triprolidine has been researched along with Edema* in 2 studies
2 other study(ies) available for triprolidine and Edema
Article | Year |
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gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo.
We report that gp49B1, a mast cell membrane receptor with two immunoreceptor tyrosine-based inhibitory motifs (ITIM), constitutively inhibits mast cell activation-secretion induced by stem cell factor (SCF), a tissue-derived cytokine that also regulates mast cell development. The intradermal injection of SCF into the ears of gp49B1 null (gp49B(-/-)) mice elicited approximately 4- and 2.5-fold more degranulating mast cells and tissue swelling caused by edema, respectively, than in gp49B(+/+) mice. SCF did not induce tissue swelling in mast cell-deficient mice, and the responsiveness of gp49B(-/-) mice to mast cell-associated amine and lipid mediators was unaltered. When gp49B(+/+) and gp49B(-/-) mice were pretreated with antagonists of the amines, SCF-induced tissue swelling was reduced by >90% and 60%, respectively, and it was reduced by >90% in both genotypes when a cysteinyl leukotriene receptor antagonist was also provided. Hence, the dominant contribution of secretory granule amines to SCF-induced tissue swelling is the result of gp49B1-mediated inhibition of the production of cysteinyl leukotrienes by mast cells. Our findings also provide the first example of an ITIM-bearing receptor that constitutively suppresses inflammation generated in vivo independently of the adaptive immune response by a receptor that signals through intrinsic tyrosine kinase activity rather than immunoreceptor tyrosine-based activation motifs. Topics: Animals; Cell Degranulation; Chromones; Edema; Female; Inflammation; Male; Mast Cells; Membrane Glycoproteins; Metergoline; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Mutant Strains; Receptors, Immunologic; Recombinant Proteins; Stem Cell Factor; Triprolidine | 2003 |
Urate crystal induced inflammation in the rat: evidence for the combined actions of kinins, histamine and components of complement.
Topics: Animals; Carboxypeptidases; Colchicine; Complement System Proteins; Cyproheptadine; Edema; Female; Gout; Histamine; Kinins; Male; Methysergide; Promethazine; Rats; Serotonin; Tripelennamine; Triprolidine; Trypsin Inhibitors; Uric Acid | 1972 |