trioxsalen has been researched along with Vitiligo in 21 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Vitiligo: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The various drug dosage schedules investigated included 9 groups: 0." | 2.65 | Safety and therapeutic effectiveness of 8-methoxypsoralen, 4,5',8-trimethylpsoralen, and psoralen in vitiligo. ( Fitzpatrick, TB; Mosher, DB; Pathak, MA, 1984) |
| "Trimethylpsoralen, psoralen and 8-methoxypsoralen were adminstered in 10 mg dosage orally to 37, 29 and 23 patients with vitiligo." | 2.64 | A comparative clinical evaluation of trimethylpsoralen, psoralen and 8-methoxypsoralen in treating vitiligo. ( Sehgal, VN, 1975) |
| "Vitiligo is a common, acquired condition of unknown etiology." | 1.29 | Oral photochemotherapy in vitiligo: follow-up, patient compliance. ( Ajam, ZA; al-Aboosi, MM, 1995) |
| "Although the treatment of vitiligo with plants containing photodynamically active compounds dates back as far as 1400 BC, the modern period of research began only in the 1930's leading to the development of oral psoralens, a coumarin derivative." | 1.26 | Case report: malignant melanoma arising during drug therapy for vitiligo. ( Forrest, HJ; Forrest, JB, 1980) |
| "This drug is widely used in the treatment of vitiligo and psoriasis." | 1.26 | Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen. ( Dudek, G; Mandula, BB; Pathak, MA, 1976) |
| "The treatment of vitiligo has been unsatisfactory." | 1.26 | Trimethoxypsoralen in vitiligo. ( Annamalai, R; Lal, MB; Subhan, SA; Vasantha, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (71.43) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sehgal, VN | 2 |
| Pathak, MA | 3 |
| Mosher, DB | 1 |
| Fitzpatrick, TB | 2 |
| Kenney, JA | 2 |
| Grimes, PE | 2 |
| Swart, RN | 1 |
| Herfst, MJ | 1 |
| van Vloten, WA | 1 |
| Chakrabarti, SG | 1 |
| Minus, HR | 1 |
| Pradhan, TK | 1 |
| Stolk, L | 1 |
| Siddiqui, AH | 1 |
| Cormane, RH | 1 |
| Forrest, JB | 1 |
| Forrest, HJ | 1 |
| al-Aboosi, MM | 1 |
| Ajam, ZA | 1 |
| Halder, RM | 1 |
| Battle, EF | 1 |
| Smith, EM | 1 |
| Chuan, MT | 1 |
| Tsai, YJ | 1 |
| Wu, MC | 1 |
| Shephard, SE | 1 |
| Panizzon, RG | 1 |
| Theodoridis, A | 1 |
| Tsambaos, D | 1 |
| Sivenas, C | 1 |
| Capetanakis, J | 1 |
| Bouattour, H | 1 |
| Chaabouni, M | 1 |
| Mandula, BB | 1 |
| Dudek, G | 1 |
| Annamalai, R | 1 |
| Subhan, SA | 1 |
| Vasantha, M | 1 |
| Lal, MB | 1 |
| Parrish, JA | 1 |
| Shea, C | 1 |
| Karadaglić, D | 1 |
| Stefanović, Z | 1 |
| Mijailović, B | 1 |
| Lerner, AB | 1 |
| Singh, M | 1 |
| Kanwar, AJ | 1 |
| Bharija, SC | 1 |
| Belhaj, MS | 1 |
| Ortel, B | 1 |
| Tanew, A | 1 |
| Hönigsmann, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Topical Silymarin Cream Versus Salicylic Acid Peeling in Treatment of Acne Vulgaris: Split Face Study[NCT04490967] | Phase 4 | 30 participants (Anticipated) | Interventional | 2021-04-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for trioxsalen and Vitiligo
| Article | Year |
|---|---|
The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.
Topics: Adult; Female; Humans; Hydroquinones; Male; Melanoma; Melanosis; Methoxsalen; Nevus, Pigmented; Para | 1992 |
2 trials available for trioxsalen and Vitiligo
| Article | Year |
|---|---|
Safety and therapeutic effectiveness of 8-methoxypsoralen, 4,5',8-trimethylpsoralen, and psoralen in vitiligo.
Topics: Ficusin; Follow-Up Studies; Furocoumarins; Humans; Melanins; Methoxsalen; Photochemotherapy; Photose | 1984 |
A comparative clinical evaluation of trimethylpsoralen, psoralen and 8-methoxypsoralen in treating vitiligo.
Topics: Coumarins; Female; Ficusin; Furans; Humans; Male; Trioxsalen; Vitiligo | 1975 |
18 other studies available for trioxsalen and Vitiligo
| Article | Year |
|---|---|
Role of tacrolimus (FK506) 0.1% ointment WW in vitiligo in children and imperatives of combine therapy with Trioxsalen and Silymarin suspension in progressive vitiligo.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Immunosuppressive Ag | 2009 |
How we treat vitiligo.
Topics: Administration, Oral; Administration, Topical; Child; Furocoumarins; Humans; Hydroquinones; Methods; | 1983 |
[Vitiligo and treatment with psoralen and ultraviolet light].
Topics: Adult; Aged; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Photochemotherapy; PUVA | 1983 |
Determination of trimethylpsoralen in blood, ophthalmic fluids, and skin.
Topics: Administration, Oral; Adult; Aged; Animals; Aqueous Humor; Chromatography, High Pressure Liquid; Fem | 1982 |
Serum levels of trimethylpsoralen after oral administration.
Topics: Administration, Oral; Furocoumarins; Humans; Trioxsalen; Vitiligo | 1981 |
Case report: malignant melanoma arising during drug therapy for vitiligo.
Topics: Adult; Furocoumarins; Humans; Male; Melanoma; Photochemotherapy; Trioxsalen; Vitiligo | 1980 |
Oral photochemotherapy in vitiligo: follow-up, patient compliance.
Topics: Administration, Oral; Adolescent; Adult; Evaluation Studies as Topic; Female; Follow-Up Studies; Hum | 1995 |
Cutaneous malignancies in patients treated with psoralen photochemotherapy (PUVA) for vitiligo.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Aged; Child; Child, Preschool; F | 1995 |
Effectiveness of psoralen photochemotherapy for vitiligo.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Photosensitizing Agents; PUVA Therapy; Retrospective | 1999 |
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy.
Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; Baths; DNA Adducts; Female; Humans | 1999 |
Oral trimethylpsoralen in the treatment of vitiligo.
Topics: Administration, Oral; Adult; Child; Coumarins; Drug Evaluation; Female; Humans; Male; Skin Pigmentat | 1976 |
[Comparative analytical study of the effects of psoralens in vitiligo (findings in 70 patients) (author's transl)].
Topics: Adolescent; Adult; Aged; Child; Drug Evaluation; Female; Furocoumarins; Humans; Male; Methoxsalen; M | 1978 |
Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen.
Topics: Animals; Biotransformation; Coumarins; Humans; Male; Mice; Photochemistry; Psoriasis; Structure-Acti | 1976 |
Trimethoxypsoralen in vitiligo.
Topics: Adult; Child; Coumarins; Female; Follow-Up Studies; Humans; Male; Methoxsalen; Ointments; Photothera | 1976 |
Photochemotherapy of vitiligo. Use of orally administered psoralens and a high-intensity long-wave ultraviolet light system.
Topics: Administration, Oral; Adult; Coumarins; Female; Humans; Methoxsalen; Trioxsalen; Ultraviolet Therapy | 1976 |
[Treatment of vitiligo using oral Trisoralen].
Topics: Administration, Oral; Adolescent; Adult; Child; Coumarins; Female; Humans; Male; Middle Aged; Trioxs | 1976 |
Daily psoralen therapy in vitiligo.
Topics: Drug Administration Schedule; Humans; PUVA Therapy; Trioxsalen; Vitiligo | 1987 |
Vitiligo treatment.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; DNA; Huma | 1986 |