Page last updated: 2024-09-02

triptolide and Pancreatic Neoplasms

triptolide has been researched along with Pancreatic Neoplasms in 47 studies

Research

Studies (47)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (12.77)	29.6817
2010's	34 (72.34)	24.3611
2020's	7 (14.89)	2.80

Authors

Authors	Studies
Bao, S; Chen, R; Kou, L; Lin, G; Lin, Y; Lou, D; Lou, Z; Luo, Q; Shangguan, H; Zhang, H	1
Kong, W; Liu, H; Liu, Z; Qian, F; Sun, M; Wang, R; Yuan, F	1
Li, S; Mu, L; Wang, S; Wu, P; Yang, R; Zhang, Y	1
Chen, H; Chen, J; Chen, Z; Kuang, Y; Liu, M; Tai, Z; Wang, X; Wei, R; Wu, X; Yang, J; Zhu, Q	1
Chen, J; Chen, L; Chen, Y; Feng, J; Gao, X; Gong, J; Huang, Y; Liu, S; Liu, Y; Lu, H; Song, Q; Wang, J; Xu, M; Zhou, S	1
Cao, D; He, Q; Lang, R; Li, L; Liu, Z; Lyu, S; Ren, Z; Wang, H; Wang, Z; Zhai, J; Zhao, X	1
Du, F; Hu, Y; Huang, Y; Ji, H; Kaboli, PJ; Li, M; Wang, S; Wu, M; Wu, X; Wu, Z; Xiao, Z; Zhao, Y; Zou, T	1
Ding, B; Prabhu, S; Thakkar, A; Wahid, MA; Wang, J; Wang, Z; Xie, C	1
Kang, WK; Kim, K; Kim, ST; Kim, SY; Lee, J; Lim, HY; Park, JO; Park, SH; Park, YS	1
Chen, Z; Feng, J; Liang, L; Lu, W; Pang, X; Rao, M; Sun, Z; Wang, M	1
Gao, J; Hu, Z; Kong, C; Kong, W; Li, Y; Liu, C; Liu, H; Liu, Z; Pang, H; Qian, F; Wang, Z; Ye, J; Zhang, L	1
Borazanci, E; Han, H; Noel, P; Saluja, AK; Velagapudi, M; Von Hoff, DD	1
Bie, P; Chen, Z; Dai, H; Jiang, Y; Luo, Y	1
Banerjee, S; MacKenzie, TN; Mujumdar, N; Saluja, AK; Sangwan, V; Sarver, A; Subramanian, S; Vickers, S	1
Jin, J; Ma, JX; Sun, YL; Wang, YQ; Wu, HY; Yu, XF	1
Banerjee, S; Chen, Z; Dudeja, V; Li, X; Mackenzie, T; Saluja, AK; Sangwan, V; Vickers, SM; Wang, H	1
Banerjee, S; Chugh, R; Dudeja, V; McGinn, O; Saluja, AK; Sangwan, V; Vickers, SM	1
Cui, YF; Liu, Y	1
Aleksandrowicz, E; Bauer, N; Gladkich, J; Herr, I; Labsch, S; Liu, L; Mattern, J; Nwaeburu, C; Salnikov, AV; Schemmer, P; Werner, J	1
Banerjee, S; Chen, Z; Chugh, R; Dudeja, V; Saluja, AK; Sangwan, V; Vickers, SM	1
Banerjee, S; Chen, Z; Chugh, R; Dudeja, V; Mujumdar, N; Saluja, AK; Sangwan, V; Vickers, SM; Yamamoto, M	1
Aleksandrowicz, E; Bauer, N; Herr, I; Liu, L	1
Chen, XG; Ji, M; Jin, J; Lai, FF; Li, Y; Ni, L; Niu, F; Wang, C; Yang, HZ; Zhang, DM	1
Li, K; Li, X; Mao, Y; Shi, T; Wang, S; Yao, H; Yao, J	1
Banerjee, S; Chen, Z; Chugh, R; Dudeja, V; Jensen, KM; Saluja, AK; Sangwan, V; Vickers, SM	1
Ding, X; Jiang, B; Zhao, Q; Zhou, G; Zhou, X	1
Banerjee, S; Saluja, A	1
Banerjee, S; Dudeja, V; McGinn, O; Modi, S; Ramakrishnan, S; Saluja, AK; Zhao, X	1
Arora, N; Banerjee, S; Dudeja, V; Giri, B; Kir, D; Majumder, K; Modi, S; Saluja, AK	1
Banerjee, S; Dudeja, V; McGinn, O; Nomura, A; Saluja, AK; Sangwan, V	1
Cong, M; Li, H; Liu, B; Lu, A; Wang, C; Xu, W; Xu, X; Yin, J; Zhuang, B	1
Andrianov, G; Astsaturov, I; Banina, E; Beglyarova, N; Behrens, D; Bobrov, E; Gabitova, L; Golemis, EA; Hoffman, JP; Jablonski, SA; Khazak, V; Lysenko, E; Mukhamadeeva, R; Paz, K; Pressman, M; Restifo, D; Serebriiskii, IG; Skobeleva, N; Weiner, LM; Zhou, Y	1
Borja-Cacho, D; Chugh, R; Dawra, RK; Dudeja, V; Mujumdar, N; Phillips, P; Saluja, AK; Vickers, SM	1
Kapoor, S	1
Borja-Cacho, D; Chugh, RK; Clawson, KA; Dawra, RK; Dudeja, V; Mujumdar, NR; Saluja, AK; Vickers, SM; Yokoyama, Y	1
Antonoff, MB; Borja-Cacho, D; Chugh, R; Dawra, R; Dudeja, V; Mackenzie, TN; Mujumdar, N; Saluja, AK; Sangwan, V; Vickers, SM	1
Mujumdar, N; Saluja, AK	1
Li, FQ; Wang, W; Xie, XY; Yang, SW; Zhu, WP	1
Ding, X; Qiang, H; Qing, J; Zhang, H; Zhou, G; Zhou, X	1
Hong, B; Li, X; Lv, G; Sun, W; Wang, W; Zhang, L; Zhang, M	1
Hu, H; Le, L; Li, J; Li, S; Qiu, P; Su, X; Wu, S; Yan, G; Zhu, W	1
Hingorani, SR; Potter, JD	1
Banerjee, S; Blazar, BR; Chugh, R; Dawra, RK; Dudeja, V; Georg, GI; Patil, SP; Saluja, AK; Sangwan, V; Schumacher, RJ; Vickers, SM	1
Liu, Y; Matta, R; Nelin, LD; Pei, D; Shen, G; Wang, X	1
Ding, I; Fenton, BM; Keng, P; Li, X; Lin, L; Okunieff, P; Paoni, SF; Su, Y; Wang, C; Wang, W; Xiao, Z; Yang, S; Zhang, L	1
Borja-Cacho, D; Dawra, RK; Dudeja, V; Grizzle, WE; McCarroll, JA; Phillips, PA; Saluja, AK; Vickers, SM	1
Cheng, JP; Ding, XL; Huang, JF; Wei, Q; Wu, SB; Zhang, H; Zhou, GX	1

Reviews

2 review(s) available for triptolide and Pancreatic Neoplasms

Article	Year
Triptolide and Its Derivatives as Cancer Therapies. Trends in pharmacological sciences, 2019, Volume: 40, Issue:5 Topics: Animals; Antineoplastic Agents; Diterpenes; Epoxy Compounds; Humans; Immunosuppressive Agents; Pancreatic Neoplasms; Phenanthrenes	2019
Minnelide, a novel drug for pancreatic and liver cancer. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2015, Volume: 15, Issue:4 Suppl Topics: Animals; Antineoplastic Agents, Alkylating; Diterpenes; Epoxy Compounds; Humans; Liver Neoplasms; Organophosphates; Pancreatic Neoplasms; Phenanthrenes; Prodrugs	2015

Other Studies

45 other study(ies) available for triptolide and Pancreatic Neoplasms

Article	Year
ATB Bioorganic & medicinal chemistry letters, 2021, 02-01, Volume: 33 Topics: Amino Acid Transport Systems; Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epoxy Compounds; Humans; Molecular Conformation; Pancreatic Neoplasms; Phenanthrenes; Prodrugs; Structure-Activity Relationship	2021
Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer. Theranostics, 2022, Volume: 12, Issue:3 Topics: Animals; Cell Line, Tumor; Dextrans; Diterpenes; Epoxy Compounds; Mice; Molecular Targeted Therapy; Mutation; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins p21(ras); Tumor Microenvironment	2022
Development of a novel oral complex lipid emulsion containing triptolide for targeting pancreatic cancer. Pharmaceutical development and technology, 2022, Volume: 27, Issue:8 Topics: Animals; Diterpenes; Emulsions; Glycyrrhizic Acid; Lipids; Mice; Pancreatic Neoplasms; Rats; Rats, Sprague-Dawley	2022
Synergism and attenuation of triptolide through prodrug engineering combined with liposomal scaffold strategy to enhance inhibition in pancreatic cancer. International journal of pharmaceutics, 2023, Dec-15, Volume: 648 Topics: Animals; Cell Line, Tumor; Liposomes; Mice; Pancreatic Neoplasms; Phospholipids; Prodrugs	2023
Sequential delivery of nanoformulated α-mangostin and triptolide overcomes permeation obstacles and improves therapeutic effects in pancreatic cancer. Biomaterials, 2020, Volume: 241 Topics: Carcinoma, Pancreatic Ductal; Diterpenes; Epoxy Compounds; Humans; Pancreatic Neoplasms; Phenanthrenes; Tumor Microenvironment; Xanthones	2020
Triptolide inhibits pancreatic cancer cell proliferation and migration via down-regulating PLAU based on network pharmacology of Tripterygium wilfordii Hook F. European journal of pharmacology, 2020, Aug-05, Volume: 880 Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Diterpenes; Down-Regulation; Drugs, Chinese Herbal; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Phenanthrenes; Tripterygium; Urokinase-Type Plasminogen Activator	2020
The Anti-Tumor Mechanism and Target of Triptolide Based on Network Pharmacology and Molecular Docking. Recent patents on anti-cancer drug discovery, 2021, Volume: 16, Issue:3 Topics: Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Chemokine CCL2; Collagen Type I, alpha 1 Chain; Colorectal Neoplasms; Cyclooxygenase 2; Diterpenes; Epoxy Compounds; Heme Oxygenase-1; Humans; Interleukin-17; Interleukin-6; Interleukin-8; Lung Neoplasms; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 8; Molecular Docking Simulation; Molecular Targeted Therapy; Network Pharmacology; NF-kappa B; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-jun; Receptor, ErbB-2; STAT1 Transcription Factor; Structure-Activity Relationship; Toll-Like Receptors; Vascular Endothelial Growth Factor A	2021
Triptolide and celastrol loaded silk fibroin nanoparticles show synergistic effect against human pancreatic cancer cells. Nanoscale, 2017, Aug-17, Volume: 9, Issue:32 Topics: Cell Line, Tumor; Diterpenes; Drug Synergism; Epoxy Compounds; Fibroins; Humans; Nanoparticles; Pancreatic Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Triterpenes	2017
Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line. BMC cancer, 2018, Nov-12, Volume: 18, Issue:1 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Computational Biology; Diterpenes; DNA Damage; DNA Repair; Epoxy Compounds; Gene Expression; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; Humans; Pancreatic Neoplasms; Phenanthrenes; ras Proteins; Signal Transduction; Transcriptome	2018
Triptolide suppresses pancreatic cancer cell proliferation by inhibiting hedgehog signaling pathway activity. Science China. Life sciences, 2019, Volume: 62, Issue:10 Topics: 3T3 Cells; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; Hedgehog Proteins; Humans; Mice; Pancreatic Neoplasms; Phenanthrenes; Signal Transduction; Small Molecule Libraries	2019
Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release. ACS nano, 2019, 04-23, Volume: 13, Issue:4 Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Delayed-Action Preparations; Diterpenes; Drug Delivery Systems; Drug Liberation; Epoxy Compounds; Humans; Hydrogen-Ion Concentration; Lysosomes; Male; Mice, Inbred BALB C; Mice, Nude; Micelles; Mutation; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins p21(ras)	2019
Triptolide enhances TRAIL sensitivity of pancreatic cancer cells by activating autophagy via downregulation of PUM1. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 62 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Diterpenes; Down-Regulation; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Mice, Nude; Pancreatic Neoplasms; Phenanthrenes; RNA-Binding Proteins; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays	2019
Triptolide induces the expression of miR-142-3p: a negative regulator of heat shock protein 70 and pancreatic cancer cell proliferation. Molecular cancer therapeutics, 2013, Volume: 12, Issue:7 Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; Female; Gene Expression; HEK293 Cells; HSP70 Heat-Shock Proteins; Humans; Mice; Mice, SCID; MicroRNAs; Pancreatic Neoplasms; Phenanthrenes; Random Allocation; Transfection; Xenograft Model Antitumor Assays	2013
Triptolide induces apoptosis and inhibits the growth and angiogenesis of human pancreatic cancer cells by downregulating COX-2 and VEGF. Oncology research, 2013, Volume: 20, Issue:8 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diterpenes; Down-Regulation; Epoxy Compounds; Female; Humans; Male; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenanthrenes; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2013
miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death. Molecular cancer, 2013, Sep-11, Volume: 12, Issue:1 Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents; Base Sequence; Binding Sites; Cell Death; Cell Line, Tumor; Diterpenes; Epithelium; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice; Mice, SCID; MicroRNAs; Myeloid Cell Leukemia Sequence 1 Protein; Organophosphates; Pancreatic Ducts; Pancreatic Neoplasms; Phenanthrenes; RNA Interference; Up-Regulation; Xenograft Model Antitumor Assays	2013
Triptolide-induced cell death in pancreatic cancer is mediated by O-GlcNAc modification of transcription factor Sp1. The Journal of biological chemistry, 2013, Nov-22, Volume: 288, Issue:47 Topics: Acetylglucosamine; Active Transport, Cell Nucleus; Antineoplastic Agents, Alkylating; Cell Death; Cell Line, Tumor; Cell Nucleus; Cell Survival; Diterpenes; DNA-Binding Proteins; Down-Regulation; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Glycosylation; Heat Shock Transcription Factors; HSP70 Heat-Shock Proteins; Humans; N-Acetylglucosaminyltransferases; Neoplasm Proteins; NF-kappa B; Pancreatic Neoplasms; Phenanthrenes; Signal Transduction; Sp1 Transcription Factor; Transcription Factors	2013
Synergism of cytotoxicity effects of triptolide and artesunate combination treatment in pancreatic cancer cell lines. Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:9 Topics: Animals; Antimalarials; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Artemisinins; Artesunate; Blotting, Western; Cell Proliferation; Diterpenes; Drug Synergism; Epoxy Compounds; HSP27 Heat-Shock Proteins; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phenanthrenes; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2013
Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation. International journal of cancer, 2014, May-15, Volume: 134, Issue:10 Topics: Aldehyde Dehydrogenase 1 Family; Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Blotting, Western; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chick Embryo; Diterpenes; Down-Regulation; Epithelial-Mesenchymal Transition; Epoxy Compounds; Humans; Isoenzymes; Mice; Mice, Inbred Strains; Mice, Nude; Neoplastic Stem Cells; NF-kappa B; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-rel; Retinal Dehydrogenase; RNA Interference; Spheroids, Cellular; Xenograft Model Antitumor Assays	2014
Triptolide sensitizes pancreatic cancer cells to TRAIL-induced activation of the death receptor pathway. Cancer letters, 2014, Jun-28, Volume: 348, Issue:1-2 Topics: Animals; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cell Line, Tumor; Cell Survival; Diterpenes; Drug Resistance, Neoplasm; Enzyme Activation; Epoxy Compounds; Humans; Lysosomes; Mice; Mitochondrial Membranes; Pancreatic Neoplasms; Permeability; Phenanthrenes; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Interference; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transfection	2014
Triptolide activates unfolded protein response leading to chronic ER stress in pancreatic cancer cells. American journal of physiology. Gastrointestinal and liver physiology, 2014, Jun-01, Volume: 306, Issue:11 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis Regulatory Proteins; Beclin-1; Cell Line, Tumor; Chronic Disease; Diterpenes; DNA-Binding Proteins; Down-Regulation; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Heat-Shock Proteins; Membrane Proteins; Pancreatic Neoplasms; Phenanthrenes; Regulatory Factor X Transcription Factors; Stress, Physiological; Transcription Factors; Unfolded Protein Response	2014
Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer. Oncology reports, 2014, Volume: 32, Issue:1 Topics: Animals; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Carbonic Anhydrases; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Chick Embryo; Cobalt; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Neoplasms, Experimental; Neoplastic Stem Cells; Pancreatic Neoplasms; Phenanthrenes	2014
LB-1 Exerts Antitumor Activity in Pancreatic Cancer by Inhibiting HIF-1α and Stat3 Signaling. Journal of cellular physiology, 2015, Volume: 230, Issue:9 Topics: Cell Hypoxia; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Pathologic; Pancreatic Neoplasms; Phenanthrenes; Promoter Regions, Genetic; Signal Transduction; STAT3 Transcription Factor; TOR Serine-Threonine Kinases	2015
Pharmacokinetics and tissue distribution study in mice of triptolide-loaded lipid emulsion and accumulation effect on pancreas. Drug delivery, 2016, Volume: 23, Issue:4 Topics: Animals; Chemistry, Pharmaceutical; Diterpenes; Drug Carriers; Drug Delivery Systems; Epoxy Compounds; Female; Humans; Lipids; Mice; Pancreas; Pancreatic Neoplasms; Phenanthrenes; Tissue Distribution	2016
Primary and liver metastasis-derived cell lines from KrasG12D; Trp53R172H; Pdx-1 Cre animals undergo apoptosis in response to triptolide. Pancreas, 2015, Volume: 44, Issue:4 Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Immunocompetence; Mice; Mice, Transgenic; Pancreatic Neoplasms; Phenanthrenes	2015
Triptolide suppresses proliferation, hypoxia-inducible factor-1α and c-Myc expression in pancreatic cancer cells. Molecular medicine reports, 2015, Volume: 12, Issue:3 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; Female; Gene Expression; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-myc; Signal Transduction; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2015
Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Jan-15, Volume: 22, Issue:2 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Diterpenes; Drug Delivery Systems; Epoxy Compounds; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Organophosphates; Pancreatic Neoplasms; Phenanthrenes; Stromal Cells; Tumor Microenvironment	2016
Minnelide Overcomes Oxaliplatin Resistance by Downregulating the DNA Repair Pathway in Pancreatic Cancer. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2016, Volume: 20, Issue:1 Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Survival; Diterpenes; DNA Damage; DNA Repair; Down-Regulation; Epoxy Compounds; Female; Humans; Mice; Organophosphates; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Phenanthrenes; Random Allocation	2016
Minnelide effectively eliminates CD133(+) side population in pancreatic cancer. Molecular cancer, 2015, Nov-23, Volume: 14 Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Survival; Diterpenes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Epoxy Compounds; Glycoproteins; Humans; Neoplastic Stem Cells; Organophosphates; Pancreatic Neoplasms; Peptides; Phenanthrenes; Side-Population Cells	2015
Toward targeted therapy in chemotherapy-resistant pancreatic cancer with a smart triptolide nanomedicine. Oncotarget, 2016, Feb-16, Volume: 7, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Aptamers, Nucleotide; Deoxycytidine; Diterpenes; Drug Resistance, Neoplasm; Epoxy Compounds; Female; Gemcitabine; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred BALB C; Mice, Nude; Nanomedicine; Oligodeoxyribonucleotides; Pancreatic Neoplasms; Phenanthrenes; Polyethylene Glycols; Polymers; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2016
Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3-MYC Interactions as a Target in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2016, Dec-15, Volume: 22, Issue:24 Topics: Amides; Animals; Carcinoma, Pancreatic Ductal; Cell Line; Cell Line, Tumor; Cell Proliferation; Diterpenes; DNA Helicases; DNA-Binding Proteins; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Mice; Mice, SCID; NIH 3T3 Cells; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-myc; Pyridines; rho-Associated Kinases; Signal Transduction; Transcription, Genetic	2016
Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms. Gastroenterology, 2009, Volume: 136, Issue:5 Topics: Apoptosis; Calcium; Caspase 3; Cathepsin B; Cell Line, Tumor; Cytosol; Diterpenes; Epoxy Compounds; HSP70 Heat-Shock Proteins; Humans; Lysosomal-Associated Membrane Protein 2; Lysosomes; Pancreatic Neoplasms; Phenanthrenes; Quercetin; RNA, Small Interfering	2009
Triptolide and management of systemic malignancies besides pancreatic carcinomas. World journal of gastroenterology, 2009, Feb-28, Volume: 15, Issue:8 Topics: Anti-Inflammatory Agents, Non-Steroidal; bcl-2-Associated X Protein; Cell Division; Diterpenes; Epoxy Compounds; Humans; Neoplasms; Pancreatic Neoplasms; Phenanthrenes; Up-Regulation	2009
TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2010, Volume: 14, Issue:2 Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Survival; Diterpenes; Epoxy Compounds; Humans; Pancreatic Neoplasms; Phenanthrenes; TNF-Related Apoptosis-Inducing Ligand	2010
Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways. Gastroenterology, 2010, Volume: 139, Issue:2 Topics: Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 5; Beclin-1; Caspase 3; Cell Line, Tumor; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Phenanthrenes; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases	2010
Autophagy in pancreatic cancer: an emerging mechanism of cell death. Autophagy, 2010, Volume: 6, Issue:7 Topics: Antineoplastic Agents, Alkylating; Autophagy; Cell Death; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Humans; Pancreatic Neoplasms; Phenanthrenes	2010
In vitro synergistic cytotoxic effect of triptolide combined with hydroxycamptothecin on pancreatic cancer cells. The American journal of Chinese medicine, 2011, Volume: 39, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Caspase 3; Caspase 9; Cell Line, Tumor; Diterpenes; Drug Synergism; Epoxy Compounds; Humans; NF-kappa B; Pancreatic Neoplasms; Phenanthrenes; Phytotherapy; Plant Extracts; Signal Transduction; Tripterygium	2011
Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model. Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:1 Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phenanthrenes; RNA Interference; RNA, Small Interfering; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays	2012
Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression. Journal of cancer research and clinical oncology, 2012, Volume: 138, Issue:9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Flow Cytometry; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phenanthrenes; Receptors, Tumor Necrosis Factor, Member 6b; RNA Interference; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays	2012
Triptolide cooperates with Cisplatin to induce apoptosis in gemcitabine-resistant pancreatic cancer. Pancreas, 2012, Volume: 41, Issue:7 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplatin; Deoxycytidine; Diterpenes; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Epoxy Compounds; Female; Gemcitabine; HSP27 Heat-Shock Proteins; Humans; Mice; Mice, Nude; Mitochondria; Neoplasm Transplantation; Pancreatic Neoplasms; Phenanthrenes; RNA, Small Interfering; Transfection	2012
Pancreas cancer meets the thunder god. Science translational medicine, 2012, Oct-17, Volume: 4, Issue:156 Topics: Animals; Antineoplastic Agents, Alkylating; Carcinoma, Pancreatic Ductal; Clinical Trials as Topic; Diterpenes; Drug Evaluation, Preclinical; Epoxy Compounds; Humans; Medical Oncology; Medicine, Chinese Traditional; Organophosphates; Pancreatic Neoplasms; Phenanthrenes; Research Design; Translational Research, Biomedical	2012
A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer. Science translational medicine, 2012, Oct-17, Volume: 4, Issue:156 Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Survival; Diterpenes; Drug Screening Assays, Antitumor; Epoxy Compounds; Female; Humans; Mice; Mice, Nude; Mice, SCID; Neoplasm Transplantation; Organophosphates; Pancreatic Neoplasms; Phenanthrenes; Phosphoric Monoester Hydrolases	2012
Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide. Journal of molecular medicine (Berlin, Germany), 2006, Volume: 84, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Carcinoma; Caspases; Diterpenes; Enzyme Activation; Epoxy Compounds; HeLa Cells; Humans; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship; Tumor Cells, Cultured	2006
Enhanced antitumor effect of combined triptolide and ionizing radiation. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Aug-15, Volume: 13, Issue:16 Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Diterpenes; Epoxy Compounds; G2 Phase; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Phenanthrenes; Transplantation, Heterologous	2007
Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70. Cancer research, 2007, Oct-01, Volume: 67, Issue:19 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Caspase 3; Cell Growth Processes; Cell Line, Tumor; Cytochromes c; Diterpenes; Epoxy Compounds; HSP70 Heat-Shock Proteins; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phenanthrenes; Xenograft Model Antitumor Assays	2007
Apoptosis of human pancreatic cancer cells induced by Triptolide. World journal of gastroenterology, 2008, Mar-14, Volume: 14, Issue:10 Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Time Factors; Tripterygium; Up-Regulation	2008