triptolide has been researched along with Leukemia, Myeloid, Acute in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, L; Kang, D; Liu, Y; Pan, X; Song, Y; Wang, D; Wang, J; Zhu, X | 1 |
| Lu, YJ; Ma, LM; Tian, WW; Wang, T; Wang, X | 1 |
| Deng, M; Guo, C; Li, Z; Lin, Y; Pu, X; Qiu, Y; Shi, Y; Song, H; Xu, B; Ye, J; Zeng, H; Zha, J; Zhao, H; Zhou, Y | 1 |
| Carter, BZ; Deng, MM; Fang, ZH; He, LL; Lin, ZJ; Liu, L; Shi, YF; Xu, B; Ye, J; Yuan, DL | 1 |
| Deng, M; Feng, J; Jiang, Y; Jiang, Z; Li, P; Liao, N; Shi, P; Song, H; Xu, B; Zha, J; Zhao, H | 1 |
| Gan, X; Lu, X; Ma, A; Shen, J; Wu, B; Wu, Z; Xu, R; Xu, Y; Yang, L; Yu, Q; Yu, X; Zhang, L; Zhang, X; Zhuang, H | 1 |
| Banerjee, S; Dudeja, V; Giri, B; Gupta, VK; Lavania, SP; Modi, S; Roy, P; Saluja, A; Sethi, V; Vickers, SM; Watts, J; Yaffe, B | 1 |
| Chen, F; Guo, X; Liu, Y; Shi, P; Wang, S; Wang, W; Xu, B | 1 |
| Belloc, F; Jeanneteau, M; Lacombe, F; Mahon, FX; Milpied, N; Pigneux, A; Reiffers, J; Uhalde, M | 1 |
| Chen, XQ; Fang, HT; Hu, AM; Hu, Z; Pan, XF; Xu, L; Zhang, FX; Zhou, GB; Zhou, GS | 1 |
| Andreeff, M; Carter, BZ; Dietrich, MF; Mak, DH; Pinilla, C; Reed, JC; Schober, WD; Vassilev, LT | 1 |
11 other study(ies) available for triptolide and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Discovery of a novel water-soluble, rapid-release triptolide prodrug with improved drug-like properties and high efficacy in human acute myeloid leukemia.
Topics: Animals; Diterpenes; Epoxy Compounds; Humans; Leukemia, Myeloid, Acute; Mice; Phenanthrenes; Prodrugs; Water | 2022 |
[Effect of Low-Dose Triptolide and Sorafenib Alone and Their Combination on AML Cell Line MV411 and the Pathway of STAT5].
Topics: Apoptosis; Cell Line, Tumor; Diterpenes; Epoxy Compounds; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Phenanthrenes; Sorafenib; STAT5 Transcription Factor | 2019 |
Low-dose triptolide enhances antitumor effect of JQ1 on acute myeloid leukemia through inhibiting RNA polymerase II in vitro and in vivo.
Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Azepines; Biomarkers, Tumor; Cell Proliferation; Diterpenes; Drug Resistance, Neoplasm; Epoxy Compounds; Female; Gene Expression Regulation, Enzymologic; Humans; In Vitro Techniques; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Middle Aged; Neoplastic Stem Cells; Phenanthrenes; Prognosis; Reactive Oxygen Species; RNA Polymerase II; Signal Transduction; Triazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Combining triptolide with ABT-199 is effective against acute myeloid leukemia through reciprocal regulation of Bcl-2 family proteins and activation of the intrinsic apoptotic pathway.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Blast Crisis; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Child; Diterpenes; Drug Synergism; Epoxy Compounds; Female; Humans; Leukemia, Myeloid, Acute; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitochondria; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2020 |
Low-Dose Triptolide Enhanced Activity of Idarubicin Against Acute Myeloid Leukemia Stem-like Cells Via Inhibiting DNA Damage Repair Response.
Topics: Animals; Diterpenes; DNA Damage; DNA Repair; Drug Synergism; Epoxy Compounds; Humans; Idarubicin; Leukemia, Myeloid, Acute; Mice; Neoplastic Stem Cells; Phenanthrenes | 2021 |
Identification of the UBA2-WTIP fusion gene in acute myeloid leukemia.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Co-Repressor Proteins; Cytoskeletal Proteins; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Leukocytes; Mice; Mice, Inbred NOD; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oncogene Proteins, Fusion; Phenanthrenes; Protein Domains; RNA, Messenger; STAT3 Transcription Factor; STAT5 Transcription Factor; Survival Analysis; Ubiquitin-Activating Enzymes; Xenograft Model Antitumor Assays | 2018 |
Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Diterpenes; Down-Regulation; Drug Evaluation, Preclinical; Epoxy Compounds; Humans; Leukemia, Myeloid, Acute; Mice; Neoplastic Stem Cells; Organophosphates; Phenanthrenes; Proto-Oncogene Proteins c-myc; Tumor Burden; Tumor Stem Cell Assay | 2019 |
Low-dose triptolide in combination with idarubicin induces apoptosis in AML leukemic stem-like KG1a cell line by modulation of the intrinsic and extrinsic factors.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line; Cell Survival; Diterpenes; Epoxy Compounds; Flow Cytometry; Humans; Idarubicin; Immunophenotyping; Leukemia, Myeloid, Acute; Neoplastic Stem Cells; NF-E2-Related Factor 2; Phenanthrenes; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction | 2013 |
Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells.
Topics: Annexin A5; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cytarabine; Diterpenes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Epoxy Compounds; Humans; I-kappa B Proteins; Idarubicin; Leukemia, Myeloid, Acute; Leukocyte Common Antigens; Phenanthrenes; X-Linked Inhibitor of Apoptosis Protein | 2008 |
Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Cell Proliferation; Cells, Cultured; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Core Binding Factor Alpha 2 Subunit; Diterpenes; Epoxy Compounds; Humans; Janus Kinases; Leukemia, Myeloid, Acute; Oncogene Proteins, Fusion; Phenanthrenes; Proto-Oncogene Proteins c-kit; Reverse Transcriptase Polymerase Chain Reaction; RUNX1 Translocation Partner 1 Protein; Signal Transduction; STAT Transcription Factors | 2011 |
Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.
Topics: Aniline Compounds; Antineoplastic Agents, Alkylating; Apoptosis; Diterpenes; Drug Synergism; Epoxy Compounds; Female; Humans; Imidazoles; Leukemia, Myeloid, Acute; Male; Phenanthrenes; Piperazines; Proto-Oncogene Proteins c-mdm2; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53; U937 Cells; X-Linked Inhibitor of Apoptosis Protein | 2008 |