triptolide has been researched along with Disease Models, Animal in 81 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (12.35) | 29.6817 |
| 2010's | 56 (69.14) | 24.3611 |
| 2020's | 15 (18.52) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Cheng, L; Gong, Y; Huang, C; Jin, C; Lai, K; Li, C; Li, L; Li, Y; Xu, F; Zhang, Y; Zhao, H; Zhong, X | 1 |
| Lin, H; Peng, Z; Qin, X; Zhang, C; Zhang, X; Zheng, H | 1 |
| Dai, Y; Ke, X; Shi, J; Tang, X; Yang, J | 1 |
| Li, M; Ma, GC; Ma, ZJ; Rao, Q; Wang, D; Wang, GJ; Wu, H; Xu, W; Zhang, CE; Zhang, ZT | 1 |
| Huang, L; Li, M; Ma, G; Ma, Z; Rao, Q; Wu, H; Zhang, C; Zhang, Y | 1 |
| Mao, R; Sun, G; Wang, Y; Xu, S; Yang, K; Yang, W; Yu, Y; Zhang, Z; Zuo, Z | 1 |
| Jin, Z; Ma, X; Ni, R; Pan, Y; Wu, Q; Yang, G | 1 |
| Chen, H; Han, L; Miao, Y; Wei, L; Zhang, Z | 1 |
| Chen, H; Du, Y; Fu, W; Huang, S; Huang, Z; Liang, T; Qian, B; Shi, H; Tan, P; Wang, A | 1 |
| Cui, Q; Liu, XC; Ma, D; Wang, XX; Yang, F; Zhang, J; Zheng, H | 1 |
| Feng, Z; Fu, L; Geng, S; Li, M; Lu, W; Lu, Y; Zhou, L; Zhou, X | 1 |
| Huang, X; Jiang, Z; Li, H; Li, L; Sun, L; Wang, T; Wang, X; Xing, X; Zhang, L; Zhang, X | 1 |
| Gao, Y; Wang, Y; Xie, S; Zhang, J; Zhang, S; Zhu, M | 1 |
| Chen, M; Fang, S; Ji, J; Qiu, R; Tang, B; Wang, Y; Weng, Q; Wu, F; Xu, M; Yang, Y; Zhang, B; Zhao, Z; Zheng, L; Zhu, J | 1 |
| Cheng, Y; He, T; Li, S; Li, X; Liu, B; Qian, H; Shen, F; Wu, Y; Yang, G; Yang, H; Zheng, X | 1 |
| Anandharaj, A; Cornax, I; Kassie, F; Kirtane, AR; Molla, K; O Sullivan, MG; Panyam, J; Song, JM | 1 |
| Chen, XF; Li, YF; Zhang, W; Zou, YF | 1 |
| Chen, G; Chen, J; Cheng, X; Du, P; Hu, Q; Hua, ZC; Jiang, W; Liu, X; Qiao, Y; Tang, B; Wei, J; Yang, B; Zhang, X | 1 |
| Berends, C; Buckley, C; de Potter, CMJ; Dear, JW; Del Pozo, J; Mullins, JJ; Schneemann, S; Tucker, C; Vliegenthart, ADB; Webb, DJ; Wei, C | 1 |
| Chen, JN; Dou, YX; Huang, QH; Huang, YF; Li, YX; Su, ZR; Wang, L; Xie, JH; Xu, LQ; Zeng, HF | 1 |
| Chen, H; Chen, Q; Fu, Z; Jiang, CM; Li, ZY; Li, ZZ; Liu, L; Shi, GY; Su, YM; Sui, BW; Sun, HQ; Yang, LZ; Zhang, W; Zhao, WC | 1 |
| Cai, J; Li, C; Wang, G; Zhang, J | 1 |
| Feng, Z; Liu, Z; Zhou, C; Zhou, L; Zhou, X; Zhu, H | 1 |
| Chen, D; Fu, L; Gu, J; He, L; Jing, Y; Li, L; Mei, C; Mei, S; Qi, N; Wu, M; Yang, M; Zhang, D | 1 |
| Chen, Z; Li, SG; Ling, CQ; Miao, YQ; Qin, LP; Qin, WX; Shi, QW; Wang, Y; Yuan, LY | 1 |
| Gu, L; Huang, YY; Wang, XM; Xia, N; Yang, HM; Zhang, H; Zhang, JN; Zhang, Q; Zhang, YN | 1 |
| Qian, K; Shi, K; Zhang, L | 1 |
| Ji, X; Liu, Z; Wang, S; Wang, X; Yao, Z; Zuo, S | 1 |
| Gu, Y; Liu, J; Tang, X; Yang, D; Yang, M | 1 |
| Chen, T; Ren, Y; Tang, X; Tian, P; Wang, H; Wang, Y; Xin, H; Zhao, X | 1 |
| Chen, H; Li, Z; Song, H; Sun, L; Tang, X; Wang, D; Yan, Q; Zhao, X | 1 |
| Banerjee, S; Dudeja, V; Giri, B; Gupta, VK; Lavania, SP; Modi, S; Roy, P; Saluja, A; Sethi, V; Vickers, SM; Watts, J; Yaffe, B | 1 |
| Liang, ZS; Wen, HL; Yang, K; Zhang, R | 1 |
| Hu, X; Li, Y; Lü, C; Nie, J; Wan, B; Wen, W; Yang, B; Zhou, M | 1 |
| Guo, X; Li, Y; Wang, D; Wu, L; Yang, F | 1 |
| Chen, G; He, X; Li, J; Liu, B; Lu, A; Lu, C; Zhang, G; Zhang, H | 1 |
| Chen, YS; Chen, ZP; Guan, S; Guo, CC; Li, WP; Li, WY; Mou, YG; Sai, K; Wang, J; Yang, QY | 1 |
| Li, G; Liu, Y; Xiao, E; Yuan, L | 1 |
| Ding, Y; Duan, W; Gong, P; Liu, B; Wang, X; Wu, X; Zhang, L | 1 |
| Chen, YF; Chen, Z; Hang, LH; Li, SN; Shao, DH; Shu, WW | 1 |
| Cheng, S; LeBlanc, KJ; Li, L | 1 |
| Al-Assaad, AS; Angagaw, MH; Ayers, M; Blanchard, R; Booher, RN; Dolinski, BM; Fawell, SE; Gilliland, G; Harmonay, L; Hatch, H; Hirsch, HA; Im, EK; Kondic, AG; Lee, J; Lennon, XQ; Loboda, A; Long, BJ; Mauro, D; Merkel, CE; Miselis, N; Monahan, JW; Nebozhyn, M; Nguyen, T; Pucci, V; Schuller, AG; Shi, B; Strack, P; Wang, Y; Zawel, L; Zhang, T | 1 |
| Chen, M; Huang, L; Jiang, S; Liang, R; Lin, X; Lv, Z; Shi, J; Zhang, W | 1 |
| An, H; Cui, S; Cui, Y; Dong, L; Gong, X; He, Y; Hu, G; Qian, Y; Song, H; Wang, Q; Wang, X; Xiao, B; Yan, Z; Yang, J; Zhang, F; Zhang, J; Zhang, W; Zheng, Y | 1 |
| Geng, Q; Jiang, W; Liang, Q; Tang, W; Xu, X; Zhang, J | 1 |
| Chen, C; Song, RX; Wang, B; Yu, XC; Zhang, JT | 1 |
| Chen, WL; Chen, XY; Gu, C; Li, B; Ma, M; Xiao, XR | 1 |
| Gao, Y; Qi, G; Shi, L; Sun, Y; Yu, H; Zhao, S | 1 |
| He, L; Liu, F; Liu, G; Liu, H; Peng, X; Peng, Y; Tang, C; Zhou, H | 1 |
| Bai, S; Fang, M; Hu, Z; Li, W; Wu, L; Yang, Y; Yin, Y | 1 |
| Li, Y; Wang, D; Wu, L; Yang, F | 1 |
| Chang, B; Chen, L; Guo, H; Guo, J; Liu, H; Pan, C; Wu, X; Zhou, Y; Zhu, Z | 1 |
| An, G; Feng, G; Guo, Y; Liang, X; Song, H; Wang, M; Xing, E; Zhao, X | 1 |
| Hong, Y; Huang, H; Zhou, Y | 1 |
| Gao, S; Li, K; Liu, G; Wang, L; Wu, X; Zhang, Y | 1 |
| An, ZM; Dong, XG; Guo, Y; Qin, T; Zhou, JL | 1 |
| Dong, Y; Hu, X; Jin, X; Li, J; Shi, J; Zhang, C; Zhang, T; Zhao, J | 1 |
| Fan, F; Gao, CY; Hoffmann, V; Lipsky, PE; Longo, NS; Tao, X; Zerfas, P | 1 |
| Gong, J; Li, J; Li, N; Niu, L; Wei, X; Zhu, J; Zhu, W | 1 |
| But, PP; Ge, W; He, MF; Jiang, R; Liu, L; Shaw, PC; Wu, LW | 1 |
| Chen, YW; Chia, WT; Chuang, YP; Lin, CK; Lin, GJ; Sytwu, HK | 1 |
| Kizelsztein, P; Komarnytsky, S; Raskin, I | 1 |
| Chen, JG; Gao, TW; Liu, YF | 1 |
| Bencivenga, N; Chahboune, H; Crews, CM; Hyder, F; Leuenroth, SJ | 1 |
| Cao, L; Gao, L; He, C; Qiu, Y; Su, Z; Yuan, Y; Zhu, Y | 1 |
| Chen, ZH; Hong, YM; Li, LS; Liu, ZH; Lu, YZ; Qin, WS; Zeng, CH; Zheng, CX | 1 |
| Cui, SH; Li, F; Liu, S; Luo, B; Sun, HC; Sun, JB; Xin, MJ | 1 |
| Guo, AY; Guo, XM; Yan, SZ | 1 |
| Chen, M; Jiang, S; Lv, Z | 1 |
| Jia, D | 1 |
| Lu, L; Wang, P; Wu, C; Xia, Y; Zhang, F | 1 |
| An, LM; Hsu, YY; Jong, YJ; Lo, YC; Tsai, HH; Tseng, YT | 1 |
| Kou, YR; Lee, HF; Lee, TS | 1 |
| Csaderova, L; Giubellino, A; Hudecova, S; Krizanova, O; Laukova, M; Lencesova, L; Pacak, K; Sirova, M | 1 |
| Hu, X; Li, Y; Lü, C; Nie, J; Wan, B; Yang, B; Zhou, M | 1 |
| DeLeo, JA; Landry, RP; Martinez, E; Romero-Sandoval, EA | 1 |
| Li, X; Li, Y; Sun, B; Wang, Y; Wu, Y; Zhong, C | 1 |
| Chen, XP; Zhai, WL; Zhang, SJ; Zhao, YF | 1 |
| Cui, D; Gondo, T; Hoshii, Y; Ishihara, T; Kawano, H; Liu, Y; Sugiyama, S | 1 |
| Benson, GV; Berry, GJ; Faul, JL; Kao, PN; Nishimura, T; Pearl, RG | 1 |
81 other study(ies) available for triptolide and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Intravitreal injection of triptolide attenuates subretinal fibrosis in laser-induced murine model.
Topics: Aged; Animals; Disease Models, Animal; Diterpenes; Epithelial-Mesenchymal Transition; Epoxy Compounds; Fibrosis; Humans; Intravitreal Injections; Lasers; Mice; Mice, Inbred C57BL; Phenanthrenes; Transforming Growth Factor beta1 | 2021 |
The Potential Protective Effect and Possible Mechanism of Peptides from Oyster (
Topics: Animals; Aquatic Organisms; Crassostrea; Disease Models, Animal; Diterpenes; Epoxy Compounds; Male; Mice; Mice, Inbred ICR; Peptides; Phenanthrenes; Protective Agents; Spermatogenesis; Testis | 2021 |
Triptolide Suppresses NF-κB-Mediated Inflammatory Responses and Activates Expression of Nrf2-Mediated Antioxidant Genes to Alleviate Caerulein-Induced Acute Pancreatitis.
Topics: Acute Disease; Animals; Antioxidants; Ceruletide; China; Disease Models, Animal; Diterpenes; Epoxy Compounds; Gene Expression Regulation; Hep G2 Cells; Humans; Inflammation; Male; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Pancreas; Pancreatitis; Phenanthrenes; Reactive Oxygen Species | 2022 |
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models.
Topics: Animals; Colitis; Dendritic Cells; Disease Models, Animal; Diterpenes; Epoxy Compounds; Mice; Mice, Inbred C57BL; Phenanthrenes | 2022 |
Targeted delivery of triptolide by dendritic cell-derived exosomes for colitis and rheumatoid arthritis therapy in murine models.
Topics: Animals; Arthritis, Rheumatoid; Colitis; Dendritic Cells; Disease Models, Animal; Exosomes; Mice | 2023 |
Triptolide injection reduces Alzheimer's disease-like pathology in mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytokines; Disease Models, Animal; Diterpenes; Hippocampus; Male; Mice; Mice, Inbred C57BL | 2023 |
Zhuidu Formula suppresses the migratory and invasive properties of triple-negative breast cancer cells via dual signaling pathways of RhoA/ROCK and CDC42/MRCK.
Topics: Actins; Animals; Cell Adhesion; Cell Growth Processes; Cell Movement; Cytoskeleton; Disease Models, Animal; Drug Synergism; Ethnopharmacology; Female; Humans; Matrix Metalloproteinases; MDA-MB-231 Cells; Medicine, Chinese Traditional; Mice; Myotonin-Protein Kinase; Neoplasm Invasiveness; Neoplasm Metastasis; Paclitaxel; rho-Associated Kinases; Signal Transduction; Triple Negative Breast Neoplasms | 2023 |
The Effects of Nebulized Inhaled Triptolide on Airway Inflammation in a Mouse Model of Asthma.
Topics: Animals; Asthma; Cytokines; Dexamethasone; Disease Models, Animal; Inflammation; Interleukin-17; Mice; Mice, Inbred BALB C | 2023 |
Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-κB (p65)/IL-6 signalling pathway.
Topics: Animals; Cells, Cultured; Ceruletide; Cytoskeletal Proteins; Disease Models, Animal; Diterpenes; DNA-Binding Proteins; Down-Regulation; Epoxy Compounds; Fibrosis; Interleukin-6; LIM Domain Proteins; Mice, Knockout; NF-kappa B; Pancreas; Pancreatic Stellate Cells; Pancreatitis, Chronic; Phenanthrenes; Signal Transduction; Transcription Factor RelA; Transforming Growth Factor beta | 2020 |
Effects Of Triptolide On Tooth Movement And Root Resorption In Rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Diterpenes; Epoxy Compounds; Male; Orthodontic Appliances, Removable; Phenanthrenes; Rats; Rats, Wistar; Root Resorption; Tooth Movement Techniques | 2019 |
Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Glucuronosyltransferase; Hep G2 Cells; Hepatocytes; Humans; Iridoid Glucosides; Liver; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; NF-E2-Related Factor 2; Phenanthrenes; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2020 |
Effects of triptolide on the sphingosine kinase - Sphingosine-1-phosphate signaling pathway in colitis-associated colon cancer.
Topics: Animals; Azoxymethane; Colitis; Colitis-Associated Neoplasms; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Humans; Lysophospholipids; Male; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Phenanthrenes; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sphingosine; THP-1 Cells; Tumor-Associated Macrophages | 2020 |
Triptolide attenuates renal damage by limiting inflammatory responses in DOCA-salt hypertension.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion Molecules; Cytokines; Desoxycorticosterone Acetate; Disease Models, Animal; Diterpenes; Epoxy Compounds; Hypertension; Inflammation Mediators; Kidney; Kidney Diseases; Male; Mice, Inbred C57BL; Nephrectomy; NF-kappa B; Phenanthrenes; Signal Transduction; Sodium Chloride, Dietary | 2020 |
Therapeutic Potential of Triptolide as an Anti-Inflammatory Agent in Dextran Sulfate Sodium-Induced Murine Experimental Colitis.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Colitis; Computational Biology; Cytokines; Dextran Sulfate; Disease Models, Animal; Diterpenes; Epoxy Compounds; Gene Expression Profiling; Inflammation Mediators; Inflammatory Bowel Diseases; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Models, Biological; Phenanthrenes; RAW 264.7 Cells; Reactive Oxygen Species; Signal Transduction | 2020 |
Triptolide dose-dependently improves LPS-induced alveolar hypercoagulation and fibrinolysis inhibition through NF-κB inactivation in ARDS mice.
Topics: Animals; Disease Models, Animal; Diterpenes; Epoxy Compounds; Fibrinolysis; Lipopolysaccharides; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Phenanthrenes; Respiratory Distress Syndrome; Signal Transduction; Thrombophilia; Thromboplastin | 2021 |
Triptolide suppresses the in vitro and in vivo growth of lung cancer cells by targeting hyaluronan-CD44/RHAMM signaling.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Disease Models, Animal; Diterpenes; Epoxy Compounds; Extracellular Matrix Proteins; Gene Silencing; Humans; Hyaluronan Receptors; Hyaluronan Synthases; Lung Neoplasms; Male; Phenanthrenes; Rats; RNA, Small Interfering; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
Effect of Triptolide on retinal ganglion cell survival in an optic nerve crush model.
Topics: Animals; Axons; Cell Nucleus; Cell Survival; Disease Models, Animal; Diterpenes; Epoxy Compounds; Mice, Inbred C57BL; Nerve Crush; Nerve Regeneration; Optic Nerve Injuries; Phenanthrenes; Protein Transport; Retinal Ganglion Cells; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2017 |
Modulation of
Topics: Animals; Biological Therapy; Combined Modality Therapy; Disease Models, Animal; Diterpenes; Epoxy Compounds; Immunosuppressive Agents; Melanoma; Mice, Inbred C57BL; Necrosis; Neovascularization, Pathologic; Neutrophils; Phenanthrenes; Salmonella; Treatment Outcome; Vascular Endothelial Growth Factor A | 2017 |
Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Diterpenes; Epoxy Compounds; Larva; Liver; MicroRNAs; Microscopy, Fluorescence; Phenanthrenes; Polymerase Chain Reaction; Sequence Analysis, RNA; Transcriptome; Zebrafish | 2017 |
Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Diterpenes; Epoxy Compounds; Hepatocytes; Inflammation Mediators; Lipid Peroxidation; Male; Oxidative Stress; Phenanthrenes; Protective Agents; Rats; Reactive Oxygen Species; Silymarin | 2018 |
Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition.
Topics: Animals; Cell Line; Cell Movement; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxy Compounds; Humans; Idiopathic Pulmonary Fibrosis; Lung; Mice; Molecular Docking Simulation; Paraquat; Phenanthrenes; Protein Binding; Transforming Growth Factor beta1 | 2018 |
Mechanism of triptolide in treating ankylosing spondylitis through the anti‑ossification effect of the BMP/Smad signaling pathway.
Topics: Animals; Biomarkers; Bone Morphogenetic Proteins; Cell Proliferation; Cytokines; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Fibroblasts; Gene Expression; Immunosuppressive Agents; Male; Osteogenesis; Phenanthrenes; Protein Isoforms; Rats; RNA, Messenger; Signal Transduction; Smad Proteins; Spondylitis, Ankylosing | 2018 |
Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Cell Line; Chemical and Drug Induced Liver Injury; Cytochromes c; Cytoprotection; Disease Models, Animal; Diterpenes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Liver; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Proteins; NF-E2-Related Factor 1; Panax; Phenanthrenes; Phytotherapy; Plants, Medicinal; Quaternary Ammonium Compounds; Rats, Sprague-Dawley; Saponins; Transcription Factors | 2018 |
Triptolide delays disease progression in an adult rat model of polycystic kidney disease through the JAK2-STAT3 pathway.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Cell Line; Cell Proliferation; Creatinine; Disease Models, Animal; Disease Progression; Diterpenes; Epoxy Compounds; Humans; Interleukin-6; Janus Kinase 2; Kidney; Male; Phenanthrenes; Phosphorylation; Polycystic Kidney Diseases; Proteinuria; Rats, Transgenic; Receptors, Interleukin-6; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein | 2018 |
C-Myc-dependent repression of two oncogenic miRNA clusters contributes to triptolide-induced cell death in hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Carcinoma, Hepatocellular; Cell Death; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Diterpenes; DNA Helicases; DNA-Binding Proteins; Epoxy Compounds; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mice; MicroRNAs; Oncogenes; Phenanthrenes; Proto-Oncogene Proteins c-myc; RNA Interference; Xenograft Model Antitumor Assays | 2018 |
Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease.
Topics: Animals; Cell Line; Disease Models, Animal; Diterpenes; Dopaminergic Neurons; Epoxy Compounds; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophage Activation; Male; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Parkinson Disease; Phenanthrenes; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Signal Transduction; Transcriptional Activation; Tumor Necrosis Factor-alpha; Up-Regulation | 2018 |
Triptolide prevents osteoarthritis via inhibiting hsa-miR-20b.
Topics: Animals; Cell Line; Cytokines; Disease Models, Animal; Diterpenes; Down-Regulation; Epoxy Compounds; Humans; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Monocytes; NLR Family, Pyrin Domain-Containing 3 Protein; Osteoarthritis; Phenanthrenes; THP-1 Cells; Up-Regulation | 2019 |
Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Biomarkers; Bone Resorption; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Inflammation Mediators; Joints; Lymphocytes; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Osteoclasts; Phenanthrenes; Risk Assessment; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Transdermal drug delivery of triptolide-loaded nanostructured lipid carriers: Preparation, pharmacokinetic, and evaluation for rheumatoid arthritis.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Delayed-Action Preparations; Disease Models, Animal; Diterpenes; Drug Carriers; Drug Delivery Systems; Drug Liberation; Edema; Epoxy Compounds; Immunosuppressive Agents; Lipids; Male; Microdialysis; Nanostructures; Particle Size; Phenanthrenes; Rats; Rats, Sprague-Dawley; Skin Absorption | 2019 |
Triptolide modulates tumour-colonisation and anti-tumour effect of attenuated Salmonella encoding DNase I.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Deoxyribonuclease I; Disease Models, Animal; Diterpenes; Drug Carriers; Epoxy Compounds; Genetic Vectors; Humans; Melanoma; Mice; Models, Biological; Phenanthrenes; Plasmids; Salmonella; Salmonella Infections; Treatment Outcome; Vaccines, DNA | 2019 |
Triptolide ameliorates lupus via the induction of miR-125a-5p mediating Treg upregulation.
Topics: Animals; Antibodies, Antinuclear; Antirheumatic Agents; Cell Proliferation; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Humans; Kidney; Lupus Erythematosus, Systemic; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; MicroRNAs; Phenanthrenes; Proteinuria; T-Lymphocytes, Regulatory; Up-Regulation | 2019 |
Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Diterpenes; Down-Regulation; Drug Evaluation, Preclinical; Epoxy Compounds; Humans; Leukemia, Myeloid, Acute; Mice; Neoplastic Stem Cells; Organophosphates; Phenanthrenes; Proto-Oncogene Proteins c-myc; Tumor Burden; Tumor Stem Cell Assay | 2019 |
Anti-inflammatory effects of triptolide improve left ventricular function in a rat model of diabetic cardiomyopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; Diterpenes; Epoxy Compounds; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Ventricular Function, Left | 2013 |
Effects of triptolide on degeneration of dendritic spines induced by Aβ1-40 injection in rat hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Dendritic Spines; Disease Models, Animal; Diterpenes; Epoxy Compounds; Hippocampus; Immunosuppressive Agents; Male; Nerve Degeneration; Peptide Fragments; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2014 |
Improved retinal ganglion cell survival through retinal microglia suppression by a chinese herb extract, triptolide, in the DBA/2J mouse model of glaucoma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Follow-Up Studies; Glaucoma; Immunohistochemistry; Immunosuppressive Agents; Intraocular Pressure; Mice; Mice, Inbred DBA; Microglia; Phenanthrenes; Receptors, Tumor Necrosis Factor, Type I; Retinal Ganglion Cells; Treatment Outcome | 2013 |
Triptolide downregulates Treg cells and the level of IL-10, TGF-β, and VEGF in melanoma-bearing mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Diterpenes; Down-Regulation; Drugs, Chinese Herbal; Epoxy Compounds; Forkhead Transcription Factors; Interleukin-10; Lymph Nodes; Male; Melanoma; Mice, Inbred C57BL; Phenanthrenes; Phytotherapy; RNA, Messenger; Spleen; T-Lymphocytes, Regulatory; Transforming Growth Factor beta; Tripterygium; Vascular Endothelial Growth Factor A | 2013 |
Triptolide synergistically enhances temozolomide-induced apoptosis and potentiates inhibition of NF-κB signaling in glioma initiating cells.
Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Dacarbazine; Disease Models, Animal; Diterpenes; Drug Synergism; Epoxy Compounds; Glioma; Humans; Mice; Neoplasm Transplantation; NF-kappa B; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Stimulation, Chemical; Temozolomide; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2014 |
Triptolide synergistically enhances antitumor activity of oxaliplatin in colon carcinoma in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; beta Catenin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Diterpenes; Drug Synergism; Epoxy Compounds; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Molecular Structure; Organoplatinum Compounds; Oxaliplatin; Phenanthrenes; Protein Transport | 2014 |
Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Chemokines; Disease Models, Animal; Diterpenes; Epoxy Compounds; I-kappa B Proteins; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Phenanthrenes; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha | 2014 |
Evidence for involvement of spinal RANTES in the antinociceptive effects of triptolide, a diterpene triepoxide, in a rat model of bone cancer pain.
Topics: Analgesics; Animals; Blotting, Western; Bone Neoplasms; Carcinoma 256, Walker; Chemokine CCL5; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Neoplasm Transplantation; Pain; Pain Measurement; Phenanthrenes; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Spinal Cord | 2014 |
Triptolide preserves cognitive function and reduces neuropathology in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Anxiety; Brain; Cognition; Disease Models, Animal; Diterpenes; Epoxy Compounds; Habituation, Psychophysiologic; Inflammation; Memory Disorders; Mice; Mice, Transgenic; Phenanthrenes; Presenilin-1; Protein Processing, Post-Translational; Proteolysis; Up-Regulation | 2014 |
MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle Checkpoints; Cell Line, Tumor; Cyclic N-Oxides; Disease Models, Animal; Diterpenes; Drug Resistance, Neoplasm; Drug Synergism; Epoxy Compounds; Female; Gene Dosage; Humans; Indolizines; Male; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Phenanthrenes; Pyridinium Compounds; RNA, Messenger; Sulfonamides; Xenograft Model Antitumor Assays | 2014 |
Triptolide suppresses airway goblet cell hyperplasia and Muc5ac expression via NF-κB in a murine model of asthma.
Topics: Airway Remodeling; Animals; Asthma; Blotting, Western; Bronchi; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Goblet Cells; Hyperplasia; Hypertrophy; Mice, Inbred BALB C; Mucin 5AC; Mucus; NF-kappa B; Phenanthrenes; Phosphorylation; RNA, Messenger; Transcription Factor RelA | 2015 |
Triptolide treatment reduces Alzheimer's disease (AD)-like pathology through inhibition of BACE1 in a transgenic mouse model of AD.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartic Acid Endopeptidases; Brain; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Humans; Immunosuppressive Agents; Learning; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phenanthrenes; Plant Extracts | 2014 |
Triptolide attenuates acute small-for-size liver graft injury in rats by inhibition of Toll-like receptor 4.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Disease Models, Animal; Diterpenes; Epoxy Compounds; Gene Expression Regulation; Graft Rejection; Immunosuppressive Agents; Liver; Liver Transplantation; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Toll-Like Receptor 4 | 2014 |
Triptolide (TPL) improves locomotor function recovery in rats and reduces inflammation after spinal cord injury.
Topics: Animals; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; I-kappa B Proteins; Inflammation; Motor Activity; Phenanthrenes; Rats; Rats, Sprague-Dawley; Recovery of Function; Spinal Cord Injuries; Time Factors | 2015 |
The potential of follicle-stimulating hormone peptide-modified triptolide-loaded nanoparticles to induce a mouse model of premature ovarian insufficiency.
Topics: Animals; Apoptosis; Disease Models, Animal; Diterpenes; Drug Delivery Systems; Epoxy Compounds; Female; Fertility; Follicle Stimulating Hormone; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Nanoparticles; Phenanthrenes; Primary Ovarian Insufficiency | 2015 |
Triptolide Attenuates Myocardial Ischemia/Reperfusion Injuries in Rats by Inducing the Activation of Nrf2/HO-1 Defense Pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cardiotonic Agents; Cytokines; Cytoprotection; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoxy Compounds; Heme Oxygenase (Decyclizing); Inflammation Mediators; Macrophages; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NF-E2-Related Factor 2; Oxidative Stress; Phenanthrenes; Rats, Wistar; Signal Transduction; Ventricular Function, Left | 2016 |
Anti-inflammatory effects of triptolide on IgA nephropathy in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrier Proteins; Disease Models, Animal; Diterpenes; Epoxy Compounds; Gene Expression Regulation; Glomerulonephritis, IGA; Interleukin-18; Interleukin-1beta; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Phenanthrenes; Rats; Rats, Sprague-Dawley; Toll-Like Receptor 4 | 2015 |
Anti-Inflammatory and Neuroprotective Effects of Triptolide via the NF-κB Signaling Pathway in a Rat MCAO Model.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Apoptosis; Blotting, Western; Cyclooxygenase 2; Disease Models, Animal; Diterpenes; Epoxy Compounds; Glial Fibrillary Acidic Protein; Immunoenzyme Techniques; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Phenanthrenes; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Signal Transduction | 2016 |
Protective effects of triptolide on retinal ganglion cells in a rat model of chronic glaucoma.
Topics: Animals; Cell Survival; Disease Models, Animal; Diterpenes; Epoxy Compounds; Glaucoma; Injections, Intraperitoneal; Intraocular Pressure; Microglia; Phenanthrenes; Rats; Rats, Wistar; Retinal Ganglion Cells; Tumor Necrosis Factor-alpha | 2015 |
Triptolide Improves Diabetic Nephropathy by Regulating Th Cell Balance and Macrophage Infiltration in Rat Models of Diabetic Nephropathy.
Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Diterpenes; Epoxy Compounds; Immunosuppressive Agents; Macrophages; Male; Phenanthrenes; Rats; Rats, Sprague-Dawley; Th1 Cells; Th2 Cells | 2016 |
Therapeutic effect of dioscin on collagen-induced arthritis through reduction of Th1/Th2.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen Type II; Dioscorea; Diosgenin; Disease Models, Animal; Diterpenes; Epoxy Compounds; GATA3 Transcription Factor; Humans; Male; Mice; Mice, Inbred DBA; Phenanthrenes; STAT Transcription Factors; Synovial Membrane; Th1 Cells; Th1-Th2 Balance; Th2 Cells | 2016 |
Triptolide Attenuates Inflammatory Response in Membranous Glomerulo-Nephritis Rat via Downregulation of NF-κB Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Diterpenes; Down-Regulation; Epoxy Compounds; Glomerulonephritis, Membranous; Inflammation; Male; NF-kappa B; Phenanthrenes; Rats; Rats, Sprague-Dawley; Signal Transduction | 2016 |
Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dextran Sulfate; Disease Models, Animal; Diterpenes; Epoxy Compounds; Humans; Ileum; Intestinal Mucosa; Male; Occludin; Phenanthrenes; Pouchitis; Rats; Rats, Sprague-Dawley; Tripterygium; Zonula Occludens-1 Protein | 2017 |
Effect of triptolide on expression of oxidative carbonyl protein in renal cortex of rats with diabetic nephropathy.
Topics: Animals; Blood Glucose; Diabetic Nephropathies; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Gene Expression Regulation; Humans; Kidney Cortex; Oxidative Stress; Phenanthrenes; Protein Carbonylation; Proteins; Random Allocation; Rats; Rats, Sprague-Dawley; Streptozocin; Superoxide Dismutase | 2017 |
The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Chronic Pain; Depression; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug Therapy, Combination; Encephalitis; Epoxy Compounds; Fluoxetine; Hippocampus; Hyperalgesia; Inflammation Mediators; Male; Microglia; Phenanthrenes; Rats, Sprague-Dawley | 2017 |
Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.
Topics: Animals; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Immunosuppressive Agents; Lupus Nephritis; Mice; Phenanthrenes; Spleen; Tripterygium | 2008 |
Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Colon; Disease Models, Animal; Diterpenes; Epoxy Compounds; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-23; Interleukin-4; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappaB-Inducing Kinase; Phenanthrenes; Protein Serine-Threonine Kinases; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha | 2008 |
Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.
Topics: Angiogenesis Inhibitors; Animals; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Embryo, Nonmammalian; Epoxy Compounds; Neovascularization, Physiologic; Pentacyclic Triterpenes; Phenanthrenes; Plant Roots; Reverse Transcriptase Polymerase Chain Reaction; Terpenes; Tripterygium; Triterpenes; Zebrafish | 2009 |
Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Disease Models, Animal; Diterpenes; Drug Screening Assays, Antitumor; Epoxy Compounds; Humans; KB Cells; Mice; Mice, Inbred NOD; Mice, SCID; Mouth Neoplasms; Phenanthrenes | 2009 |
Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.
Topics: Administration, Oral; Analysis of Variance; Animals; Cell Line, Transformed; Cytokines; Cytoplasm; Disease Models, Animal; Diterpenes; Encephalomyelitis, Autoimmune, Experimental; Epoxy Compounds; HSP70 Heat-Shock Proteins; I-kappa B Proteins; Immunoprecipitation; Immunosuppressive Agents; Lymph Nodes; Macrophages; Mice; Myelin Proteolipid Protein; NF-kappa B; NF-KappaB Inhibitor alpha; Peptide Fragments; Phenanthrenes; Phosphorylation; Phytotherapy; RNA, Messenger; Signal Transduction; Time Factors; Tripterygium; Up-Regulation | 2009 |
Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Diffusion; Disease Models, Animal; Diterpenes; Drug Carriers; Drug Delivery Systems; Epoxy Compounds; Erythema; Ethanol; Female; Liposomes; Male; Particle Size; Permeability; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2010 |
Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.
Topics: Aging; Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Disease Progression; Diterpenes; Epoxy Compounds; GTP-Binding Proteins; Integrases; Kidney; Mice; Mice, Mutant Strains; Mutation; Myxovirus Resistance Proteins; Phenanthrenes; Polycystic Kidney, Autosomal Dominant; Time Factors; TRPP Cation Channels | 2010 |
Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Disease Models, Animal; Diterpenes; Epoxy Compounds; Exploratory Behavior; Glial Fibrillary Acidic Protein; Gliosis; Immunosuppressive Agents; Inflammation; Janus Kinase 2; Male; Neurofilament Proteins; Phenanthrenes; Psychomotor Performance; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries; STAT3 Transcription Factor | 2010 |
Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.
Topics: Administration, Oral; Animals; Cell Line; Complement Membrane Attack Complex; Cytoprotection; Desmin; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Glomerulonephritis, Membranous; Heymann Nephritis Antigenic Complex; Immunoglobulin G; Immunosuppressive Agents; Mice; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phenanthrenes; Podocytes; Proteinuria; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Signal Transduction; Tacrolimus; Time Factors | 2010 |
Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function.
Topics: Animals; Blood Glucose; Cyclosporine; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Glucose Tolerance Test; Graft Rejection; Graft Survival; Immunosuppressive Agents; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred NOD; Phenanthrenes; Time Factors; Transplantation, Homologous; Weight Gain | 2010 |
[The effect of triptolide on the expression of BCL-2, ICE in pulmonary tissue of asthmatic guinea pig].
Topics: Animals; Asthma; Caspases; Disease Models, Animal; Diterpenes; Epoxy Compounds; Guinea Pigs; Interleukin-1 Receptor-Associated Kinases; Lung; Male; Phenanthrenes; Proto-Oncogene Proteins c-bcl-2; Tripterygium | 2001 |
The effects of triptolide on airway remodelling and transforming growth factor-β₁/Smad signalling pathway in ovalbumin-sensitized mice.
Topics: Airway Remodeling; Allergens; Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Dexamethasone; Disease Models, Animal; Diterpenes; Enzyme-Linked Immunosorbent Assay; Epoxy Compounds; Female; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Ovalbumin; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1 | 2011 |
Effectiveness of triptolide-coated stent on decreasing inflammation and attenuation of intimal hyperplasia in a pig after coronary angioplasty.
Topics: Analysis of Variance; Angioplasty, Balloon, Coronary; Animals; Biomarkers; Disease Models, Animal; Diterpenes; Drug-Eluting Stents; Epoxy Compounds; Immunosuppressive Agents; Phenanthrenes; Swine; Tunica Intima | 2011 |
Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production.
Topics: Animals; Antibodies, Monoclonal; Cell Movement; Disease Models, Animal; Diterpenes; Epoxy Compounds; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Interleukin-17; Liver; Liver Diseases; Mice; Mice, Inbred C57BL; Neutrophils; Phenanthrenes; Phytotherapy; Reperfusion Injury; STAT3 Transcription Factor; Tripterygium | 2011 |
Triptolide increases transcript and protein levels of survival motor neurons in human SMA fibroblasts and improves survival in SMA-like mice.
Topics: Animals; Apoptosis; Blotting, Western; Body Weight; Cell Culture Techniques; Cell Line; Cell Survival; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Fibroblasts; Gemini of Coiled Bodies; Humans; Kaplan-Meier Estimate; Mice; Mice, Knockout; Molecular Structure; Motor Neurons; Muscular Atrophy, Spinal; Neuroprotective Agents; Phenanthrenes; Real-Time Polymerase Chain Reaction; Survival of Motor Neuron 2 Protein; Transcription, Genetic; Tripterygium; Up-Regulation | 2012 |
Anti-inflammatory and neuroprotective effects of triptolide on traumatic brain injury in rats.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain Edema; Brain Injuries; Disease Models, Animal; Diterpenes; Epoxy Compounds; Inflammation Mediators; Male; Neurons; Neuroprotective Agents; Phenanthrenes; Rats; Rats, Sprague-Dawley; Recovery of Function | 2012 |
NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Neoplasm Metastasis; NF-kappa B; Norepinephrine Plasma Membrane Transport Proteins; Paraganglioma; Phenanthrenes; Pheochromocytoma; Rats; RNA Interference; Transcription, Genetic; Tumor Burden | 2012 |
Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cells, Cultured; Culture Media, Conditioned; Disease Models, Animal; Diterpenes; Epoxy Compounds; Gene Expression; Hippocampus; Immunologic Factors; Microglia; Neurons; Neuroprotective Agents; Peptide Fragments; Phenanthrenes; Protein Multimerization; Rats; RNA, Messenger; Synaptophysin; Vesicular Transport Proteins | 2012 |
Spinal cannabinoid receptor type 2 agonist reduces mechanical allodynia and induces mitogen-activated protein kinase phosphatases in a rat model of neuropathic pain.
Topics: 4-Nitrophenylphosphatase; Animals; Disease Models, Animal; Diterpenes; Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 6; Epoxy Compounds; Gene Expression Regulation; Hyperalgesia; Immunosuppressive Agents; Indoles; Male; Mitogen-Activated Protein Kinase Phosphatases; Nerve Tissue Proteins; Neuralgia; Phenanthrenes; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Signal Transduction; Spinal Cord; Time Factors | 2012 |
The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response.
Topics: Animals; Autoimmune Diseases; Cytokines; Disease Models, Animal; Diterpenes; Down-Regulation; Epoxy Compounds; Female; Immunosuppressive Agents; Injections, Intraperitoneal; Mice; Mice, Inbred Strains; Phenanthrenes; Retinitis; Th1 Cells; Uveitis | 2003 |
Protection effect of triptolide to liver injury in rats with severe acute pancreatitis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Immunohistochemistry; Interleukin-6; Liver; Liver Diseases; Male; NF-kappa B; Pancreatitis; Phenanthrenes; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2005 |
Experimental AA amyloidosis in mice is inhibited by treatment with triptolide, a purified traditional Chinese medicine.
Topics: Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Mice; Mice, Inbred ICR; Phenanthrenes; Serum Amyloid A Protein; Tripterygium | 2007 |
Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Diterpenes; Drug Evaluation, Preclinical; Epoxy Compounds; Hemodynamics; Hypertension, Pulmonary; Immunosuppressive Agents; Male; Monocrotaline; Neovascularization, Pathologic; Phenanthrenes; Pneumonectomy; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Time Factors; Tunica Intima | 2000 |