trioxsalen has been researched along with Skin Diseases in 5 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Skin Diseases: Diseases involving the DERMIS or EPIDERMIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "DNA of Xeroderma pigmentosum cells was crosslinked in vivo with trioxsalen and long wave length ultraviolet light and the cells were cultured in the presence of labelled thymidine for one hour." | 3.67 | Identification of the short dispersed repetitive DNA sequences isolated from the zones of initiation of DNA synthesis in human cells as Alu-elements. ( Altmann, H; Anachkova, B; Russev, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kano, Y | 1 |
| Fujiwara, Y | 1 |
| Shephard, SE | 1 |
| Panizzon, RG | 1 |
| Carter, DM | 1 |
| Pan, M | 1 |
| Gaynor, A | 1 |
| McGuire, JS | 1 |
| Sibrack, L | 1 |
| Anachkova, B | 1 |
| Russev, G | 1 |
| Altmann, H | 1 |
| Hönigsmann, H | 1 |
1 review available for trioxsalen and Skin Diseases
| Article | Year |
|---|---|
Psoralen photochemotherapy--mechanisms, drugs, toxicity.
Topics: DNA; Erythema; Furocoumarins; Humans; Methoxsalen; Neoplasms, Radiation-Induced; Photosensitivity Di | 1986 |
4 other studies available for trioxsalen and Skin Diseases
| Article | Year |
|---|---|
Dyskeratosis congenita: survival, sister-chromatid exchange and repair following treatments with crosslinking agents.
Topics: Cell Survival; Cells, Cultured; Cross-Linking Reagents; Crossing Over, Genetic; Diagnosis, Different | 1982 |
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy.
Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; Baths; DNA Adducts; Female; Humans | 1999 |
Psoralen-DNA cross-linking photoadducts in dyskeratosis congenita: delay in excision and promotion of sister chromatid exchange.
Topics: Adolescent; Adult; Cells, Cultured; Chromatids; DNA; Dose-Response Relationship, Drug; Dose-Response | 1979 |
Identification of the short dispersed repetitive DNA sequences isolated from the zones of initiation of DNA synthesis in human cells as Alu-elements.
Topics: DNA; DNA Replication; Endonucleases; Fibroblasts; Humans; Nucleic Acid Denaturation; Nucleic Acid Hy | 1985 |