triptolide has been researched along with Granulocytic Leukemia, Chronic in 5 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, J; Jin, Y; Li, S; Lin, Y; Lu, Z; Pan, J; Pang, J; Shi, X; Xu, F | 1 |
| Chen, Q; Cheng, C; Jin, Y; Lai, Y; Lu, Z; Pan, J; Shi, X; Zhang, H; Zheng, Q; Zou, W | 1 |
| Andreeff, M; Carter, BZ; Chen, W; Cortes, J; Kantarjian, HM; Konopleva, M; Mak, DH; Schober, WD | 1 |
| Andreeff, M; Carter, BZ; Cortes, J; Kantarjian, H; Konopleva, M; Mak, DH; Schober, WD; Wang, RY | 1 |
| Jin, J; Lou, YJ | 1 |
5 other study(ies) available for triptolide and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Apoptosis; Benzamides; Binding Sites; Cell Line; Computer Simulation; Diterpenes; Down-Regulation; Drug Design; Drug Resistance, Neoplasm; Epoxy Compounds; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Nude; Phenanthrenes; Piperazines; Pyrimidines; RNA, Messenger; Signal Transduction; Water; Xenograft Model Antitumor Assays | 2010 |
Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.
Topics: Adolescent; Adult; Aged; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Blotting, Western; Cell Cycle; Cell Proliferation; Diterpenes; Drug Resistance, Neoplasm; Epoxy Compounds; Female; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoenzyme Techniques; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Phenanthrenes; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Tripterygium; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays; Young Adult | 2009 |
Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.
Topics: Antigens, CD34; Antineoplastic Agents, Alkylating; Apoptosis; Benzamides; Blast Crisis; Blotting, Western; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phenanthrenes; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.
Topics: Antigens, CD34; Apoptosis; Benzamides; Biphenyl Compounds; Blast Crisis; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nitrophenols; Phenanthrenes; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; RNA, Messenger; Signal Transduction; Sulfonamides | 2012 |
Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells.
Topics: Annexin A5; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor; Diterpenes; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epoxy Compounds; Fusion Proteins, bcr-abl; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Translocation, Genetic | 2004 |