triptolide has been researched along with Chemical and Drug Induced Liver Injury in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.00) | 29.6817 |
| 2010's | 28 (56.00) | 24.3611 |
| 2020's | 21 (42.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, JQ; Liu, LF; Sun, FY; Wang, XN; Xia, WR; Xin, GZ; Zhong, ZJ | 1 |
| Feng, Z; Fu, L; Li, C; Shen, M; Xie, T; Xu, G; Yu, Z; Zhang, L; Zhou, J; Zhou, L; Zhou, X; Zhu, H | 1 |
| Cheng, Y; Dai, M; Li, F; Ma, X; Peng, W; Wang, C; Zhang, T; Zhao, Q | 1 |
| Chen, GF; Hu, YQ; Huang, K; Liu, CH; Liu, YT; Wang, YL; Yang, T; Zhou, H | 1 |
| Jiang, Z; Nong, C; Tang, Q; Wang, J; Yu, Q; Yuan, Z; Zhang, H; Zhang, L; Zhou, S; Zhu, Y | 1 |
| Huang, X; Jiang, ZZ; Liu, L; Mohammed, I; Sun, LX; Wang, T; Wang, XZ; Xing, X; Xu, XT; Zhang, LY; Zhang, X | 1 |
| Jiang, Z; Liang, P; Yu, Q; Yuan, Z; Zhang, L; Zhou, S | 1 |
| Chen, X; Nong, C; Sun, L; Wang, X; Xue, R; Yu, Z; Zhang, L; Zhang, M; Zhang, Y | 1 |
| Chen, X; Li, M; Liu, C; Luo, Q; Qiu, F; Sun, X; Tao, Y | 1 |
| Chen, X; Du, T; Gong, H; Guo, L; Hou, Z; Ji, M; Li, H; Li, W; Wang, M; Wang, W; Wei, S; Yan, M; You, S; Zhang, B | 1 |
| Dong, H; Gao, Z; Li, Y; Qian, R; Shao, F; Wang, C; Wang, K; Zhao, J; Zhu, K; Zhu, Z | 1 |
| Cui, D; Fu, R; Liu, W; Ma, W; Tang, Y; Xu, D; Yan, C; Yue, S | 1 |
| Baig, MMFA; Hasnat, M; Jiang, Z; Khan, A; Naveed, M; Raza, F; Su, Y; Sun, L; Ullah, A; Xu, D; Yuan, Z; Zhang, L | 1 |
| Jiang, ZZ; Luo, L; Miao, YY; Shu, T; Wang, H; Zhang, LY | 1 |
| Tao, K; Wei, CB; Zhang, JW; Zhang, QH; Zhou, LD | 1 |
| Dai, MY; Huang, JF; Li, F; Xiao, XR; Zhang, T; Zhao, Q; Zhu, WF | 1 |
| Huang, J; Li, F; Xiao, X; Zhang, T; Zhao, Q | 1 |
| Lu, D; Tong, Y; Wu, B; Zhao, H | 1 |
| Feng, Z; Fu, L; Geng, S; Li, M; Lu, W; Lu, Y; Zhou, L; Zhou, X | 1 |
| Gong, X; Gonzalez, FJ; Krausz, KW; Lu, D; Luo, Y; Mu, X; Su, S; Takahashi, S; Wang, K; Wang, Q; Xie, C; Zhao, J | 1 |
| Han, J; Wang, G; Xia, L; Yao, W; Zhou, Y | 1 |
| Hu, C; Ke, J; Li, H; Tang, X; Wu, L; Xiong, Y; Yu, X | 1 |
| Gong, H; Guo, L; Hou, Z; Li, Y; Yan, M; Zhang, B | 1 |
| Berends, C; Buckley, C; de Potter, CMJ; Dear, JW; Del Pozo, J; Mullins, JJ; Schneemann, S; Tucker, C; Vliegenthart, ADB; Webb, DJ; Wei, C | 1 |
| Jiang, R; Tao, K; Wei, CB; Yuan, CS; Zhang, QH; Zhou, LD | 1 |
| Chen, JN; Dou, YX; Huang, QH; Huang, YF; Li, YX; Su, ZR; Wang, L; Xie, JH; Xu, LQ; Zeng, HF | 1 |
| Feng, Z; Liu, Z; Zhou, C; Zhou, L; Zhou, X; Zhu, H | 1 |
| Cao, L-; Deng, Y; Fang, PF; Gong, H; Li, HD; Li, ZH; Ma, YX; Xiang, DX; Yan, M; Zhang, BK | 1 |
| Hu, Q; Huang, SY; Jia, LL; Jin, J; Su, HZ; Tan, QY; Xiao, J; Zhang, J; Zhu, SN | 1 |
| Gao, X; Gonzalez, FJ; Krausz, KW; Mu, X; Patel, DP; Shi, X; Wang, Q; Xie, C; Zhao, J | 1 |
| Ji, X; Liu, Z; Wang, S; Wang, X; Yao, Z; Zuo, S | 1 |
| Jiang, ZZ; Wang, XZ; Xue, RF; Zhang, LY; Zhang, SY; Zheng, YT | 1 |
| Huang, X; Ismail Abdelmotalab, M; Jiang, Z; Li, L; Liu, L; Pang, T; Sun, L; Wang, L; Wang, T; Wang, X; Xiao, L; Xing, X; Xu, D; Zhang, L | 1 |
| Jiang, ZZ; Wang, XZ; Xu, Y; Zhang, LY; Zhang, SY | 1 |
| Chen, X; Ding, J; Hasnat, M; Jiang, Z; Liang, P; Sun, L; Yuan, Z; Zhang, H; Zhang, L | 1 |
| Dong, S; Feng, Z; Liu, T; Liu, Z; Zhou, C; Zhou, L; Zhou, X | 1 |
| Chen, RX; Cheng, YX; Cui, Y; Ding, NN; Liu, C; Wang, JM; Zhang, LL | 1 |
| Li, Y; Shang, R; Xu, P; Yan, Z; Yang, L; Yu, Z | 1 |
| Hsiao, CD; Huo, J; Jiang, Z; Liu, K; Yu, Q; Zhang, L; Zhang, Y | 1 |
| Hasnat, M; Jiang, Z; Liang, P; Sun, L; Yuan, Z; Zhang, H; Zhang, L | 1 |
| Guan, CW; Huang, ZY; Jin, J; Li, J; Zhao, ZX | 1 |
| Cao, W; Jiang, Z; Sun, L; Wang, X; Yuan, Z; Zhang, L | 1 |
| Fu, X; Guan, C; Huang, M; Huang, Z; Jin, J; Li, J; Shen, F; Sun, X; Wang, W | 1 |
| Jia, Z; Qu, F; Qu, L; Wang, C; Wu, C; Zhang, J | 1 |
| Kong, LL; Li, H; Xu, L; Yang, HY; Yuan, M; Zhuang, XM | 1 |
| Fu, X; Huang, M; Huang, Z; Jin, J; Qiu, Y; Sun, X; Wang, W; Zhao, Z | 1 |
| Cheng, M; Liu, X; Liu, Y; Xiao, H | 1 |
| Fu, Q; Huang, X; Jiang, Z; Liu, L; Shu, B; Wang, T; Xue, M; Zhang, L; Zhang, P | 1 |
| Bao, X; Lu, Y; Shen, P; Sun, T; Xu, J; Zheng, W | 1 |
| Chen, Y; Du, P; Han, FM; Xia, QS; Zhang, XM | 1 |
1 review(s) available for triptolide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Recent advances in the pharmacological applications and liver toxicity of triptolide.
Topics: Chemical and Drug Induced Liver Injury; Diterpenes; Drug-Related Side Effects and Adverse Reactions; Epoxy Compounds; Hepatitis; Humans; Phenanthrenes | 2023 |
49 other study(ies) available for triptolide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Targeting tryptophan metabolism reveals Clematichinenoside AR alleviates triptolide-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Liver; Phenanthrenes; Rats; Saponins; Triterpenes; Tryptophan | 2022 |
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Topics: Activating Transcription Factor 4; Autophagy; Chemical and Drug Induced Liver Injury; eIF-2 Kinase; Humans | 2022 |
Metabolomics reveals the role of PPARα in Tripterygium Wilfordii-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Male; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentacyclic Triterpenes; Phenanthrenes; Plant Extracts; PPAR alpha; Tablets; Tripterygium | 2022 |
Antibiotic pretreatment promotes orally-administered triptolide absorption and aggravates hepatotoxicity and intestinal injury in mice.
Topics: Animals; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Diterpenes; Drug-Related Side Effects and Adverse Reactions; Epoxy Compounds; Inflammasomes; Liver; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Phenanthrenes | 2022 |
Th17/Treg imbalance mediates hepatic intolerance to exogenous lipopolysaccharide and exacerbates liver injury in triptolide induced excessive immune response.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Diterpenes; Epoxy Compounds; Immunity; Interleukin-17; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Phenanthrenes; T-Lymphocytes, Regulatory; Th17 Cells | 2022 |
Triptolide Induces Liver Injury by Regulating Macrophage Recruitment and Polarization via the Nrf2 Signaling Pathway.
Topics: Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Humans; Liver; Macrophages; NF-E2-Related Factor 2; Phenanthrenes; Signal Transduction | 2022 |
Obeticholic acid improved triptolide/lipopolysaccharide-induced hepatotoxicity by inhibiting caspase-11-GSDMD pyroptosis pathway.
Topics: Animals; Bile Acids and Salts; Caspases; Chemical and Drug Induced Liver Injury; Female; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pyroptosis; Tumor Necrosis Factor-alpha | 2023 |
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress.
Topics: Chemical and Drug Induced Liver Injury; Cytokines; Endoplasmic Reticulum Stress; Humans; Interleukin-12; Natural Killer T-Cells; Signal Transduction | 2023 |
Screening of major hepatotoxic components of Tripterygium wilfordii based on hepatotoxic injury patterns.
Topics: Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Mice; RNA, Messenger; Tripterygium; Tumor Necrosis Factor-alpha; Zebrafish | 2023 |
Variable p53/Nrf2 crosstalk contributes to triptolide-induced hepatotoxic process.
Topics: Chemical and Drug Induced Liver Injury; Diterpenes; Drug-Related Side Effects and Adverse Reactions; Epoxy Compounds; Humans; NF-E2-Related Factor 2; Phenanthrenes; Tumor Suppressor Protein p53 | 2023 |
Triptolide with hepatotoxicity and nephrotoxicity used in local delivery treatment of myocardial infarction by thermosensitive hydrogel.
Topics: Chemical and Drug Induced Liver Injury; Humans; Hydrogels; Myocardial Infarction; Myocytes, Cardiac | 2023 |
Mitochondria-dependent apoptosis in triptolide-induced hepatotoxicity is associated with the Drp1 activation.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Diterpenes; Dose-Response Relationship, Drug; Dynamins; Epoxy Compounds; Female; Hepatocytes; Humans; Mitochondria, Liver; Mitochondrial Dynamics; Phenanthrenes; Rats, Wistar | 2020 |
[Study on difference of liver toxicity and its molecular mechanisms caused by Tripterygium wilfordii multiglycoside and equivalent amount of triptolid in rats].
Topics: Animals; Caco-2 Cells; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Glycosides; Humans; Liver; Phenanthrenes; Plant Extracts; Rats; Rats, Wistar; Tandem Mass Spectrometry; Tripterygium | 2019 |
[Rotective Effects of Quercetin Against the Triptolide Induced Liver Injury and Relevant Mechanism Study].
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytokines; Diterpenes; Epoxy Compounds; Liver; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenanthrenes; Quercetin; Random Allocation | 2019 |
Gut microbiota protects from triptolide-induced hepatotoxicity: Key role of propionate and its downstream signalling events.
Topics: Animals; Anti-Bacterial Agents; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Fatty Acids, Volatile; Gastrointestinal Microbiome; Liver; Male; Mice, Inbred C57BL; Phenanthrenes; Propionates; Signal Transduction | 2020 |
Effect of CYP3A4 on liver injury induced by triptolide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dexamethasone; Diterpenes; Epoxy Compounds; Female; Ketoconazole; Liver; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Phenanthrenes | 2020 |
Circadian clock regulates hepatotoxicity of Tripterygium wilfordii through modulation of metabolism.
Topics: Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Circadian Rhythm; CLOCK Proteins; Cytochrome P-450 CYP3A; Diterpenes; Epoxy Compounds; Liver; Male; Membrane Proteins; Mice, Inbred C57BL; Mice, Knockout; Phenanthrenes; Plant Extracts; Toxicokinetics; Tripterygium | 2020 |
Catalpol coordinately regulates phase I and II detoxification enzymes of Triptolide through CAR and NRF2 pathways to reduce Triptolide-induced hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Disease Models, Animal; Diterpenes; Epoxy Compounds; Female; Glucuronosyltransferase; Hep G2 Cells; Hepatocytes; Humans; Iridoid Glucosides; Liver; Metabolic Detoxication, Phase I; Metabolic Detoxication, Phase II; NF-E2-Related Factor 2; Phenanthrenes; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction | 2020 |
Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Gene Expression Profiling; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Phenanthrenes; Transcriptome | 2020 |
Arctiin Antagonizes Triptolide-Induced Hepatotoxicity via Activation of Nrf2 Pathway.
Topics: Animals; Apoptosis; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Furans; Glucosides; Hep G2 Cells; Humans; Liver; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Phenanthrenes; Protective Agents; Signal Transduction | 2020 |
Metabolic profiling of 19 amino acids in triptolide-induced liver injured rats by gas chromatography-triple quadrupole mass spectrometry.
Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Female; Gas Chromatography-Mass Spectrometry; Molecular Structure; Phenanthrenes; Rats; Rats, Sprague-Dawley | 2021 |
Role of MicroRNA-155 in Triptolide-induced hepatotoxicity via the Nrf2-Dependent pathway.
Topics: Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Diterpenes; Down-Regulation; Epoxy Compounds; Gene Expression Regulation; Hepatocytes; Humans; Male; Mice; Mice, Inbred BALB C; MicroRNAs; NF-E2-Related Factor 2; Phenanthrenes | 2021 |
Characterization of Triptolide-Induced Hepatotoxicity by Imaging and Transcriptomics in a Novel Zebrafish Model.
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Diterpenes; Epoxy Compounds; Larva; Liver; MicroRNAs; Microscopy, Fluorescence; Phenanthrenes; Polymerase Chain Reaction; Sequence Analysis, RNA; Transcriptome; Zebrafish | 2017 |
Quercetin protects mouse liver against triptolide-induced hepatic injury by restoring Th17/Treg balance through Tim-3 and TLR4-MyD88-NF-κB pathway.
Topics: Animals; Antioxidants; Cells, Cultured; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Female; Forkhead Transcription Factors; Hepatitis A Virus Cellular Receptor 2; Liver; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-kappa B; Phenanthrenes; Quercetin; Signal Transduction; T-Lymphocytes, Regulatory; Th17 Cells; Toll-Like Receptor 4 | 2017 |
Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats.
Topics: Animals; Antioxidants; Apoptosis; Apoptosis Regulatory Proteins; Caspase 3; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Diterpenes; Epoxy Compounds; Hepatocytes; Inflammation Mediators; Lipid Peroxidation; Male; Oxidative Stress; Phenanthrenes; Protective Agents; Rats; Reactive Oxygen Species; Silymarin | 2018 |
Triptolide-induced hepatotoxicity can be alleviated when combined with Panax notoginseng saponins and Catapol.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Cell Line; Chemical and Drug Induced Liver Injury; Cytochromes c; Cytoprotection; Disease Models, Animal; Diterpenes; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Liver; Membrane Potential, Mitochondrial; Mitochondria, Liver; Mitochondrial Proteins; NF-E2-Related Factor 1; Panax; Phenanthrenes; Phytotherapy; Plants, Medicinal; Quaternary Ammonium Compounds; Rats, Sprague-Dawley; Saponins; Transcription Factors | 2018 |
Isoliquiritigenin protects against triptolide-induced hepatotoxicity in mice through Nrf2 activation.
Topics: Animals; Chalcones; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Liver; Liver Function Tests; Male; Malondialdehyde; Mice; Mice, Inbred ICR; NF-E2-Related Factor 2; Oxidative Stress; Phenanthrenes; Protective Agents; Signal Transduction | 2016 |
Licorice root extract and magnesium isoglycyrrhizinate protect against triptolide-induced hepatotoxicity via up-regulation of the Nrf2 pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Chemical and Drug Induced Liver Injury; Diterpenes; Down-Regulation; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Epoxy Compounds; Glycyrrhiza; Humans; Liver; Male; NF-E2-Related Factor 2; Oxidative Stress; Phenanthrenes; Plant Extracts; Plant Roots; Rats; Rats, Wistar; Saponins; Triterpenes; Up-Regulation | 2018 |
Metabolic alterations in triptolide-induced acute hepatotoxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diterpenes; Epoxy Compounds; Liver; Male; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Phenanthrenes; Spectrometry, Mass, Electrospray Ionization | 2018 |
Study on the efficacy and mechanism of triptolide on treating TNF transgenic mice with rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Apoptosis; Arthritis, Rheumatoid; Biomarkers; Bone Resorption; Chemical and Drug Induced Liver Injury; Cytokines; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Inflammation Mediators; Joints; Lymphocytes; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Osteoclasts; Phenanthrenes; Risk Assessment; Time Factors; Tumor Necrosis Factor-alpha | 2018 |
Activation of natural killer T cells contributes to triptolide-induced liver injury in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Female; Interferon-gamma; Interleukin-4; Leukocytes; Liver; Mice, Inbred C57BL; Natural Killer T-Cells; Phenanthrenes; Signal Transduction | 2018 |
Possible role of hepatic macrophage recruitment and activation in triptolide-induced hepatotoxicity.
Topics: Animals; Cell Line; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Lipopolysaccharides; Liver; Liver Function Tests; Macrophage Activation; Macrophages; Male; Mice, Inbred C57BL; Phagocytosis; Phenanthrenes | 2018 |
The role of neutrophils in triptolide-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chemokine CCL2; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Female; Humans; Interleukin-6; Intracellular Signaling Peptides and Proteins; Liver; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Neutrophils; Phenanthrenes; Tripterygium; Tumor Necrosis Factor-alpha | 2018 |
A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.
Topics: Alanine Transaminase; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Aspartate Aminotransferases; Bile Acids and Salts; Caspase Inhibitors; Chemical and Drug Induced Liver Injury; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Glucose; Glycogen; Imidazoles; Immunologic Factors; Indoles; Lipopolysaccharides; Liver; Mice, Inbred C57BL; Necrosis; Phenanthrenes; Signal Transduction | 2019 |
Catalpol and panax notoginseng saponins synergistically alleviate triptolide-induced hepatotoxicity through Nrf2/ARE pathway.
Topics: Antioxidant Response Elements; Cell Line; Chemical and Drug Induced Liver Injury; Diterpenes; Drug Synergism; Epoxy Compounds; Humans; Iridoid Glucosides; NF-E2-Related Factor 2; Panax notoginseng; Phenanthrenes; Saponins; Signal Transduction | 2019 |
In vivo protective effects of chlorogenic acid against triptolide-induced hepatotoxicity and its mechanism.
Topics: Animals; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Chlorogenic Acid; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Male; Mice; Oxidative Stress; Phenanthrenes; Protective Agents | 2018 |
Protective Effect of Vitamin C on Triptolide-induced Acute Hepatotoxicity in Mice through mitigation of oxidative stress.
Topics: Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Phenanthrenes; Protective Agents | 2019 |
Triptolide-induced hepatotoxicity via apoptosis and autophagy in zebrafish.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 5; Beclin-1; Chemical and Drug Induced Liver Injury; Diterpenes; Dose-Response Relationship, Drug; Embryo, Nonmammalian; Embryonic Development; Epoxy Compounds; Larva; Liver; Phenanthrenes; Zebrafish; Zebrafish Proteins | 2019 |
The role of inflammasome activation in Triptolide-induced acute liver toxicity.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cytokines; Diterpenes; Epoxy Compounds; Female; Inflammasomes; Liver; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; NF-KappaB Inhibitor alpha; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Phenanthrenes; Toll-Like Receptor 4 | 2019 |
[Tanshinone IIA protects against triptolide-induced liver injury via Nrf2/ARE activation].
Topics: Abietanes; Animals; Antioxidant Response Elements; Chemical and Drug Induced Liver Injury; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Glutamate-Cysteine Ligase; Heme Oxygenase-1; Liver; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Phenanthrenes; RNA, Messenger; Signal Transduction | 2013 |
Th17/Treg imbalance in triptolide-induced liver injury.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Immunosuppressive Agents; Interleukin-10; Interleukin-17; Liver; Mice; Mice, Inbred C57BL; Phenanthrenes; T-Lymphocytes, Regulatory; Th17 Cells; Transcription Factors | 2014 |
Activation of Nrf2 protects against triptolide-induced hepatotoxicity.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Alkylating; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Hep G2 Cells; Humans; Isothiocyanates; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Oxidative Stress; Phenanthrenes; Sulfoxides | 2014 |
Integrated targeted sphingolipidomics and transcriptomics reveal abnormal sphingolipid metabolism as a novel mechanism of the hepatotoxicity and nephrotoxicity of triptolide.
Topics: Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diterpenes; Epoxy Compounds; Ethnopharmacology; Kidney Diseases; Lethal Dose 50; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Phenanthrenes; Real-Time Polymerase Chain Reaction; Sphingolipids; Tandem Mass Spectrometry; Transcriptome; Tripterygium | 2015 |
Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.
Topics: Alanine Transaminase; Animals; Apoptosis Regulatory Proteins; Aspartate Aminotransferases; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Digoxin; Diterpenes; Epoxy Compounds; Gene Knockdown Techniques; Immunologic Factors; Male; Mice, Inbred BALB C; Molecular Docking Simulation; Oxidative Stress; Phenanthrenes; Protein Binding; Quinolines; RNA, Small Interfering | 2015 |
Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Gene Knockdown Techniques; Hep G2 Cells; Humans; Isoxazoles; Liver; Male; Mice, Inbred BALB C; Phenanthrenes; Receptors, Cytoplasmic and Nuclear; RNA, Small Interfering | 2015 |
[Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity].
Topics: Acetaminophen; Aristolochic Acids; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Diterpenes; Emodin; Epoxy Compounds; Hepatocytes; Humans; Mass Spectrometry; Metabolomics; Phenanthrenes | 2015 |
Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury.
Topics: Animals; Cell Respiration; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Fatty Liver; Female; Lactic Acid; Liver; Mitochondrial Membranes; Oxidation-Reduction; Oxidative Stress; Phenanthrenes; Plant Extracts; Rats; Rats, Sprague-Dawley; Tripterygium | 2011 |
Triptolide attenuate the oxidative stress induced by LPS/D-GalN in mice.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diterpenes; Epoxy Compounds; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Oxidative Stress; Phenanthrenes; Proteomics; Reactive Oxygen Species | 2012 |
Gene expression profile analyses of mice livers injured by Leigongteng.
Topics: Animals; Chemical and Drug Induced Liver Injury; Diterpenes; Drugs, Chinese Herbal; Epoxy Compounds; Gene Expression Profiling; Gene Expression Regulation; Male; Mice; Oligonucleotide Array Sequence Analysis; Phenanthrenes; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tripterygium | 2007 |