triptolide has been researched along with Multiple Myeloma in 15 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 12 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, HY; Liao, B; Lin, T; Shen, JZ; Xu, CB | 1 |
| Kim, JH; Park, B | 1 |
| Kizaki, M; Nakazato, T; Sagawa, M | 1 |
| Chen, Y; Wen, L; Yang, LJ; Yi, S; Zeng, LL; Zhang, BP; Zhang, C; Zhao, F; Zhao, J; Zhao, ZC | 1 |
| Huang, J; Jin, J; Pan, HZ; Yang, M | 1 |
| Du, HP; Huang, J; Jin, J; Ma, QL; Shen, JK; Yang, M | 1 |
| Chen, Y; Li, R; Liu, Y; Wen, L; Zhang, C; Zhao, F | 1 |
| Chen, Y; Li, R; Liu, Y; Wen, L; Zeng, LL; Zeng, R; Zhang, C; Zhao, F | 1 |
| Chen, Y; Li, R; Liu, Y; Wen, L; Zeng, L; Zeng, R; Zhang, C; Zhao, F | 1 |
| Chen, Y; Li, R; Wen, L; Zeng, L; Zeng, R; Zhang, C; Zhao, F | 1 |
| Chen, Y; Li, R; Liu, Y; Wen, L; Zeng, LL; Zhang, C; Zhao, F | 1 |
| Huang, X; Jin, J; Yang, M | 1 |
| Chen, XQ; Dong, HJ; Gao, GX; Gu, HT; Wang, YW; Yang, Y | 1 |
| Andrulis, M; Bargou, RC; Beilhack, A; Bogen, B; Bumm, T; Chatterjee, M; Einsele, H; Heimberger, T; Riedel, S; Schraud, H; Stühmer, T | 1 |
| Jie, J; Yinjun, L; Yungui, W | 1 |
15 other study(ies) available for triptolide and Multiple Myeloma
| Article | Year |
|---|---|
[Effects of Triptolide on MMP-9 Expression and Inducing Apoptosis of Multiple Myeloma Cells by Inhibiting SMYD3].
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; Histone-Lysine N-Methyltransferase; Humans; Matrix Metalloproteinase 9; Multiple Myeloma; Phenanthrenes | 2017 |
Triptolide blocks the STAT3 signaling pathway through induction of protein tyrosine phosphatase SHP-1 in multiple myeloma cells.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Multiple Myeloma; Phenanthrenes; Phosphorylation; Protein Binding; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor | 2017 |
Triptolide induces apoptotic cell death of multiple myeloma cells via transcriptional repression of Mcl-1.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Diterpenes; Epoxy Compounds; G1 Phase Cell Cycle Checkpoints; Humans; Intracellular Signaling Peptides and Proteins; Medicine, Chinese Traditional; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Phenanthrenes; Transcription, Genetic | 2014 |
Triptolide Induces Cell Apoptosis by Targeting H3K4me3 and Downstream Effector Proteins in KM3 Multiple Myeloma Cells.
Topics: Apoptosis; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Histones; Humans; Methylation; Multiple Myeloma; Phenanthrenes | 2015 |
Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-kappaB pathways in human multiple myeloma cells.
Topics: Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dexamethasone; Diterpenes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Activation; Epoxy Compounds; Humans; I-kappa B Proteins; Inhibitor of Apoptosis Proteins; Mitochondria; Multiple Myeloma; NF-kappa B; Phenanthrenes; Phosphatidylinositol 3-Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Receptors, Glucocorticoid; Up-Regulation | 2008 |
Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dexamethasone; Diterpenes; Drug Resistance, Neoplasm; Epoxy Compounds; Humans; Interleukin-6; Multiple Myeloma; Phenanthrenes; Phosphorylation; Receptors, Glucocorticoid; Up-Regulation | 2009 |
Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; G1 Phase; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Interphase; Methylation; Multiple Myeloma; Phenanthrenes; Resting Phase, Cell Cycle | 2010 |
Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Bisbenzimidazole; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Diterpenes; DNA-Binding Proteins; Drugs, Chinese Herbal; Epoxy Compounds; Flow Cytometry; Fluorescent Dyes; Histone-Lysine N-Methyltransferase; Histones; Humans; Inhibitor of Apoptosis Proteins; Methylation; Multiple Myeloma; Nuclear Proteins; Phenanthrenes; Transcription Factors | 2010 |
Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; G2 Phase; Gene Expression Regulation, Neoplastic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Multiple Myeloma; Phenanthrenes; RNA, Messenger | 2010 |
Triptolide-induced apoptosis by inactivating nuclear factor-kappa B apoptotic pathway in multiple myeloma in vitro.
Topics: Apoptosis; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Humans; Multiple Myeloma; NF-kappa B; Phenanthrenes; Signal Transduction | 2011 |
Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Diterpenes; DNA Methylation; Epoxy Compounds; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Multiple Myeloma; Phenanthrenes | 2012 |
Triptolide enhances the sensitivity of multiple myeloma cells to dexamethasone via microRNAs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dexamethasone; Diterpenes; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Synergism; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Multiple Myeloma; Phenanthrenes | 2012 |
[Effects of triptolide on bortezomib-induced apoptosis in multiple myeloma cells].
Topics: Apoptosis; Boronic Acids; Bortezomib; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Humans; Multiple Myeloma; Phenanthrenes; Pyrazines | 2012 |
The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Boronic Acids; Bortezomib; Cells, Cultured; Diterpenes; DNA-Binding Proteins; Down-Regulation; Epoxy Compounds; Female; Gene Knockdown Techniques; Heat Shock Transcription Factors; Heat-Shock Proteins; Humans; Immunohistochemistry; Isoxazoles; Mice; Mice, Inbred BALB C; Multiple Myeloma; Neoplasm Transplantation; Phenanthrenes; Plasma Cells; Proteasome Endopeptidase Complex; Pyrazines; Resorcinols; RNA, Small Interfering; Transcription Factors; Transplantation, Heterologous | 2013 |
Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Caspase 8; Caspase 9; Caspases; Cell Proliferation; Diterpenes; Enzyme Activation; Epoxy Compounds; Humans; Multiple Myeloma; NF-kappa B; Phenanthrenes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Transcription Factors; Tumor Cells, Cultured | 2005 |