triptolide has been researched along with Innate Inflammatory Response in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 18 (48.65) | 24.3611 |
| 2020's | 12 (32.43) | 2.80 |
| Authors | Studies |
|---|---|
| Fu, P; Guo, F; Huang, R; Li, G; Li, Y; Liang, Y; Ma, L | 1 |
| Bao, YN; Jiang, HY; Jin, Y; Lin, FM | 1 |
| Dai, Y; Ke, X; Shi, J; Tang, X; Yang, J | 1 |
| Gao, J; Liang, Z; Liu, X; Ma, N; Zhao, F | 1 |
| Hsu, CC; Jou, IM; Ko, PY; Kwan, TH; Liu, MY; Tsai, CC; Wu, PT | 1 |
| Feng Shi, J; Han Wu, Y; Jiao Zhang, M; Le Gao, H; Mei Zhong, X; Ming Zhang, J; Peng Wang, S; Qu, Y; Xin Li, J | 1 |
| Ba, X; Chen, Z; Han, L; Huang, Y; Lin, W; Shen, P; Tu, S; Wang, H; Yan, J | 1 |
| Chen, H; Han, L; Miao, Y; Wei, L; Zhang, Z | 1 |
| Huang, C; Li, F; Liu, J; Wan, L; Wang, K; Zhu, Z | 1 |
| Datan, E; He, QL; Lin, GQ; Liu, JO; Minn, I; Pomper, MG; Romo, D; Tong, L; Yu, B; Zhao, Q | 1 |
| Cao, H; Chen, Q; Lei, YQ; Liu, JF; Wang, ZC | 1 |
| Liu, J; Wang, J; Wang, X; Wen, J | 1 |
| Chen, C; Hong, J; Lin, J; Okunieff, P; Wu, B; Yang, S; Zhang, L; Zhang, M; Zhang, SB; Zhang, W; Zhang, Z | 1 |
| Chang, L; Chen, X; Dai, H; Hu, L; Jia, J; Kim, JY; Liu, J; Qiu, M; Raz, DJ; Reckamp, K; Shen, B; Wan, L; Xia, Z; Zheng, L; Zhou, M | 1 |
| Hou, HW; Ji, ZL; Wang, D; Wang, JM; Wu, R | 1 |
| Han, F; Li, S; Liao, T; Liu, M; Liu, X; Luo, Z; Sun, Q; Wei, Y; Zhao, D | 1 |
| Gu, L; Huang, YY; Wang, XM; Xia, N; Yang, HM; Zhang, H; Zhang, JN; Zhang, Q; Zhang, YN | 1 |
| Huang, G; Lu, Q; Luo, G; Sheng, H; Xu, A; Yu, R; Yuan, K; Zhang, S; Zhu, M; Zhu, Q | 1 |
| Li, S; Li, Y; Liu, Y; Ma, Y; Qian, N; Xu, F; Zhao, H; Zhao, N | 1 |
| Ding, S; Feng, X; Li, J; Li, L; Lu, Y; Shen, P; Zhang, Y; Zheng, W | 1 |
| Cheng, S; LeBlanc, KJ; Li, L | 1 |
| Chen, C; Song, RX; Wang, B; Yu, XC; Zhang, JT | 1 |
| Chang, BC; Chen, LM; Guo, X; Li, CJ; Ma, ZJ; Wang, SS; Wang, XY; Xue, M; Yang, W; Zhang, XN; Zhao, R | 1 |
| Hong, Y; Huang, H; Zhou, Y | 1 |
| Gong, Y; Jiao, J; Jing, L; Wang, X; Xue, B | 1 |
| Cao, L; Gao, L; He, C; Qiu, Y; Su, Z; Yuan, Y; Zhu, Y | 1 |
| Aggarwal, BB; Chaturvedi, MM; Park, B; Sung, B; Yadav, VR | 1 |
| Furuya, H; Ratanavaraporn, J; Tabata, Y | 1 |
| Ammit, AJ; Che, W; Chen, Y; Manetsch, M; Seidel, P | 1 |
| Gerdes, S; Han, R; Mrowietz, U; Rostami-Yazdi, M | 1 |
| Fang, W; Lam, CW; Peng, F; Wan, C; Xu, H; Yang, X; Yi, T; Zhang, C | 1 |
| Han, JS; Li, FQ; Liang, XB; Liu, XY; Lu, XZ; Niu, DB; Wang, XM; Xue, B; Zhou, HF | 1 |
| Hansen, TN; Liu, Y; Shepherd, EG; Smith, CV; Welty, SE; Zhao, Q | 1 |
| Liacini, A; Sylvester, J; Zafarullah, M | 1 |
| Imada, K; Ito, A; Jia, H; Lin, N; Liu, C; Wu, H; Xiao, C | 1 |
| Feng, D; Mei, Y; Wang, Y; Xu, L | 1 |
| Gao, M; Krishna, G; Liu, K; Raffin, TA; Rosen, GD; Shigemitsu, H | 1 |
2 review(s) available for triptolide and Innate Inflammatory Response
| Article | Year |
|---|---|
Triptolide: reflections on two decades of research and prospects for the future.
Topics: Animals; Autoimmune Diseases; Diterpenes; Drug Design; Drug Discovery; Epoxy Compounds; Forecasting; Humans; Inflammation; Neoplasms; Phenanthrenes; Tripterygium | 2021 |
Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Diterpenes; Epoxy Compounds; Humans; Immunosuppressive Agents; Inflammation; Phenanthrenes; Psoriasis; Tripterygium | 2012 |
35 other study(ies) available for triptolide and Innate Inflammatory Response
| Article | Year |
|---|---|
Activation of AMPK by triptolide alleviates nonalcoholic fatty liver disease by improving hepatic lipid metabolism, inflammation and fibrosis.
Topics: AMP-Activated Protein Kinases; Animals; Diterpenes; Epoxy Compounds; Inflammation; Lipid Metabolism; Lipids; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Non-alcoholic Fatty Liver Disease; Phenanthrenes | 2021 |
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1.
Topics: Animals; Cytochrome P-450 Enzyme System; Diterpenes; Enzyme Induction; Epoxy Compounds; Inflammation; Liver; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenanthrenes | 2021 |
Triptolide Suppresses NF-κB-Mediated Inflammatory Responses and Activates Expression of Nrf2-Mediated Antioxidant Genes to Alleviate Caerulein-Induced Acute Pancreatitis.
Topics: Acute Disease; Animals; Antioxidants; Ceruletide; China; Disease Models, Animal; Diterpenes; Epoxy Compounds; Gene Expression Regulation; Hep G2 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pancreas; Pancreatitis; Phenanthrenes; Reactive Oxygen Species | 2022 |
Triptolide inhibits oxidative stress and inflammation via the microRNA-155-5p/brain-derived neurotrophic factor to reduce podocyte injury in mice with diabetic nephropathy.
Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Diabetes Mellitus; Diabetic Nephropathies; Diterpenes; Epoxy Compounds; Glucose; Inflammation; Irbesartan; Mice; MicroRNAs; Oxidative Stress; Phenanthrenes; Podocytes | 2022 |
Triptolide Attenuates Muscular Inflammation and Oxidative Stress in a Delayed-Onset Muscle Soreness Animal Model.
Topics: Animals; Carrageenan; Epoxy Compounds; Humans; Inflammation; Models, Animal; Myalgia; Myositis; Oxidative Stress; Phenanthrenes; Rats | 2022 |
pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide.
Topics: Animals; Arthritis, Rheumatoid; Hydrogen-Ion Concentration; Inflammation; Macrophages; Nanoparticles; Polyelectrolytes; Polymers; Rats | 2023 |
Triptolide alleviates collagen-induced arthritis in mice by modulating Treg/Th17 imbalance through the JAK/PTEN-STAT3 pathway.
Topics: Animals; Arthritis, Experimental; Cytokines; Inflammation; Mice; T-Lymphocytes, Regulatory; Th17 Cells | 2023 |
The Effects of Nebulized Inhaled Triptolide on Airway Inflammation in a Mouse Model of Asthma.
Topics: Animals; Asthma; Cytokines; Dexamethasone; Disease Models, Animal; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C | 2023 |
A novel pharmaceutical preparation of Tripterygium wilfordii Hook. f. regulates macrophage polarization to alleviate inflammation in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Inflammation; Interleukin-10; Macrophages; Phosphatidylinositol 3-Kinases; Plant Extracts; Rats; Tripterygium; Tumor Necrosis Factor-alpha | 2023 |
Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest.
Topics: Animals; Behavior, Animal; Brain; Cell Death; Circulatory Arrest, Deep Hypothermia Induced; Diterpenes; Epoxy Compounds; Inflammation; Male; Memory, Short-Term; Microglia; Nerve Growth Factors; Neuroprotective Agents; Oxidative Stress; Phenanthrenes; Rats; Spatial Learning | 2021 |
Triptolide promotes the apoptosis and attenuates the inflammation of fibroblast-like synoviocytes in rheumatoid arthritis by down-regulating lncRNA ENST00000619282.
Topics: Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Diterpenes; Epoxy Compounds; Fibroblasts; Humans; Inflammation; Leukocytes, Mononuclear; Phenanthrenes; RNA, Long Noncoding; Synoviocytes | 2021 |
Triptolide mitigates radiation-induced pneumonitis via inhibition of alveolar macrophages and related inflammatory molecules.
Topics: Antineoplastic Agents, Alkylating; Diterpenes; Epoxy Compounds; Humans; Inflammation; Macrophages, Alveolar; Phenanthrenes; Pneumonia | 2017 |
Triptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Female; Immunosuppressive Agents; Inflammation; Lung; Lung Neoplasms; Male; Mice; NF-kappa B; Phenanthrenes; Phosphorylation; Signal Transduction; Tumor Suppressor Protein p53 | 2017 |
Triptolide exerts protective effects against fibrosis following ileocolonic anastomosis by mechanisms involving the miR-16-1/HSP70 pathway in IL-10-deficient mice.
Topics: Anastomosis, Surgical; Animals; Diterpenes; Epoxy Compounds; Gene Deletion; Gene Expression Regulation; HSP70 Heat-Shock Proteins; Inflammation; Interleukin-10; Intestines; Male; Mice; MicroRNAs; Phenanthrenes; Postoperative Complications; Protective Agents; Signal Transduction | 2017 |
Triptolide inhibits donor-specific antibody production and attenuates mixed antibody-mediated renal allograft injury.
Topics: Allografts; Animals; B-Lymphocytes; Diterpenes; Epoxy Compounds; Graft Rejection; Graft Survival; Immunosuppressive Agents; Inflammation; Isoantibodies; Kidney Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Phenanthrenes; Tissue Donors | 2018 |
Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease.
Topics: Animals; Cell Line; Disease Models, Animal; Diterpenes; Dopaminergic Neurons; Epoxy Compounds; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Male; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Parkinson Disease; Phenanthrenes; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Signal Transduction; Transcriptional Activation; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
Triptolide inhibits the inflammatory activities of neutrophils to ameliorate chronic arthritis.
Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Autophagy; Chronic Disease; Cytokines; Diterpenes; Epoxy Compounds; Extracellular Traps; Inflammation; Leukocyte Elastase; Lipopolysaccharides; Male; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Peroxidase; Phenanthrenes | 2018 |
Complete Freund's adjuvant-induced acute inflammatory pain could be attenuated by triptolide via inhibiting spinal glia activation in rats.
Topics: Acute Pain; Animals; Cytokines; Diterpenes; Drug Evaluation, Preclinical; Enzyme Activation; Epoxy Compounds; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Immunosuppressive Agents; Inflammation; Inflammation Mediators; Male; Neuroglia; Phenanthrenes; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2014 |
TAB1: a target of triptolide in macrophages.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cytokines; Diterpenes; Epoxy Compounds; Inflammation; Lipopolysaccharides; Macrophages; Mice; Phenanthrenes; Protein Binding; Recombinant Proteins; Tripterygium; Tumor Necrosis Factor-alpha | 2014 |
Triptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Brain; Cognition; Disease Models, Animal; Diterpenes; Epoxy Compounds; Habituation, Psychophysiologic; Inflammation; Memory Disorders; Mice; Mice, Transgenic; Phenanthrenes; Presenilin-1; Protein Processing, Post-Translational; Proteolysis; Up-Regulation | 2014 |
Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury.
Topics: Animals; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; I-kappa B Proteins; Inflammation; Motor Activity; Phenanthrenes; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Time Factors | 2015 |
Protective effects of triptolide on TLR4 mediated autoimmune and inflammatory response induced myocardial fibrosis in diabetic cardiomyopathy.
Topics: Animals; Autoimmune Diseases; Blood Glucose; Cardiomyopathies; Diabetic Cardiomyopathies; Diterpenes; Epoxy Compounds; Fibrosis; Heart Function Tests; Immunity, Innate; Inflammation; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 4 | 2016 |
Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Diterpenes; Down-Regulation; Epoxy Compounds; Glomerulonephritis, Membranous; Inflammation; Male; NF-kappa B; Phenanthrenes; Rats; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia.
Topics: Animals; Blotting, Western; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Diterpenes; Electrophoretic Mobility Shift Assay; Epoxy Compounds; Immunosuppressive Agents; Inflammation; Lipopolysaccharides; MAP Kinase Kinase 4; Microglia; NF-kappa B; Phenanthrenes; Rats; Rats, Sprague-Dawley; Signal Transduction; Transfection | 2008 |
Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Disease Models, Animal; Diterpenes; Epoxy Compounds; Exploratory Behavior; Glial Fibrillary Acidic Protein; Gliosis; Immunosuppressive Agents; Inflammation; Janus Kinase 2; Male; Neurofilament Proteins; Phenanthrenes; Psychomotor Performance; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries; STAT3 Transcription Factor | 2010 |
Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Diterpenes; Enzyme Inhibitors; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases; Humans; Inflammation; Leukemia; Molecular Structure; Neoplasm Invasiveness; Neoplasm Metastasis; NF-kappa B; Paclitaxel; Phenanthrenes; Signal Transduction; Thalidomide; Tumor Necrosis Factor-alpha | 2011 |
Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cell Line; Cytokines; Diterpenes; Epoxy Compounds; Gelatin; Hydrogels; Inflammation; Male; Mice; Micelles; Phenanthrenes; Rats; Rats, Wistar | 2012 |
MKP-1: a negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Diterpenes; Dual Specificity Phosphatase 1; Epoxy Compounds; Feedback, Physiological; Gene Expression Regulation; Histones; Humans; Imidazoles; Inflammation; Interleukin-8; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Primary Cell Culture; Promoter Regions, Genetic; Pyridines; Ribosomal Protein S6 Kinases, 90-kDa; RNA Stability; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha | 2012 |
Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Carbonates; Cell Line; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Inflammation; Lactones; Male; Mice; Pentacyclic Triterpenes; Phenanthrenes; Phytotherapy; Pyridines; Rats; Tripterygium; Triterpenes | 2012 |
Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Count; Cells, Cultured; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Female; Immunohistochemistry; Inflammation; Lipopolysaccharides; Male; Mesencephalon; Microglia; Neurons; Nitrites; Phenanthrenes; Pregnancy; Rats; Tritium; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2004 |
The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Cycle Proteins; Cell Line; Diterpenes; Dual Specificity Phosphatase 1; Enzyme Activation; Epoxy Compounds; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression; Immediate-Early Proteins; Inflammation; Interleukin-1; JNK Mitogen-Activated Protein Kinases; Macrophages; Macrophages, Peritoneal; MAP Kinase Kinase 4; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; p38 Mitogen-Activated Protein Kinases; Peptidoglycan; Phenanthrenes; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Transfection; Tumor Necrosis Factor-alpha | 2004 |
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes.
Topics: ADAM Proteins; ADAMTS4 Protein; Animals; Cartilage; Cattle; Cells, Cultured; Chondrocytes; Collagenases; Cytokines; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Epoxy Compounds; Gene Expression Regulation; Humans; Inflammation; Interleukin-1; Interleukin-17; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Phenanthrenes; Plant Extracts; Procollagen N-Endopeptidase; RNA, Messenger; Tripterygium; Tumor Necrosis Factor-alpha | 2005 |
Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice.
Topics: Animals; Arthritis, Experimental; Cartilage; Collagen; Cytokines; Dinoprostone; Disease Progression; Diterpenes; Epoxy Compounds; Gene Expression; Immunohistochemistry; In Situ Hybridization; Inflammation; Male; Mice; Mice, Inbred DBA; NF-kappa B; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.
Topics: Animals; Blotting, Western; Cell Proliferation; Cytokines; Demyelinating Diseases; Diterpenes; Electrophoretic Mobility Shift Assay; Encephalomyelitis, Autoimmune, Experimental; Epoxy Compounds; Forkhead Transcription Factors; Gene Expression; Immunosuppressive Agents; Inflammation; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; T-Lymphocytes | 2008 |
PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Survival; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Fibroblasts; Immunosuppressive Agents; Inflammation; Lung; Male; Mice; Mice, Inbred C57BL; Phenanthrenes; Pulmonary Fibrosis; Transcription, Genetic; Transforming Growth Factor beta | 2001 |