trioxsalen has been researched along with Xeroderma Pigmentosum in 6 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Xeroderma Pigmentosum: A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DNA of Xeroderma pigmentosum cells was crosslinked in vivo with trioxsalen and long wave length ultraviolet light and the cells were cultured in the presence of labelled thymidine for one hour." | 3.67 | Identification of the short dispersed repetitive DNA sequences isolated from the zones of initiation of DNA synthesis in human cells as Alu-elements. ( Altmann, H; Anachkova, B; Russev, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Z | 1 |
| Xu, XS | 1 |
| Harrison, J | 1 |
| Wang, G | 2 |
| Fendrick, JL | 1 |
| Hallick, LM | 1 |
| Raha, M | 1 |
| Seidman, MM | 1 |
| Glazer, PM | 1 |
| Cortés, F | 1 |
| Morgan, WF | 1 |
| Varcarcel, ER | 1 |
| Cleaver, JE | 2 |
| Wolff, S | 1 |
| Vuksanovic, L | 1 |
| Anachkova, B | 1 |
| Russev, G | 1 |
| Altmann, H | 1 |
6 other studies available for trioxsalen and Xeroderma Pigmentosum
| Article | Year |
|---|---|
Defining the function of xeroderma pigmentosum group F protein in psoralen interstrand cross-link-mediated DNA repair and mutagenesis.
Topics: Base Sequence; Cells, Cultured; Cross-Linking Reagents; DNA Adducts; DNA Damage; DNA Repair; DNA-Bin | 2004 |
Psoralen photoinactivation of herpes simplex virus: monoadduct and cross-link repair by xeroderma pigmentosum and Fanconi's anemia cells.
Topics: Anemia, Aplastic; Cell Line; Cross-Linking Reagents; DNA Repair; Fanconi Anemia; Furocoumarins; Huma | 1984 |
Mutagenesis by third-strand-directed psoralen adducts in repair-deficient human cells: high frequency and altered spectrum in a xeroderma pigmentosum variant.
Topics: Base Sequence; Cell Line; DNA Damage; DNA Repair; Furocoumarins; Genes, Suppressor; Genetic Variatio | 1996 |
Both cross-links and monoadducts induced in DNA by psoralens can lead to sister chromatid exchange formation.
Topics: Bromodeoxyuridine; Cell Line; Cross-Linking Reagents; DNA; DNA Damage; DNA Repair; Fibroblasts; Furo | 1991 |
Unique cross-link and monoadduct repair characteristics of a xeroderma pigmentosum revertant cell line.
Topics: Cell Line; Cross-Linking Reagents; DNA Damage; DNA Repair; Endonucleases; Humans; Single-Strand Spec | 1987 |
Identification of the short dispersed repetitive DNA sequences isolated from the zones of initiation of DNA synthesis in human cells as Alu-elements.
Topics: DNA; DNA Replication; Endonucleases; Fibroblasts; Humans; Nucleic Acid Denaturation; Nucleic Acid Hy | 1985 |