triprolidine and Peptic-Ulcer-Perforation

triprolidine has been researched along with Peptic-Ulcer-Perforation* in 1 studies

Other Studies

1 other study(ies) available for triprolidine and Peptic-Ulcer-Perforation

Article	Year
Prevention of secretagogue-induced ulcers in the rat. Gastroenterology, 1976, Volume: 70, Issue:5 PT.1 An inhibitor of gastric secretion, Pfizer UK -9040, a derivative of the antihistamine triprolidine, was given orally 50 to 100 mg per kg 1 hr before and at various times during a 24-hr subcutanwous infusion of ulcerogenic secretagogues. The higher the dose and the more frequent the dosage, the lower was the incidence, severity, number, and perforations of duodenal ulcers. The mechanisms by which UK -9040 prevents these ulcers is probably inhibition of gastric secretion. Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Duodenal Ulcer; Gastric Juice; Histamine; Male; Pentagastrin; Peptic Ulcer Perforation; Pyridines; Rats; Stimulation, Chemical; Triprolidine	1976

Article

Year

Prevention of secretagogue-induced ulcers in the rat.

Gastroenterology, 1976, Volume: 70, Issue:5 PT.1

An inhibitor of gastric secretion, Pfizer UK -9040, a derivative of the antihistamine triprolidine, was given orally 50 to 100 mg per kg 1 hr before and at various times during a 24-hr subcutanwous infusion of ulcerogenic secretagogues. The higher the dose and the more frequent the dosage, the lower was the incidence, severity, number, and perforations of duodenal ulcers. The mechanisms by which UK -9040 prevents these ulcers is probably inhibition of gastric secretion.

Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Duodenal Ulcer; Gastric Juice; Histamine; Male; Pentagastrin; Peptic Ulcer Perforation; Pyridines; Rats; Stimulation, Chemical; Triprolidine

1976