-Barré syndrome (GBS) in a patient with anti-GT1a antibody. A 42-year-old man was admitted with dysphagia, dysarthria and weakness in his neck and both upper limbs. Serial electrophysiological studies suggested that the predominant process was demyelination of the motor nerves. Thin-layer chromatography with immunostaining revealed that his serum IgG reacted strongly with GT1a and weakly with GQ1b. He recovered rapidly with plasmapheresis. These findings suggest that anti-GT1a IgG antibody might play an important role in the pathogenesis of bulbar palsy in GBS.

Topics: Adult; Autoantibodies; Bulbar Palsy, Progressive; Demyelinating Diseases; Gangliosides; Humans; Immunoglobulin G; Male; Polyradiculoneuropathy

Topics: Acute Disease; Aged; Demyelinating Diseases; Female; Gangliosides; Humans; Immunoglobulin G; Nerve Growth Factors; Ophthalmoplegia; Peroneal Nerve; Polyradiculoneuropathy; Tibial Nerve