Page last updated: 2024-09-02

triptolide and Neoplasms

triptolide has been researched along with Neoplasms in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.78)18.2507
2000's4 (11.11)29.6817
2010's22 (61.11)24.3611
2020's9 (25.00)2.80

Authors

AuthorsStudies
Buckton, LK; McAlpine, SR; McConnell, JR1
Ahn, MR; Maruta, H1
Emami, SA; Taleghani, A; Tayarani-Najaran, Z1
Kinghorn, AD; Ren, Y1
Hua, D; Wu, X1
Cai, XJ; Chen, YH; Jin, J; Li, JM; Xu, YY; Yuan, Y; Zhang, RY1
Dai, L; He, GN; Song, J1
Deng, G; Guo, Q; Lin, P; Wang, S; Xia, X; Xu, R1
Chen, L; Fu, CM; Li, J; Li, JX; Luo, RF; Luo, YY; Shi, JF; Zhang, JM1
Datan, E; He, QL; Lin, GQ; Liu, JO; Minn, I; Pomper, MG; Romo, D; Tong, L; Yu, B; Zhao, Q1
Dhanasekaran, DN; Han, Y; Jo, H; Kim, H; Kim, S; Kim, SJ; Lee, J; Song, YS; Wang, W; Yang, KM1
Huang, SW; Lu, ST; Wu, B; Xu, HB; Zhang, LJ; Zhuo, RX1
Sun, X; Yan, P1
Liu, BW; Luan, ZH; Ren, JH; Wang, YH; Wei, YM; Xue, HQ1
Wang, B; Wang, Y; Yang, X1
Hua, ZC; Lin, Y; Lu, M; Yang, X; Zhang, J; Zheng, W; Zhuang, H1
Ben Yebdri, F; Goulet, ML; Hiscott, J; Lin, R; Stojdl, DF; Tang, VA; Van Grevenynghe, J; Wu, JH1
Bai, XY; Wang, CH; Wang, CY1
Park, B1
Al-Assaad, AS; Angagaw, MH; Ayers, M; Blanchard, R; Booher, RN; Dolinski, BM; Fawell, SE; Gilliland, G; Harmonay, L; Hatch, H; Hirsch, HA; Im, EK; Kondic, AG; Lee, J; Lennon, XQ; Loboda, A; Long, BJ; Mauro, D; Merkel, CE; Miselis, N; Monahan, JW; Nebozhyn, M; Nguyen, T; Pucci, V; Schuller, AG; Shi, B; Strack, P; Wang, Y; Zawel, L; Zhang, T1
Fan, Y; Shan, Y; Wang, C; Xu, W; Xu, X; Yang, J; Zhuang, B1
Chen, MW; Chen, Y; Cheng, KJ; Jiang, QW; Lv, M; Mei, XL; Qin, WM; Qiu, JG; Shi, Z; Wei, MN; Wei, X; Xue, YQ; Yang, Y; Zhang, WJ; Zhang, X; Zheng, DW1
Datan, E; He, QL; Head, SA; Liu, JO; Minn, I; Pomper, MG; Wang, Q; Xu, P; Yu, B1
Li, R; Shen, C; Tao, Y; Tian, X; Wang, F; Wang, Z; Zhang, Q; Zhang, X; Zhang, Y1
Kapoor, S1
Bunz, F1
Liao, M; Luo, Y; Shi, C1
Pan, J1
Dou, QP; Liu, J; Yang, H1
Chen, Y; Dai, M; Ding, J; Feng, JM; Jiang, Y; Li, YC; Li, Z; Luo, ZG; Miao, ZH; Tong, LJ; Yu, B; Zhou, ZL1
Liu, Z; Ma, L; Zhou, GB1
Cao, X; Chen, L; Jiang, F; Lin, B; Liu, J; Lu, N; Wang, G; Wu, H; Yan, T; Yan, X; Zeng, JZ; Zeng, W; Zhang, C; Zhang, XK; Zhou, H1
Capranico, G; Ding, J; He, JX; Li, YC; Manzo, SG; Marinello, J; Miao, ZH; Wang, YQ; Zhou, ZL1
Chen, X; Lang, L; Li, Y; Liu, X; Tang, K; Wang, C1
Chang, W; Kao, PN; Lee, KY; Qiu, D; Rosen, GD1
Anderson, E; Chang, WT; Gotmare, S; Kang, JJ; Lee, KY; Rosen, GD; Ross, JA; Wei, K1

Reviews

16 review(s) available for triptolide and Neoplasms

ArticleYear
Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach.
    Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17

    Topics: HSP90 Heat-Shock Proteins; Humans; Neoplasms; Transcription Factors

2015
From bench (laboratory) to bed (hospital/home): How to explore effective natural and synthetic PAK1-blockers/longevity-promoters for cancer therapy.
    European journal of medicinal chemistry, 2017, Dec-15, Volume: 142

    Topics: Animals; Antineoplastic Agents; Click Chemistry; Drug Discovery; Humans; Longevity; Neoplasms; p21-Activated Kinases; Protein Kinase Inhibitors

2017
Artemisia: a promising plant for the treatment of cancer.
    Bioorganic & medicinal chemistry, 2020, 01-01, Volume: 28, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Artemisia; Cell Proliferation; Humans; Molecular Structure; Neoplasms; Neoplasms, Experimental; Plant Extracts; Plants, Medicinal

2020
Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.
    European journal of medicinal chemistry, 2022, Apr-05, Volume: 233

    Topics: Humans; Neoplasms; Protein Processing, Post-Translational; Small Ubiquitin-Related Modifier Proteins; Sumoylation; Ubiquitin

2022
A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 162

    Topics: Diterpenes; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Triterpenes

2023
[Research progress on anti-tumor effects and mechanisms of triptolide and its combined application].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019, Volume: 44, Issue:16

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Cycle Checkpoints; Diterpenes; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Tripterygium

2019
Triptolide: reflections on two decades of research and prospects for the future.
    Natural product reports, 2021, 04-28, Volume: 38, Issue:4

    Topics: Animals; Autoimmune Diseases; Diterpenes; Drug Design; Drug Discovery; Epoxy Compounds; Forecasting; Humans; Inflammation; Neoplasms; Phenanthrenes; Tripterygium

2021
Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy.
    Biomolecules, 2021, 07-27, Volume: 11, Issue:8

    Topics: Animals; Antigens, CD; Antineoplastic Agents; B7 Antigens; B7-H1 Antigen; Camptothecin; CTLA-4 Antigen; Diterpenes; Epoxy Compounds; Flavonoids; Hepatitis A Virus Cellular Receptor 2; Humans; Immune Checkpoint Inhibitors; Immunotherapy; Isothiocyanates; Lymphocyte Activation Gene 3 Protein; Mice; Neoplasms; Phenanthrenes; Phytochemicals; Plant Extracts; Programmed Cell Death 1 Receptor; Receptors, Immunologic; Saponins; Sulfoxides; Terpenes; Tumor Microenvironment

2021
Triptolide: A new star for treating human malignancies.
    Journal of cancer research and therapeutics, 2018, Volume: 14, Issue:Supplement

    Topics: Antineoplastic Agents, Alkylating; Diterpenes; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Prognosis

2018
Triptolide, A Potential Autophagy Modulator.
    Chinese journal of integrative medicine, 2019, Volume: 25, Issue:3

    Topics: Animals; Apoptosis; Autophagy; Diterpenes; Epoxy Compounds; Humans; Neoplasms; Neuroprotective Agents; Phenanthrenes; Podocytes

2019
The Study of Cellular Mechanism of Triptolide in the Treatment of Cancer, Bone Loss and Cardiovascular Disease and Triptolide's Toxicity.
    Current stem cell research & therapy, 2020, Volume: 15, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arthritis, Rheumatoid; Autophagy; Cardiovascular Diseases; Diterpenes; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Neoplasms; Osteoporosis; Phenanthrenes; Plant Extracts; Signal Transduction; Tripterygium

2020
Traditional Chinese medicine: a treasured natural resource of anticancer drug research and development.
    The American journal of Chinese medicine, 2014, Volume: 42, Issue:3

    Topics: Alkaloids; Amphibian Venoms; Animals; Antineoplastic Agents, Phytogenic; Berberine; Diterpenes; Drug Combinations; Drug Discovery; Drugs, Chinese Herbal; Epoxy Compounds; Flavonoids; Humans; Matrines; Medicine, Chinese Traditional; Molecular Conformation; Molecular Targeted Therapy; Neoplasms; Phenanthrenes; Plants, Medicinal; Podophyllotoxin; Quinolizines

2014
[Advance in the anti-tumor mechanism of triptolide].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2009, Volume: 34, Issue:16

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Tripterygium

2009
RNA polymerase - an important molecular target of triptolide in cancer cells.
    Cancer letters, 2010, Jun-28, Volume: 292, Issue:2

    Topics: Animals; Cell Division; Diterpenes; DNA-Directed RNA Polymerases; Epoxy Compounds; Humans; Neoplasms; Oncogenes; Phenanthrenes

2010
Targeting tumor proteasome with traditional Chinese medicine.
    Current drug discovery technologies, 2010, Volume: 7, Issue:1

    Topics: Animals; Antineoplastic Agents, Phytogenic; Benzyl Compounds; Curcumin; Diterpenes; Drug Delivery Systems; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Medicine, Chinese Traditional; Molecular Structure; Naphthoquinones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phenols; Proteasome Endopeptidase Complex; Signal Transduction; Triterpenes

2010
The main anticancer bullets of the Chinese medicinal herb, thunder god vine.
    Molecules (Basel, Switzerland), 2011, Jun-23, Volume: 16, Issue:6

    Topics: Animals; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Signal Transduction; Tripterygium; Triterpenes

2011

Other Studies

20 other study(ies) available for triptolide and Neoplasms

ArticleYear
Development of Potential Antitumor Agents from the Scaffolds of Plant-Derived Terpenoid Lactones.
    Journal of medicinal chemistry, 2020, 12-24, Volume: 63, Issue:24

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biological Products; Diterpenes; Humans; Neoplasms; Sesquiterpenes; Structure-Activity Relationship; Triterpenes

2020
Modulating tumour vascular normalisation using triptolide-loaded NGR-functionalized liposomes for enhanced cancer radiotherapy.
    Journal of liposome research, 2023, Volume: 33, Issue:3

    Topics: Animals; Cell Line, Tumor; Diterpenes; Drug Delivery Systems; Humans; Lipopolysaccharides; Liposomes; Mice; Neoplasms

2023
Combination of ferroptosis and pyroptosis dual induction by triptolide nano-MOFs for immunotherapy of Melanoma.
    Journal of nanobiotechnology, 2023, Oct-19, Volume: 21, Issue:1

    Topics: Cell Line, Tumor; Ferroptosis; Humans; Immunotherapy; Lung Neoplasms; Melanoma; Metal-Organic Frameworks; Neoplasms; Pyroptosis; Reactive Oxygen Species

2023
Codelivery of doxorubicin and triptolide with reduction-sensitive lipid-polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Diterpenes; Doxorubicin; Drug Delivery Systems; Drug Synergism; Epoxy Compounds; Flow Cytometry; Humans; Lactic Acid; Lipids; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; Oxidation-Reduction; Particle Size; Phenanthrenes; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer

2017
Herbal compound triptolide synergistically enhanced antitumor activity of vasostatin120-180.
    Anti-cancer drugs, 2013, Volume: 24, Issue:9

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Calreticulin; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; Diterpenes; Drug Synergism; Drugs, Chinese Herbal; Epoxy Compounds; Ethnopharmacology; HCT116 Cells; Humans; Mice; Mice, Nude; Neoplasms; Neovascularization, Pathologic; Peptide Fragments; Phenanthrenes; Random Allocation; Recombinant Proteins; Tripterygium; Xenograft Model Antitumor Assays

2013
Triptolide-mediated inhibition of interferon signaling enhances vesicular stomatitis virus-based oncolysis.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2013, Volume: 21, Issue:11

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Combined Modality Therapy; Diterpenes; Epoxy Compounds; Female; HEK293 Cells; Humans; Interferons; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Neoplasms, Experimental; Oncolytic Virotherapy; Oncolytic Viruses; Phenanthrenes; Signal Transduction; Vesicular stomatitis Indiana virus; Virus Replication; Xenograft Model Antitumor Assays

2013
Triptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cells.
    Biochimie, 2014, Volume: 105

    Topics: Animals; Bone Resorption; Cell Differentiation; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Humans; Mice; Neoplasms; Osteoclasts; Osteoporosis; Phenanthrenes; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Signal Transduction

2014
MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Diterpenes; Drug Resistance, Neoplasm; Drug Synergism; Epoxy Compounds; Female; Gene Dosage; Humans; Indolizines; Male; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Phenanthrenes; Pyridinium Compounds; RNA, Messenger; Sulfonamides; Xenograft Model Antitumor Assays

2014
Inhibition of Cancer Angiogenesis Using Triptolide Nanoparticles.
    Journal of biomedical nanotechnology, 2015, Volume: 11, Issue:5

    Topics: Animals; Antineoplastic Agents, Alkylating; Cells, Cultured; Diterpenes; Drug Carriers; Epoxy Compounds; Human Umbilical Vein Endothelial Cells; Humans; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Nanoparticles; Neoplasms; Neovascularization, Pathologic; Phenanthrenes; Rats; Rats, Sprague-Dawley

2015
Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine.
    Oncotarget, 2015, Oct-20, Volume: 6, Issue:32

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Epoxy Compounds; G2 Phase Cell Cycle Checkpoints; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Inhibitory Concentration 50; Mice, Inbred BALB C; Mice, Nude; Molecular Chaperones; Neoplasms; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Time Factors; Transfection; Tripterygium; Triterpenes; Tumor Burden; Xenograft Model Antitumor Assays

2015
Targeted Delivery and Sustained Antitumor Activity of Triptolide through Glucose Conjugation.
    Angewandte Chemie (International ed. in English), 2016, 09-19, Volume: 55, Issue:39

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Diterpenes; Drug Delivery Systems; Epoxy Compounds; Glucose; HEK293 Cells; Humans; Mice; Neoplasms; Phenanthrenes

2016
Triptolide inhibits tumor growth by induction of cellular senescence.
    Oncology reports, 2017, Volume: 37, Issue:1

    Topics: Animals; Cell Proliferation; Cellular Senescence; Diterpenes; Epoxy Compounds; Hep G2 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Phenanthrenes; Signal Transduction; Up-Regulation; Xenograft Model Antitumor Assays

2017
Triptolide and management of systemic malignancies besides pancreatic carcinomas.
    World journal of gastroenterology, 2009, Feb-28, Volume: 15, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; bcl-2-Associated X Protein; Cell Division; Diterpenes; Epoxy Compounds; Humans; Neoplasms; Pancreatic Neoplasms; Phenanthrenes; Up-Regulation

2009
Ancient drugs, modern targets.
    Cancer biology & therapy, 2009, Volume: 8, Issue:21

    Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Antineoplastic Agents, Alkylating; Diterpenes; Drug Discovery; Drugs, Chinese Herbal; Epoxy Compounds; Humans; Membrane Proteins; Neoplasms; Phenanthrenes

2009
Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide.
    Molecular cancer, 2010, Oct-11, Volume: 9

    Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Diterpenes; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Flow Cytometry; Fluorescent Antibody Technique; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoprecipitation; Neoplasms; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Vascular Endothelial Growth Factors

2010
Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.
    PloS one, 2012, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Caspase 8; Caspase 9; Cell Line; Cell Line, Tumor; Diterpenes; Drugs, Chinese Herbal; Enzyme Activation; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-akt; Retinoid X Receptor alpha; Signal Transduction; Tumor Necrosis Factor-alpha

2012
Natural product triptolide mediates cancer cell death by triggering CDK7-dependent degradation of RNA polymerase II.
    Cancer research, 2012, Oct-15, Volume: 72, Issue:20

    Topics: Base Sequence; Biological Products; Cell Death; Cell Line, Tumor; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Diterpenes; DNA Primers; Epoxy Compounds; Humans; Neoplasms; Phenanthrenes; Phosphorylation; Proteolysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II

2012
[Identification of two small molecule inhibitors of hypoxia-inducible factor 1 with different cell-based screening model].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2012, Volume: 37, Issue:14

    Topics: Cell Line, Tumor; Cell Proliferation; Diterpenes; Drug Evaluation, Preclinical; Epoxy Compounds; Humans; Hypoxia-Inducible Factor 1; Lignans; Luciferases; Models, Biological; Neoplasms; Phenanthrenes

2012
PG490 (triptolide) cooperates with tumor necrosis factor-alpha to induce apoptosis in tumor cells.
    The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Base Sequence; Diterpenes; DNA Primers; Drug Synergism; Epoxy Compounds; Humans; Inhibitor of Apoptosis Proteins; Neoplasms; NF-kappa B; Phenanthrenes; Protein Biosynthesis; Proteins; Transcriptional Activation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases

1999
Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway.
    The Journal of biological chemistry, 2001, Jan-19, Volume: 276, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Cycle; Diterpenes; DNA Primers; DNA, Neoplasm; Doxorubicin; Drug Synergism; Epoxy Compounds; Humans; Mice; Neoplasms; Oncogene Protein p21(ras); Phenanthrenes; Protein Binding; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001