Compounds > triptolide
Page last updated: 2024-09-02

triptolide and Carcinoma, Non-Small Cell Lung

triptolide has been researched along with Carcinoma, Non-Small Cell Lung in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's11 (73.33)24.3611
2020's4 (26.67)2.80

Authors

AuthorsStudies
Cen, S; Ding, J; Gao, J; Xie, Y; Zhang, J; Zhou, J1
Chang, C; Chen, MW; Liu, Y; Qian, X; Ren, T; Tang, YJ; Wang, HS; Wang, MF1
Du, F; Hu, Y; Huang, Y; Ji, H; Kaboli, PJ; Li, M; Wang, S; Wu, M; Wu, X; Wu, Z; Xiao, Z; Zhao, Y; Zou, T1
Chen, J; Chen, MS; Deng, QD; Huang, LJ; Ke, YY; Lei, XP; Li, SP; Li, Z; Liang, L; Lin, ZX; Liu, Q; Yu, XY; Zhang, Y; Zhong, YH1
Bian, Z; Chen, H; Kashif Riaz, M; Lin, C; Lin, G; Lu, A; Tyagi, D; Wang, J; Wong, BCK; Yang, Z; Zhang, G; Zhang, X; Zhang, Y1
Guerram, M; Hamdi, AM; Hassan, HM; Jiang, ZZ; Ling, JW; Yousef, BA; Zhang, LY1
Dai, H; Kim, J; Nardi, I; Raz, D; Reno, T; Shen, B; Sztain, T; Wang, J; Yun, X; Zheng, L1
Chen, F; Fu, J; Hou, Y; Lv, H; Pi, J; Wang, H; Xu, Y; Xu, Z; Zhu, J1
Chen, X; Dai, S; Gong, Z; Li, Z; Qian, L; Wei, J; Xu, Z; Yan, Y; Zeng, S1
Ba, X; Chen, Z; Huang, Y; Shen, P; Tu, S; Wang, H; Wang, Y1
Guo, L; Jiang, P; Li, Y; Tong, X; Yan, M; Zhang, BK; Zhang, HM1
Song, Y; Wang, L1
Duan, M; Fan, W; Feng, J; Huo, R; Jia, Y; Jiao, J; Li, X; Zang, A; Zhang, J; Zhang, L; Zhu, X1
Fidler, JM; Kim, JY; Nelson, R; Raz, DJ; Reno, TA; Tong, SW; Wu, J1
Corey, C; D'Cunha, J; Kumar, A; Scott, I; Shiva, S1

Reviews

2 review(s) available for triptolide and Carcinoma, Non-Small Cell Lung

ArticleYear
The Roles of Plant-Derived Triptolide on Non-Small Cell Lung Cancer.
    Oncology research, 2019, Jul-12, Volume: 27, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Humans; Lung Neoplasms; Phenanthrenes; Signal Transduction

2019
[Advances on effects of triptolide with non-small cell lung cancer].
    Zhongguo fei ai za zhi = Chinese journal of lung cancer, 2013, Volume: 16, Issue:7

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Phenanthrenes; Signal Transduction

2013

Other Studies

13 other study(ies) available for triptolide and Carcinoma, Non-Small Cell Lung

ArticleYear
Triptolide reduces PD-L1 through the EGFR and IFN-γ/IRF1 dual signaling pathways.
    International immunopharmacology, 2023, Volume: 118

    Topics: B7-H1 Antigen; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Humans; Interferon Regulatory Factor-1; Interferon-gamma; Lung Neoplasms; Programmed Cell Death 1 Receptor; Signal Transduction

2023
Triptolide induces apoptosis through the calcium/calmodulin‑dependent protein kinase kinaseβ/AMP‑activated protein kinase signaling pathway in non‑small cell lung cancer cells.
    Oncology reports, 2020, Volume: 44, Issue:5

    Topics: AMP-Activated Protein Kinases; Apoptosis; Benzimidazoles; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diterpenes; Epoxy Compounds; Humans; Lung Neoplasms; Naphthalimides; Phenanthrenes; Phosphorylation; Pyrazoles; Pyrimidines; Signal Transduction

2020
The Anti-Tumor Mechanism and Target of Triptolide Based on Network Pharmacology and Molecular Docking.
    Recent patents on anti-cancer drug discovery, 2021, Volume: 16, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Chemokine CCL2; Collagen Type I, alpha 1 Chain; Colorectal Neoplasms; Cyclooxygenase 2; Diterpenes; Epoxy Compounds; Heme Oxygenase-1; Humans; Interleukin-17; Interleukin-6; Interleukin-8; Lung Neoplasms; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 8; Molecular Docking Simulation; Molecular Targeted Therapy; Network Pharmacology; NF-kappa B; Pancreatic Neoplasms; Phenanthrenes; Proto-Oncogene Proteins c-jun; Receptor, ErbB-2; STAT1 Transcription Factor; Structure-Activity Relationship; Toll-Like Receptors; Vascular Endothelial Growth Factor A

2021
Triptolide suppresses the growth and metastasis of non-small cell lung cancer by inhibiting β-catenin-mediated epithelial-mesenchymal transition.
    Acta pharmacologica Sinica, 2021, Volume: 42, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diterpenes; Epithelial-Mesenchymal Transition; Epoxy Compounds; Heterografts; Humans; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Phenanthrenes

2021
Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy.
    Scientific reports, 2017, 04-20, Volume: 7, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Carbonic Anhydrase IX; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diterpenes; Drug Delivery Systems; Epoxy Compounds; Humans; Liposomes; Lung Neoplasms; Male; Mice, Inbred BALB C; Phenanthrenes

2017
Biochemical and computational evaluation of Triptolide-induced cytotoxicity against NSCLC.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 103

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Diterpenes; Down-Regulation; Epoxy Compounds; Glutathione; Glycolysis; Humans; Lung Neoplasms; Molecular Docking Simulation; Molecular Dynamics Simulation; Phenanthrenes; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction

2018
Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3.
    International journal of cancer, 2018, 11-15, Volume: 143, Issue:10

    Topics: A549 Cells; Animals; Antineoplastic Agents, Alkylating; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diterpenes; Epigenesis, Genetic; Epoxy Compounds; Histones; Humans; Lung Neoplasms; Mice, Inbred NOD; Mice, SCID; Phenanthrenes; Up-Regulation; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2018
Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity.
    Toxicology and applied pharmacology, 2018, 11-01, Volume: 358

    Topics: A549 Cells; Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Antioxidant Response Elements; Carcinoma, Non-Small-Cell Lung; Diterpenes; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epoxy Compounds; Hep G2 Cells; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Phenanthrenes; Treatment Outcome; Tumor Burden; Xenograft Model Antitumor Assays

2018
Triptolide exerts an anti-tumor effect on non‑small cell lung cancer cells by inhibiting activation of the IL‑6/STAT3 axis.
    International journal of molecular medicine, 2019, Volume: 44, Issue:1

    Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Diterpenes; Epoxy Compounds; Humans; Interleukin-6; Lung Neoplasms; Neoplasm Proteins; Phenanthrenes; Signal Transduction; STAT3 Transcription Factor

2019
Combined Treatment with Triptolide and Tyrosine Kinase Inhibitors Synergistically Enhances Apoptosis in Non-small Cell Lung Cancer H1975 Cells but Not H1299 Cells through EGFR/Akt Pathway.
    Chemical & pharmaceutical bulletin, 2019, Aug-01, Volume: 67, Issue:8

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Diterpenes; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Epoxy Compounds; ErbB Receptors; Humans; Lung Neoplasms; Molecular Docking Simulation; Molecular Structure; Phenanthrenes; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship

2019
Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21.
    Molecular medicine reports, 2016, Volume: 13, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Diterpenes; Drug Screening Assays, Antitumor; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; MicroRNAs; Phenanthrenes; PTEN Phosphohydrolase; RNA Interference

2016
The triptolide derivative MRx102 inhibits Wnt pathway activation and has potent anti-tumor effects in lung cancer.
    BMC cancer, 2016, 07-11, Volume: 16

    Topics: A549 Cells; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Apoptosis; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Diterpenes; Drug Evaluation, Preclinical; Drug Therapy, Combination; Epoxy Compounds; Humans; Lung Neoplasms; Mice; Neoplasm Invasiveness; Phenanthrenes; Repressor Proteins; Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2016
Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer.
    PloS one, 2016, Volume: 11, Issue:8

    Topics: Acetylation; Antineoplastic Agents, Alkylating; Apoptosis; Carcinoma, Non-Small-Cell Lung; Diterpenes; Epoxy Compounds; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Organophosphates; Oxidative Stress; Phenanthrenes; Reactive Oxygen Species; RNA, Small Interfering; Sirtuin 3; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2016