triphosphoric acid and HIV Coinfection studies

triphosphoric acid: used as water softener, peptizing agent, emulsifier & dispersing agent; ingredient of cleansers; meat preservative; RN given refers to parent cpd; structure

Research Excerpts

Excerpt	Relevance	Reference
"In the Promoting Maternal and Infant Survival Everywhere (PROMISE) trial, tenofovir disoproxil fumarate (TDF) use was associated with moderate or severe adverse pregnancy/neonatal outcomes."	9.34	Antenatal Intracellular Concentrations of Tenofovir Diphosphate and Emtricitabine Triphosphate and Associations Between Tenofovir Diphosphate and Severe Adverse Pregnancy Outcomes: IMPAACT-PROMISE (1077BF) Trial. ( Aizire, J; Brooks, KM; Butler, K; Cababasay, M; Fenton, T; Flynn, PM; Fowler, MG; Kiser, JJ; Mirochnick, M; Siberry, GK, 2020)
"In the Promoting Maternal and Infant Survival Everywhere (PROMISE) trial, tenofovir disoproxil fumarate (TDF) use was associated with moderate or severe adverse pregnancy/neonatal outcomes."	5.34	Antenatal Intracellular Concentrations of Tenofovir Diphosphate and Emtricitabine Triphosphate and Associations Between Tenofovir Diphosphate and Severe Adverse Pregnancy Outcomes: IMPAACT-PROMISE (1077BF) Trial. ( Aizire, J; Brooks, KM; Butler, K; Cababasay, M; Fenton, T; Flynn, PM; Fowler, MG; Kiser, JJ; Mirochnick, M; Siberry, GK, 2020)
"The coformulation of the nucleos(t)ide analogs (NA) tenofovir (TFV) disoproxil fumarate (TDF) and emtricitabine (FTC) is approved for HIV-infection treatment and prevention."	3.83	Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates. ( Anderson, PL; Bushman, LR; Castillo-Mancilla, JR; Chen, X; Kiser, JJ; MaWhinney, S; Seifert, SM; Zheng, JH, 2016)
"TAF-DBS was a randomized, crossover clinical study of TFV-DP in DBS, following directly observed dosing of 33%, 67%, or 100% of daily TAF (25 mg)/FTC (200 mg)."	2.94	Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots Following Tenofovir Alafenamide: The TAF-DBS Study. ( Anderson, PL; Brooks, KM; Bushman, LR; Castillo-Mancilla, J; Ibrahim, ME; Kiser, JJ; MaWhinney, S; McCallister, S; McHugh, C; Morrow, M; Yager, J, 2020)

Research

Studies (13)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Steady State Concentrations of TFV-DP for Different Dosing Patterns of Descovy

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (7.69)	29.6817
2010's	5 (38.46)	24.3611
2020's	7 (53.85)	2.80

Authors	Studies
Brooks, KM	4
Castillo-Mancilla, JR	3
Morrow, M	3
Mawhinney, S	4
Rowan, SE	1
Wyles, D	1
Blum, J	1
Huntley, R	1
Salah, L	1
Tehrani, A	1
Jimmerson, LC	1
Roon, L	1
Bushman, LR	5
Anderson, PL	6
Kiser, JJ	6
Yager, J	2
Brothers, J	1
Mulligan, K	1
Landovitz, R	1
Reirden, D	1
Glenny, C	1
Malhotra, M	1
Hosek, S	1
Seneviratne, HK	3
Matthews, RP	3
Zang, X	3
Barrett, SE	3
Koynov, A	3
Goodey, A	3
Heimbach, T	3
Weissler, VL	3
Leyssens, C	3
Reynders, T	3
Xu, Z	3
Rottey, S	3
Vargo, R	3
Robertson, MN	3
Stoch, SA	3
Iwamoto, M	3
Aizire, J	1
Mirochnick, M	1
Flynn, PM	1
Butler, K	1
Siberry, GK	1
Fenton, T	1
Cababasay, M	1
Fowler, MG	1
Castillo-Mancilla, J	2
Ibrahim, ME	1
McHugh, C	1
McCallister, S	1
Coyle, RP	1
Coleman, SS	1
Zheng, JH	3
Ellison, L	1
Xiao, D	1
Ling, KHJ	1
Custodio, J	1
Majeed, SR	1
Tarnowski, T	1
Rower, C	1
McAllister, K	1
Klein, B	1
Meditz, A	1
Guida, LA	1
Gollnest, T	1
Dinis de Oliveira, T	1
Rath, A	1
Hauber, I	1
Schols, D	1
Balzarini, J	1
Meier, C	1
Chen, X	1
Seifert, SM	1
Adams, JL	1
Sykes, C	1
Menezes, P	1
Prince, HM	1
Patterson, KB	1
Fransen, K	1
Crucitti, T	1
De Baetselier, I	1
Van Damme, L	1
Kashuba, AD	1
Rodriguez Orengo, JF	1
Santana, J	1
Febo, I	1
Diaz, C	1
Rodriguez, JL	1
Garcia, R	1
Font, E	1
Rosario, O	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Transgender Youth and PrEP: PK, Safety, Uptake & Adherence[NCT03652623]	Phase 1/Phase 2	48 participants (Anticipated)	Interventional	2018-07-23	Recruiting
The Cellular Pharmacology of F-TAF in Dried Blood Spots[NCT02962739]	Phase 1	38 participants (Actual)	Interventional	2016-03-31	Completed
Training in mHealth Prevention With MSM[NCT05044013]		90 participants (Anticipated)	Interventional	2023-11-15	Recruiting
A Comparative Effectiveness Demonstration Project for Linkage and Retention in PrEP Care for Men Who Have Sex With Men (PCA)[NCT03442192]		20 participants (Actual)	Interventional	2018-07-30	Terminated (stopped due to COVID erupted and change in policy making all visits throughout hospital telemedicine)
I-BrEATHe - Interactions Between Antiretrovirals And Transgender Hormones[NCT04050371]	Phase 4	48 participants (Actual)	Interventional	2017-08-03	Completed
IGHID 11601 - Measuring Antiretroviral Concentrations in Hair[NCT02768779]		84 participants (Actual)	Observational	2016-04-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Tenofovir diphosphate (TFV-DP) concentrations in dried blood spots (DBS) respective to dosing regimens of 33%, 67%, 100% of daily dosing. (NCT02962739)
Timeframe: Assessed weekly for 9 months

Tenofovir Diphosphate Concentration in Dried Blood Spots (DBS)

Intervention	fmol/punch (Mean)
DOT 33%	657
DOT 67%	1451
DOT 100%	2381

Tenofovir diphosphate concentration in dried blood spots at week 4 (NCT04050371)
Timeframe: After 4 weeks of daily observed dosing of FTC/TDF

Estradiol Concentration

Intervention	fmol/punch (Median)
Transgender Women	973.5
Transgender Men	1078

Estradiol concentrations in blood plasma by LC-MS/MS (NCT04050371)
Timeframe: Baseline and after 4 weeks of daily FTC/TDF

Total Testosterone

Intervention	pg/mL (Median)
	Week 0	Week 4
Transgender Men	24.2	23.1
Transgender Women	141.5	116

Total testosterone concentrations in blood plasma by LC-MS/MS (NCT04050371)
Timeframe: Baseline and after 4 weeks of daily FTC/TDF

Article	Year
Quantitation of intracellular triphosphate metabolites of antiretroviral agents in peripheral blood mononuclear cells (PBMCs) and corresponding cell count determinations: review of current methods and challenges. Expert opinion on drug metabolism & toxicology, 2018, Volume: 14, Issue:8 Topics: Anti-HIV Agents; Cell Count; Chromatography, Liquid; HIV Infections; Humans; Leukocytes, Mononuclear	2018
Intracellular studies of the nucleoside reverse transcriptase inhibitor active metabolites: a review. Puerto Rico health sciences journal, 2000, Volume: 19, Issue:1 Topics: Adult; Aged; Anti-HIV Agents; Antimetabolites; Cells, Cultured; Child; Chromatography, High Pressure	2000

Article	Year
Predictors of 007 triphosphate concentrations in dried blood spots in persons with hepatitis C and active drug or alcohol use. The Journal of antimicrobial chemotherapy, 2022, 04-27, Volume: 77, Issue:5 Topics: Dried Blood Spot Testing; Female; Hepacivirus; Hepatitis C; HIV Infections; Humans; Male; Polyphosph	2022
A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection. Journal of acquired immune deficiency syndromes (1999), 2023, 04-01, Volume: 92, Issue:4 Topics: Deoxyadenosines; Double-Blind Method; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Pre-Ex	2023
A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection. Journal of acquired immune deficiency syndromes (1999), 2023, 04-01, Volume: 92, Issue:4 Topics: Deoxyadenosines; Double-Blind Method; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Pre-Ex	2023
A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection. Journal of acquired immune deficiency syndromes (1999), 2023, 04-01, Volume: 92, Issue:4 Topics: Deoxyadenosines; Double-Blind Method; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Pre-Ex	2023
A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection. Journal of acquired immune deficiency syndromes (1999), 2023, 04-01, Volume: 92, Issue:4 Topics: Deoxyadenosines; Double-Blind Method; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Pre-Ex	2023
Antenatal Intracellular Concentrations of Tenofovir Diphosphate and Emtricitabine Triphosphate and Associations Between Tenofovir Diphosphate and Severe Adverse Pregnancy Outcomes: IMPAACT-PROMISE (1077BF) Trial. Journal of acquired immune deficiency syndromes (1999), 2020, 02-01, Volume: 83, Issue:2 Topics: Adenine; Anti-HIV Agents; Case-Control Studies; Chromatography, Liquid; Drug Combinations; Emtricita	2020
Intracellular Tenofovir-Diphosphate and Emtricitabine-Triphosphate in Dried Blood Spots Following Tenofovir Alafenamide: The TAF-DBS Study. Journal of acquired immune deficiency syndromes (1999), 2020, 07-01, Volume: 84, Issue:3 Topics: Adenine; Adolescent; Adult; Alanine; Anti-HIV Agents; Cross-Over Studies; Drug Combinations; Emtrici	2020

Article	Year
Pharmacokinetics of Emtricitabine/Tenofovir Disoproxil Fumarate Among Transgender Adolescents and Young Adults Without HIV Receiving Gender Affirming Hormones. AIDS research and human retroviruses, 2022, Volume: 38, Issue:11 Topics: Adolescent; Anti-HIV Agents; Emtricitabine; Female; HIV Infections; Hormones; Humans; Leukocytes, Mo	2022
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity toward Tenofovir Diphosphate. Drug metabolism and disposition: the biological fate of chemicals, 2023, Volume: 51, Issue:3 Topics: Adenosine Triphosphate; Adult; Anti-HIV Agents; Colorectal Neoplasms; Diphosphates; HIV Infections;	2023
Emtricitabine triphosphate in dried blood spots predicts future viremia in persons with HIV and identifies mismatch with self-reported adherence. AIDS (London, England), 2021, 10-01, Volume: 35, Issue:12 Topics: Anti-HIV Agents; Emtricitabine; HIV Infections; Humans; Medication Adherence; Polyphosphates; Prospe	2021
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Application of an intracellular assay for determination of tenofovir-diphosphate and emtricitabine-triphosphate from erythrocytes using dried blood spots. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Adenine; Biological Assay; Dried Blood Spot Testing; Emtricitabine; Erythrocytes; Hematocrit; HIV In	2016
Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues. Angewandte Chemie (International ed. in English), 2016, Apr-18, Volume: 55, Issue:17 Topics: Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cell Line; Cell Membrane Permeability; Esteras	2016
Model Linking Plasma and Intracellular Tenofovir/Emtricitabine with Deoxynucleoside Triphosphates. PloS one, 2016, Volume: 11, Issue:11 Topics: Adult; Anti-HIV Agents; Computer Simulation; Deoxyadenine Nucleotides; Deoxycytosine Nucleotides; Di	2016
Tenofovir diphosphate and emtricitabine triphosphate concentrations in blood cells compared with isolated peripheral blood mononuclear cells: a new measure of antiretroviral adherence? Journal of acquired immune deficiency syndromes (1999), 2013, Mar-01, Volume: 62, Issue:3 Topics: Adenine; Adult; Anti-HIV Agents; Blood Cells; Deoxycytidine; Diphosphates; Emtricitabine; Female; HI	2013

triphosphoric acid and HIV Coinfection