Page last updated: 2024-09-02

triptolide and Rheumatoid Arthritis

triptolide has been researched along with Rheumatoid Arthritis in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.08)	18.2507
2000's	11 (22.92)	29.6817
2010's	16 (33.33)	24.3611
2020's	20 (41.67)	2.80

Authors

Authors	Studies
Cao, X; Deng, X; Huang, D; Peng, W; Tu, H; Wang, R; Wang, X; Wu, M; Zhang, Z; Zhou, X; Zhu, H; Zhu, L	1
Bi, J; Chen, R; Chen, Z; Kong, W; Li, H; Liu, H; Lu, S; Ren, S; Wang, X; Zhu, C	1
Geng, HX; Guo, RB; Kong, L; Li, XT; Liu, Y; Wang, YJ; Wu, YN; Yan, DK; Yu, YJ; Zhang, XY	1
Guo, JC; Liu, J; Sun, YQ; Wan, L; Wang, J; Wang, X; Wen, JT; Xin, L	1
Di, Y; Jiang, B; Wang, X; Xu, A; Yang, R; Zhang, M; Zhou, L; Zhou, Z	1
Jiang, M; Li, M; Wang, G; Wang, Z; Wu, X; Yan, Y; Zeng, H; Zhang, Z	1
Huang, L; Li, M; Ma, G; Ma, Z; Rao, Q; Wu, H; Zhang, C; Zhang, Y	1
Chen, J; Chen, Z; Chu, C; Feng, W; Gong, Z; Li, N; Lin, C; Xu, Q	1
Feng Shi, J; Han Wu, Y; Jiao Zhang, M; Le Gao, H; Mei Zhong, X; Ming Zhang, J; Peng Wang, S; Qu, Y; Xin Li, J	1
Cai, BL; Huang, F; Lin, N; Mao, X; Su, XH; Wang, JR; Wang, KX; Wu, AG; Zhang, YG	1
Ding, Y; Niu, X; Tang, Q; Wang, L	1
Huang, C; Li, F; Liu, J; Wan, L; Wang, K; Zhu, Z	1
Deng, AP; Fu, TX; Qiu, Q; Xie, XY; Zeng, HL	1
He, J; Huang, X; Jiang, Z; Shen, Q; Shu, T; Wang, J; Xu, D; Yuan, Z; Zhang, L	1
Dai, E; Du, H; Song, X; Wang, L; Zhang, Y	1
Dai, E; Song, X; Zhang, Y	1
Han, H; Hou, T; Jin, J; Liang, Q; Liu, Y; Wang, C; Wang, Y; Xu, H; Yang, G; Yang, Y; Zhang, L; Zhang, W; Zhao, Y	1
Che, K; Liu, Y; Wang, L	1
Liu, J; Wang, J; Wang, X; Wen, J	1
Piao, X; Xue, L; Zhou, J	1
Ao, M; Su, Z; Sun, H; Zhao, C	1
Fan, D; Guo, Q; He, X; Lu, A; Lu, C; Shen, J; Zhang, G; Zheng, K	1
Ji, X; Liu, Z; Wang, S; Wang, X; Yao, Z; Zuo, S	1
Huang, G; Lu, Q; Luo, G; Sheng, H; Xu, A; Yu, R; Yuan, K; Zhang, S; Zhu, M; Zhu, Q	1
Ji, X; Liu, J; Liu, Z; Wang, J; Wang, S; Wang, X; Wang, Y	1
Gu, Y; Liu, J; Tang, X; Yang, D; Yang, M	1
Wang, B; Wang, Y; Yang, X	1
Jiang, J; Liu, J; Xie, C; Yuan, G; Zhao, Z	1
Gui, SY; Jiang, XJ; Shan, QQ; Shu, ZX; Wang, FY	1
Guo, W; Kong, X; Li, X; Lin, N; Liu, C; Su, X; Sun, Y; Wan, H; Zhang, Y	1
Huang, X; Liu, R; Peng, A; Wang, X; Zhuang, J	1
Peng, AP; Wang, XY; Zhuang, JH	1
Bian, Y; Fan, D; Guo, Q; He, X; Liu, B; Lu, A; Lu, C; Xu, X; Zhang, G; Zhao, Y; Zheng, K	1
Huang, M; Liang, L; Qiu, Q; Shi, M; Xiao, Y; Xu, H; Yang, X; Yang, Y; Ye, Y	1
Cheng, LF; Feng, L; Leng, JH; Lu, Y; Wang, WJ; Yao, HP	1
Chen, ZK; Lu, HS; Wang, N	1
Mao, XD; Pei, ZY; Sun, SJ; Zhang, LH	1
Guan, Z; Houshan, LV; Jiang, J; Wang, N	1
Bręborowicz, D; Bylka, W; Frankiewicz, D; Grzegorzewska, AE; Matławska, I	1
Shao, CS; Shao, XT; Sun, WJ; Yao, HP; Zhang, LH	1
Aoki, H; Beppu, M; Kawai, S; Kitasato, H; Kusunoki, N; Yamazaki, R	1
Feng, L; Shao, XT; Sun, WJ; Yao, HP; Zhang, LH	1
Altmeyer, P; Bader, A; Brockmeyer, NH; Höxtermann, S; Li, D; Wu, N; Yao, H; Zhou, J	1
Hu, Y; Lai, X; Tu, S; Weichen, Z; Zeng, K; Zhang, M	1
He, YT; Yu, JP; Zha, QL	1
Lin, N; Liu, CF	1
Bai, CJ; Chen, YY; Chen, ZK; Guan, ZP; Jiang, J; Lu, HS; Ruan, GR; Sun, TZ; Wang, N	1
Li, R; Song, Y; Su, D	1

Reviews

4 review(s) available for triptolide and Rheumatoid Arthritis

Article	Year
Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis (Review). Molecular medicine reports, 2020, Volume: 21, Issue:6 Topics: Arthritis, Rheumatoid; Chemokines; Cyclooxygenase 2; Diterpenes; Epoxy Compounds; Humans; NF-kappa B; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Toll-Like Receptor 4; Tripterygium; Triterpenes	2020
The Effect of Triptolide in Rheumatoid Arthritis: From Basic Research towards Clinical Translation. International journal of molecular sciences, 2018, Jan-26, Volume: 19, Issue:2 Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Diterpenes; Drug Evaluation, Preclinical; Epoxy Compounds; Humans; Phenanthrenes	2018
The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide's Toxicity. Current stem cell research & therapy, 2020, Volume: 15, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arthritis, Rheumatoid; Autophagy; Cardiovascular Diseases; Diterpenes; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Neoplasms; Osteoporosis; Phenanthrenes; Plant Extracts; Signal Transduction; Tripterygium	2020
[Progress in research on mechanisms of anti-rheumatoid arthritis of triptolide]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:19 Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cytokines; Dinoprostone; Diterpenes; Epoxy Compounds; Humans; Immunosuppressive Agents; Neovascularization, Pathologic; NF-kappa B; Phenanthrenes; Plants, Medicinal; T-Lymphocytes; Tripterygium	2006

Trials

1 trial(s) available for triptolide and Rheumatoid Arthritis

Article	Year
[Correlations between diagnostic information and therapeutic efficacy in rheumatoid arthritis analyzed with decision tree model]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2006, Volume: 26, Issue:10 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Decision Trees; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Phenanthrenes; Phytotherapy; Treatment Outcome	2006

Article

Year

[Correlations between diagnostic information and therapeutic efficacy in rheumatoid arthritis analyzed with decision tree model].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2006, Volume: 26, Issue:10

Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Decision Trees; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Male; Medicine, Chinese Traditional; Middle Aged; Phenanthrenes; Phytotherapy; Treatment Outcome

2006

Other Studies

43 other study(ies) available for triptolide and Rheumatoid Arthritis

Article	Year
Targeted therapy of rheumatoid arthritis via macrophage repolarization. Drug delivery, 2021, Volume: 28, Issue:1 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Cytokines; Diterpenes; Drug Carriers; Drug Liberation; Epoxy Compounds; Folic Acid; Inflammation Mediators; Lipopolysaccharides; Liposomes; Macrophages; Male; Mice; Phenanthrenes; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells	2021
Acupoint nanocomposite hydrogel for simulation of acupuncture and targeted delivery of triptolide against rheumatoid arthritis. Journal of nanobiotechnology, 2021, Dec-07, Volume: 19, Issue:1 Topics: Acupuncture Points; Acupuncture Therapy; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Behavior, Animal; Delayed-Action Preparations; Diterpenes; Drug Delivery Systems; Epoxy Compounds; Humans; Male; Nanogels; Nanomedicine; Phenanthrenes; Rats; Rats, Sprague-Dawley	2021
Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy. Biomaterials science, 2022, Jan-18, Volume: 10, Issue:2 Topics: Arthritis, Rheumatoid; Diterpenes; Epoxy Compounds; Folic Acid; Humans; Liposomes; Macrophages; Phenanthrenes	2022
Triptolide inhibits cell growth and inflammatory response of fibroblast-like synoviocytes by modulating hsa-circ-0003353/microRNA-31-5p/CDK1 axis in rheumatoid arthritis. International immunopharmacology, 2022, Volume: 106 Topics: Animals; Arthritis, Rheumatoid; CDC2 Protein Kinase; Cell Cycle; Cell Proliferation; Cells, Cultured; Diterpenes; Epoxy Compounds; Fibroblasts; Humans; MicroRNAs; Molecular Docking Simulation; Phenanthrenes; RNA, Circular; Synoviocytes	2022
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment. Journal of drug targeting, 2022, Volume: 30, Issue:9 Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cytokines; Dextrans; Diterpenes; Epoxy Compounds; Folic Acid; Humans; Immunosuppressive Agents; Interleukin-6; Macrophages; Micelles; Nucleotidyltransferases; Phenanthrenes; Tumor Necrosis Factor-alpha	2022
Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation. Drug delivery, 2022, Volume: 29, Issue:1 Topics: Animals; Arthritis, Rheumatoid; Ascorbic Acid; Diterpenes; Epoxy Compounds; Mice; Micelles; Palmitates; Phenanthrenes; Water	2022
Targeted delivery of triptolide by dendritic cell-derived exosomes for colitis and rheumatoid arthritis therapy in murine models. British journal of pharmacology, 2023, Volume: 180, Issue:3 Topics: Animals; Arthritis, Rheumatoid; Colitis; Dendritic Cells; Disease Models, Animal; Exosomes; Mice	2023
Triptolide improves chondrocyte proliferation and secretion via down-regulation of miR-221 in synovial cell exosomes. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 107 Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Chondrocytes; Diterpenes; Down-Regulation; Eosine Yellowish-(YS); Epoxy Compounds; Exosomes; Fibroblasts; Hematoxylin; MicroRNAs; Myeloid Differentiation Factor 88; Phenanthrenes; Rats; Synovial Membrane; Toll-Like Receptor 4	2022
pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide. International journal of pharmaceutics, 2023, Feb-05, Volume: 632 Topics: Animals; Arthritis, Rheumatoid; Hydrogen-Ion Concentration; Inflammation; Macrophages; Nanoparticles; Polyelectrolytes; Polymers; Rats	2023
[In vitro "benefit-risk" evaluation and network regulation mechanism of Colquhounia Root Tablets and its key material basis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:23 Topics: Animals; Arthritis, Rheumatoid; Cytokines; Diabetic Nephropathies; Drugs, Chinese Herbal; Glomerulonephritis, Membranous; Humans; Mice; Molecular Docking Simulation; Tablets	2022
Preparation, Properties and Therapeutic Effect of a TPL Nanoparticle Thermosensitive Gel for Intra-Articular Injection. Molecules (Basel, Switzerland), 2023, Jun-09, Volume: 28, Issue:12 Topics: Animals; Arthritis, Rheumatoid; Injections, Intra-Articular; Joints; Nanoparticles; Rats	2023
A novel pharmaceutical preparation of Tripterygium wilfordii Hook. f. regulates macrophage polarization to alleviate inflammation in rheumatoid arthritis. The Journal of pharmacy and pharmacology, 2023, Nov-23, Volume: 75, Issue:11 Topics: Animals; Arthritis, Rheumatoid; Inflammation; Interleukin-10; Macrophages; Phosphatidylinositol 3-Kinases; Plant Extracts; Rats; Tripterygium; Tumor Necrosis Factor-alpha	2023
Development and optimization of sustained release triptolide microspheres. PloS one, 2023, Volume: 18, Issue:10 Topics: Arthritis, Rheumatoid; Delayed-Action Preparations; Humans; Microspheres; Particle Size	2023
Key role of organic cation transporter 2 for the nephrotoxicity effect of triptolide in rheumatoid arthritis. International immunopharmacology, 2019, Volume: 77 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Line; Cytokines; Diterpenes; Epoxy Compounds; Female; HEK293 Cells; Humans; Kidney; Medicine, Chinese Traditional; Organic Cation Transporter 2; Phenanthrenes; Rats; Rats, Wistar; Renal Insufficiency; Tripterygium; Up-Regulation	2019
Prediction of triptolide targets in rheumatoid arthritis using network pharmacology and molecular docking. International immunopharmacology, 2020, Volume: 80 Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Binding Sites; Computational Biology; Diterpenes; Drug Development; Epoxy Compounds; Feasibility Studies; Humans; Molecular Docking Simulation; Phenanthrenes; Protein Interaction Maps; Signal Transduction	2020
Construction of a pH-responsive, ultralow-dose triptolide nanomedicine for safe rheumatoid arthritis therapy. Acta biomaterialia, 2021, Volume: 121 Topics: Animals; Arthritis, Rheumatoid; Diterpenes; Epoxy Compounds; Hydrogen-Ion Concentration; Mice; Nanomedicine; Phenanthrenes	2021
Pharmacokinetics, distribution and efficacy of triptolide PLGA microspheres after intra-articular injection in a rat rheumatoid arthritis model. Xenobiotica; the fate of foreign compounds in biological systems, 2021, Volume: 51, Issue:6 Topics: Animals; Arthritis, Rheumatoid; Chromatography, Liquid; Diterpenes; Epoxy Compounds; Injections, Intra-Articular; Microspheres; Phenanthrenes; Rats; Tandem Mass Spectrometry	2021
Triptolide promotes the apoptosis and attenuates the inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by down-regulating lncRNA ENST00000619282. Phytotherapy research : PTR, 2021, Volume: 35, Issue:8 Topics: Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Diterpenes; Epoxy Compounds; Fibroblasts; Humans; Inflammation; Leukocytes, Mononuclear; Phenanthrenes; RNA, Long Noncoding; Synoviocytes	2021
Triptolide decreases rheumatoid arthritis fibroblast-like synoviocyte proliferation, invasion, inflammation and presents a therapeutic effect in collagen-induced arthritis rats via inactivating lncRNA RP11-83J16.1 mediated URI1 and β-catenin signaling. International immunopharmacology, 2021, Volume: 99 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; beta Catenin; Cell Movement; Cell Proliferation; Cells, Cultured; Diterpenes; Epoxy Compounds; Fibroblasts; Humans; Male; Phenanthrenes; Primary Cell Culture; Rats; Repressor Proteins; RNA, Long Noncoding; Signal Transduction; Synovial Membrane; Synoviocytes	2021
Atomic Force Microscopy Study of the Anti-inflammatory Effects of Triptolide on Rheumatoid Arthritis Fibroblast-like Synoviocytes. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 2017, Volume: 23, Issue:5 Topics: Anti-Inflammatory Agents; Apoptosis; Arthritis, Rheumatoid; Cell Line; Cell Membrane; Cell Proliferation; Diterpenes; Epoxy Compounds; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Microscopy, Atomic Force; Phenanthrenes; Synoviocytes; Tumor Necrosis Factor-alpha	2017
Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106 Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Biomarkers; Bone Resorption; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Inflammation Mediators; Joints; Lymphocytes; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Osteoclasts; Phenanthrenes; Risk Assessment; Time Factors; Tumor Necrosis Factor-alpha	2018
Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis. Molecular immunology, 2018, Volume: 101 Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Autophagy; Chronic Disease; Cytokines; Diterpenes; Epoxy Compounds; Extracellular Traps; Inflammation; Leukocyte Elastase; Lipopolysaccharides; Male; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Peroxidase; Phenanthrenes	2018
The triptolide-induced apoptosis of osteoclast precursor by degradation of cIAP2 and treatment of rheumatoid arthritis of TNF-transgenic mice. Phytotherapy research : PTR, 2019, Volume: 33, Issue:2 Topics: Adult Stem Cells; Animals; Apoptosis; Arthritis, Rheumatoid; Baculoviral IAP Repeat-Containing 3 Protein; Diterpenes; Epoxy Compounds; HEK293 Cells; Humans; Mice; Mice, Transgenic; Osteoclasts; Phenanthrenes; Proteolysis; Tumor Necrosis Factor-alpha	2019
Transdermal drug delivery of triptolide-loaded nanostructured lipid carriers: Preparation, pharmacokinetic, and evaluation for rheumatoid arthritis. International journal of pharmaceutics, 2019, Jan-10, Volume: 554 Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Delayed-Action Preparations; Disease Models, Animal; Diterpenes; Drug Carriers; Drug Delivery Systems; Drug Liberation; Edema; Epoxy Compounds; Immunosuppressive Agents; Lipids; Male; Microdialysis; Nanostructures; Particle Size; Phenanthrenes; Rats; Rats, Sprague-Dawley; Skin Absorption	2019
Triptolide suppresses human synoviocyte MH7A cells mobility and maintains redox balance by inhibiting autophagy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 115 Topics: Anti-Inflammatory Agents; Antioxidants; Arthritis, Rheumatoid; Autophagy; Cell Culture Techniques; Cell Line; Cell Movement; Cell Proliferation; Diterpenes; Epoxy Compounds; Humans; Oxidation-Reduction; Oxidative Stress; Phenanthrenes; Synoviocytes	2019
Cubic and hexagonal liquid crystals as drug carriers for the transdermal delivery of triptolide. Drug delivery, 2019, Volume: 26, Issue:1 Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Line; Diterpenes; Drug Carriers; Epidermal Cells; Epoxy Compounds; Humans; Interleukin-1beta; Liquid Crystals; Phenanthrenes; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Surface Properties; Tumor Necrosis Factor-alpha	2019
Anti-angiogenic effect of triptolide in rheumatoid arthritis by targeting angiogenic cascade. PloS one, 2013, Volume: 8, Issue:10 Topics: Angiogenesis Modulating Agents; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Adhesion; Cell Movement; Cells, Cultured; Collagen; Diterpenes; Drug Combinations; Epoxy Compounds; Human Umbilical Vein Endothelial Cells; Humans; Laminin; Male; Mitogen-Activated Protein Kinases; Neovascularization, Pathologic; Phenanthrenes; Proteoglycans; Rats; Synovial Membrane; Vascular Endothelial Growth Factor A	2013
[Triptolide inhibits the inflammatory response of monocytes from rheumatoid arthritis patients by regulating miR-155]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2014, Volume: 30, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Diterpenes; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Gene Expression Regulation; Humans; Inositol Polyphosphate 5-Phosphatases; Interleukin-6; Lipopolysaccharides; MicroRNAs; Monocytes; Phenanthrenes; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Reverse Transcriptase Polymerase Chain Reaction; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins; Tripterygium; Tumor Necrosis Factor-alpha	2014
[Triptolide inhibites Th17 cell differentiation via regulating cyclooxygenase-2/ prostaglandin E2 axis in synovial fibroblasts from rheumatoid arthritis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014, Volume: 39, Issue:3 Topics: Arthritis, Rheumatoid; Cell Differentiation; Cell Line; Cyclooxygenase 2; Dinoprostone; Diterpenes; Epoxy Compounds; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Middle Aged; Phenanthrenes; Synovial Fluid; Th17 Cells	2014
Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis. International journal of molecular sciences, 2016, Apr-02, Volume: 17, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Arthritis, Rheumatoid; Cell Line, Tumor; Cytokines; Diterpenes; Epoxy Compounds; Humans; Male; Membrane Glycoproteins; Phenanthrenes; Rats, Sprague-Dawley; Receptors, Immunologic; Signal Transduction; Triggering Receptor Expressed on Myeloid Cells-1; Tripterygium	2016
Triptolide inhibits the migration and invasion of rheumatoid fibroblast-like synoviocytes by blocking the activation of the JNK MAPK pathway. International immunopharmacology, 2016, Volume: 41 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Movement; Cells, Cultured; Diterpenes; Epoxy Compounds; Female; Humans; Joints; MAP Kinase Signaling System; Mice, Inbred NOD; Mice, SCID; Phenanthrenes; Phosphorylation; Synoviocytes; Tumor Necrosis Factor-alpha	2016
Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008, Volume: 57, Issue:6 Topics: Animals; Arthritis, Rheumatoid; Cells, Cultured; Diterpenes; Epoxy Compounds; Fibroblasts; Humans; Immunosuppressive Agents; Interleukin-18; Phenanthrenes; Receptors, Interleukin-18; Synovial Membrane; Tetradecanoylphorbol Acetate; Transcription Factor RelA	2008
[Overexpression of programmed cell death 5 factor enhances triptolides-induced fibroblast-like synoviocytes apoptosis in rheumatoid arthritis]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2008, Dec-18, Volume: 40, Issue:6 Topics: Adenoviridae; Apoptosis; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Cells, Cultured; Diterpenes; Epoxy Compounds; Fibroblasts; Humans; Neoplasm Proteins; Phenanthrenes; Synovial Membrane; Transfection	2008
[Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2009, Volume: 25, Issue:7 Topics: Arthritis, Rheumatoid; Diterpenes; Epoxy Compounds; Fibroblasts; Humans; Immunosuppressive Agents; Interleukin-18; NF-kappa B; Phenanthrenes; Receptors, Interleukin-18; Synovial Membrane	2009
Programmed cell death 5 factor enhances triptolide-induced fibroblast-like synoviocyte apoptosis of rheumatoid arthritis. Artificial cells, blood substitutes, and immobilization biotechnology, 2010, Volume: 38, Issue:1 Topics: Adenoviridae; Apoptosis; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Cell Separation; Cells, Cultured; Cloning, Molecular; Diterpenes; Epoxy Compounds; Fibroblasts; Flow Cytometry; Genetic Vectors; Humans; Neoplasm Proteins; Phenanthrenes; Synovial Membrane; Transfection	2010
Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis. Medical science monitor : international medical journal of experimental and clinical research, 2012, Volume: 18, Issue:8 Topics: Adult; Aged; Arthritis, Rheumatoid; Diterpenes; Edema; Epoxy Compounds; Female; Humans; Immunosuppressive Agents; Leg; Middle Aged; Phenanthrenes; Powders; Sarcoma, Kaposi; Skin Neoplasms	2012
[Enhancement by FK506 of triptolide-induced inhibition of expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts]. Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica, 2003, Volume: 35, Issue:3 Topics: Arthritis, Rheumatoid; Blotting, Western; Cell Division; Cells, Cultured; Cyclooxygenase 2; Dinoprost; Diterpenes; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Immunosuppressive Agents; Isoenzymes; Membrane Proteins; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenanthrenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; Tacrolimus; Tumor Necrosis Factor-alpha	2003
Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts. BMC pharmacology, 2004, Feb-17, Volume: 4 Topics: Apoptosis; Arthritis, Rheumatoid; Caspases; Cell Division; Cell Survival; Cells, Cultured; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Fibroblasts; Humans; Phenanthrenes; Synovial Membrane; Tripterygium	2004
[Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:2 Topics: Arthritis, Rheumatoid; Cyclooxygenase 2; Diterpenes; Epoxy Compounds; Fibroblasts; Gene Expression Regulation; Humans; Isoenzymes; Membrane Proteins; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenanthrenes; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Synovial Membrane; Tumor Necrosis Factor-alpha	2004
FK506 enhances triptolide-induced down-regulation of cyclooxygenase-2, inducible nitric oxide synthase as well as their products PGE2 and NO in TNF-alpha-stimulated synovial fibroblasts from rheumatoid arthritic patients. European journal of medical research, 2005, Mar-29, Volume: 10, Issue:3 Topics: Arthritis, Rheumatoid; Base Sequence; Cell Line; Cyclooxygenase 2; Dinoprostone; Diterpenes; DNA Primers; Down-Regulation; Drug Synergism; Epoxy Compounds; Fibroblasts; Humans; Immunosuppressive Agents; Membrane Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenanthrenes; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane; Tacrolimus; Tumor Necrosis Factor-alpha	2005
Effects of triptolide on the expression and activity of NF-kappaB in synovium of collagen-induced arthritis rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2005, Volume: 25, Issue:5 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Cattle; Diterpenes; Epoxy Compounds; Interleukin-6; Male; NF-kappa B; Phenanthrenes; Random Allocation; Rats; Rats, Wistar; Synovial Membrane; Tumor Necrosis Factor-alpha	2005
Involvement of PDCD5 in the regulation of apoptosis in fibroblast-like synoviocytes of rheumatoid arthritis. Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Apoptosis Regulatory Proteins; Arthritis, Rheumatoid; Caspase 3; Cells, Cultured; Diterpenes; Epoxy Compounds; Fibroblasts; Gene Expression Regulation; Humans; Neoplasm Proteins; Phenanthrenes; Synovial Membrane; Tissue Distribution; Transfection	2007
[Comparative clinical study of rheumatoid arthritis treated by triptolide and an ethyl acetate extract of Tripterygium wilfordii]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine, 1990, Volume: 10, Issue:3 Topics: Adolescent; Adult; Arthritis, Rheumatoid; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Male; Middle Aged; Phenanthrenes; Tripterygium	1990