triprolidine and Priapism

The increase in survival rate of β-thalassemia (β-thal) patients allowed for the appearance and manifestation of several complications in almost every organ system. Priapism in β-thal patients is rarely reported in the literature. We herein report and investigate the occurrence of two cases of priapism in two young patients with β-thal intermedia (β-TI). The potential mechanisms are due to either a cellular mechanism involving a thrombus obstructing the efferent venules of the corpora cavernosa leading to priapism, or a recently elucidated functional mechanism that causes alteration of nitric oxide (NO) response of the penis, ultimately causing priapism. This should incite clinicians for a close follow-up and monitoring of high risk patients who are susceptible to developing priapism.

Topics: Adrenergic beta-Antagonists; Adult; beta-Thalassemia; Combined Modality Therapy; Drug Combinations; Histamine H1 Antagonists; Humans; Male; Priapism; Propranolol; Pseudoephedrine; Severity of Illness Index; Treatment Outcome; Triprolidine