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trioxsalen and Psoriasis

trioxsalen has been researched along with Psoriasis in 38 studies

Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.

Research Excerpts

ExcerptRelevanceReference
"Fifty patients with chronic plaque psoriasis were treated with trioxsalen bath PUVA and 43 patients with oral methoxsalen PUVA."9.05Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis. ( Reunala, T; Salo, H; Turjanmaa, K, 1985)
"Twenty five patients with severe and extensive psoriasis were treated with trimethylpsoralen (trioxsalen) bath plus ultraviolet A (bath PUVA) combined with oral retinoid, etretinate (Ro 10-9359)."9.05Trimethylpsoralen bath plus ultraviolet A combined with oral retinoid (etretinate) in the treatment of severe psoriasis. ( Fräki, JE; Hollmen, A; Väätäinen, N, 1985)
"Areas within psoriasis plaques have been treated with UV-light alone, trioxsalen plus UV-light, and coal tar (liquid carbonis detergens) plus UV-light, using the 313, 365 and 405 nm wavelength bands in various doses."9.04Comparative treatment of psoriasis with UV-light, trioxsalen plus UV-light, and coal tar plus UV-light. ( Fischer, T, 1977)
"Photochemotherapeutic treatment of psoriasis with trioxsalen baths (0."9.04Treatment of psoriasis with trioxsalen baths and dysprosium lamps. ( Alsins, J; Fischer, T, 1976)
"It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited."7.70Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999)
"We performed a record linkage study of 337 male and 190 female patients with psoriasis treated with trioxsalen bath PUVA during the period 1977 to 1988 and the Finnish Cancer Registry (cancer incidence in the period 1977 to 1993)."7.69Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA. ( Hannuksela, A; Hannuksela, M; Karvonen, J; Pukkala, E, 1996)
"A thorough clinical follow-up study with regard to the occurrence of degenerative skin changes and cutaneous carcinomas was undertaken in 1982 in 149 patients with moderate to severe psoriasis treated with PUVA baths (trioxsalen + UVA)."7.67Long-term safety of trioxsalen bath PUVA treatment: an 8-year follow-up of 149 psoriasis patients. ( Berne, B; Fischer, T; Michaëlsson, G; Norén, P, 1984)
"Forty-five patients with psoriasis were treated with trioxsalen bath plus UVA."7.66Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results. ( Lassus, A; Salo, OP; Taskinen, J, 1981)
"Good results were achieved in psoriasis with trioxsalen baths and UVA in 92% of 158 patients during initial treatment and in 83% of 139 patients during long-term treatment."7.66Long-term local trioxsalen photochemotherapy in psoriasis. ( Hannuksela, M; Karvonen, J; Väätäinen, N, 1981)
"Seventy-four patients with psoriasis were treated using a trioxsalen bath (50 mg/150 l of water) and long wave ultraviolet light (UVA) given in an ordinary PUVA-cabin."7.66Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis. ( Hannuksela, M; Karvonen, J, 1978)
"Successful results have been reported for bath-psoralens plus ultraviolet A (PUVA) treatment of psoriasis with the use of either a low-sensitizing psoralen (methoxsalen) or a high-sensitizing psoralen (trioxsalen), but no evidence has been presented that phototoxicity would be a prerequisite for antipsoriatic activity of these treatments."5.06Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization. ( Jansén, CT; Koulu, LM, 1988)
"Fifty patients with chronic plaque psoriasis were treated with trioxsalen bath PUVA and 43 patients with oral methoxsalen PUVA."5.05Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis. ( Reunala, T; Salo, H; Turjanmaa, K, 1985)
"Twenty five patients with severe and extensive psoriasis were treated with trimethylpsoralen (trioxsalen) bath plus ultraviolet A (bath PUVA) combined with oral retinoid, etretinate (Ro 10-9359)."5.05Trimethylpsoralen bath plus ultraviolet A combined with oral retinoid (etretinate) in the treatment of severe psoriasis. ( Fräki, JE; Hollmen, A; Väätäinen, N, 1985)
"Areas within psoriasis plaques have been treated with UV-light alone, trioxsalen plus UV-light, and coal tar (liquid carbonis detergens) plus UV-light, using the 313, 365 and 405 nm wavelength bands in various doses."5.04Comparative treatment of psoriasis with UV-light, trioxsalen plus UV-light, and coal tar plus UV-light. ( Fischer, T, 1977)
"Photochemotherapeutic treatment of psoriasis with trioxsalen baths (0."5.04Treatment of psoriasis with trioxsalen baths and dysprosium lamps. ( Alsins, J; Fischer, T, 1976)
"It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited."3.70Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999)
"We performed a record linkage study of 337 male and 190 female patients with psoriasis treated with trioxsalen bath PUVA during the period 1977 to 1988 and the Finnish Cancer Registry (cancer incidence in the period 1977 to 1993)."3.69Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA. ( Hannuksela, A; Hannuksela, M; Karvonen, J; Pukkala, E, 1996)
"A thorough clinical follow-up study with regard to the occurrence of degenerative skin changes and cutaneous carcinomas was undertaken in 1982 in 149 patients with moderate to severe psoriasis treated with PUVA baths (trioxsalen + UVA)."3.67Long-term safety of trioxsalen bath PUVA treatment: an 8-year follow-up of 149 psoriasis patients. ( Berne, B; Fischer, T; Michaëlsson, G; Norén, P, 1984)
"Forty-five patients with psoriasis were treated with trioxsalen bath plus UVA."3.66Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results. ( Lassus, A; Salo, OP; Taskinen, J, 1981)
"Good results were achieved in psoriasis with trioxsalen baths and UVA in 92% of 158 patients during initial treatment and in 83% of 139 patients during long-term treatment."3.66Long-term local trioxsalen photochemotherapy in psoriasis. ( Hannuksela, M; Karvonen, J; Väätäinen, N, 1981)
"Seventy-four patients with psoriasis were treated using a trioxsalen bath (50 mg/150 l of water) and long wave ultraviolet light (UVA) given in an ordinary PUVA-cabin."3.66Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis. ( Hannuksela, M; Karvonen, J, 1978)
"Psoriasis is an autoimmune, chronic, inflammatory skin disease characterized by epidermal hyperplasia, proliferation of blood vessels, and infiltration of leukocytes in dermis and epidermis."1.40Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. ( Garg, T; Goyal, AK; Parnami, N; Rath, G, 2014)
"This drug is widely used in the treatment of vitiligo and psoriasis."1.26Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen. ( Dudek, G; Mandula, BB; Pathak, MA, 1976)
"The possible methods of treating psoriasis and results obtained are reviewed and the superior effectiveness of an approach reported in recent literature, an association of methoxalene per os and broad ultraviolet rays, is pointed out."1.26[Therapy of psoriasis]. ( Ormea, F, 1976)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199030 (78.95)18.7374
1990's6 (15.79)18.2507
2000's1 (2.63)29.6817
2010's1 (2.63)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Parnami, N1
Garg, T1
Rath, G1
Goyal, AK1
Snellman, E1
Klimenko, T1
Rantanen, T1
Fischer, T7
Hartvig, P1
Bondesson, U1
Väätäinen, N4
Salo, OP1
Lassus, A1
Taskinen, J3
Berne, B2
Michaëlsson, G1
Norén, P1
Pathak, MA2
Marciani, MS1
Guiotto, A1
Rodighiero, G1
Willis, I1
Vahvelainen, N1
Nore, P1
Hannuksela, M6
Karvonen, J5
De Rie, MA1
Van Eendenburg, JP1
Versnick, AC1
Stolk, LM1
Bos, JD1
Westerhof, W1
Hannuksela, A1
Pukkala, E2
Coven, TR2
Murphy, FP1
Gilleaudeau, P1
Cardinale, I2
Krueger, JG2
Walters, IB1
Shephard, SE1
Panizzon, RG1
Hannuksela-Svahn, A1
Sigurgeirsson, B1
Lindelöf, B1
Poikolainen, K1
Alsins, J1
Sehgal, VN2
Rege, VL2
Kharangate, VN2
Skogh, M1
Juhlin, L2
Shelley, WB1
Jublin, L1
Becker, SW1
Mandula, BB1
Dudek, G1
Ormea, F1
Reys, M1
Verbov, J1
Ros, AM1
Wennersten, G1
Turjanmaa, K1
Salo, H1
Reunala, T1
Koulu, LM1
Jansén, CT1
Moreno, G1
Hollmen, A1
Fräki, JE1
Kokkonen, EL1

Reviews

1 review available for trioxsalen and Psoriasis

ArticleYear
Photosensitization of mammalian cells by psoralens and porphyrins.
    Biochimie, 1986, Volume: 68, Issue:6

    Topics: Animals; Cell Membrane; Cell Nucleus; DNA; Ficusin; Furocoumarins; Hematoporphyrins; Light; Liposome

1986

Trials

8 trials available for trioxsalen and Psoriasis

ArticleYear
Randomized half-side comparison of narrowband UVB and trimethylpsoralen bath plus UVA treatments for psoriasis.
    Acta dermato-venereologica, 2004, Volume: 84, Issue:2

    Topics: Adult; Baths; Confidence Intervals; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Sa

2004
A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema.
    The British journal of dermatology, 1995, Volume: 132, Issue:6

    Topics: Eczema; Ficusin; Gels; Humans; Male; Methoxsalen; Psoriasis; PUVA Therapy; Trioxsalen

1995
Comparative treatment of psoriasis with UV-light, trioxsalen plus UV-light, and coal tar plus UV-light.
    Acta dermato-venereologica, 1977, Volume: 57, Issue:4

    Topics: Coal Tar; Coumarins; Drug Evaluation; Evaluation Studies as Topic; Humans; Psoriasis; Trioxsalen; Ul

1977
Treatment of psoriasis with trioxsalen baths and dysprosium lamps.
    Acta dermato-venereologica, 1976, Volume: 56, Issue:5

    Topics: Adolescent; Adult; Aged; Baths; Coumarins; Female; Humans; Male; Methoxsalen; Middle Aged; Photochem

1976
Photochemotherapy of psoriasis with 4,5',8-trimethylpsoralen.
    Dermatologica, 1975, Volume: 150, Issue:5

    Topics: Adolescent; Adult; Clinical Trials as Topic; Coumarins; Female; Heliotherapy; Humans; Male; Middle A

1975
Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis.
    Acta dermato-venereologica, 1985, Volume: 65, Issue:1

    Topics: Adult; Baths; Combined Modality Therapy; Follow-Up Studies; Furocoumarins; Humans; Photochemotherapy

1985
Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization.
    Journal of the American Academy of Dermatology, 1988, Volume: 18, Issue:5 Pt 1

    Topics: Adenosine Triphosphatases; Adolescent; Adult; Dose-Response Relationship, Drug; Erythema; Female; HL

1988
Trimethylpsoralen bath plus ultraviolet A combined with oral retinoid (etretinate) in the treatment of severe psoriasis.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:1 Pt 1

    Topics: Administration, Oral; Baths; Drug Therapy, Combination; Etretinate; Follow-Up Studies; Furocoumarins

1985

Other Studies

29 other studies available for trioxsalen and Psoriasis

ArticleYear
Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy.
    Artificial cells, nanomedicine, and biotechnology, 2014, Volume: 42, Issue:6

    Topics: Administration, Topical; Animals; Combined Modality Therapy; Disease Models, Animal; Humans; Liposom

2014
Plasma concentrations after bath treatment and oral administration of trioxsalen.
    Acta dermato-venereologica, 1980, Volume: 60, Issue:2

    Topics: Administration, Oral; Baths; Furocoumarins; Gas Chromatography-Mass Spectrometry; Humans; Photochemo

1980
Phototoxicity of topical trioxsalen.
    Acta dermato-venereologica, 1980, Volume: 60, Issue:4

    Topics: Administration, Topical; Adolescent; Adult; Aged; Female; Furocoumarins; Humans; Lichen Planus; Male

1980
Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results.
    Acta dermato-venereologica, 1981, Volume: 61, Issue:6

    Topics: Adolescent; Adult; Aged; Baths; Female; Furocoumarins; Humans; Male; Middle Aged; Photochemotherapy;

1981
Long-term safety of trioxsalen bath PUVA treatment: an 8-year follow-up of 149 psoriasis patients.
    Photo-dermatology, 1984, Volume: 1, Issue:1

    Topics: Adult; Female; Follow-Up Studies; Humans; Male; Middle Aged; Photochemotherapy; Psoriasis; PUVA Ther

1984
A study of the relationship between photosensitizing and therapeutic activity of 4,5',8-trimethylpsoralen, and its major metabolite 4,8-dimethyl, 5'-carboxypsoralen.
    The Journal of investigative dermatology, 1983, Volume: 81, Issue:6

    Topics: Animals; DNA; Female; Furocoumarins; Guinea Pigs; Humans; Male; Methoxsalen; Mice; Photochemistry; P

1983
Photochemotherapy: a new promising chemical derivative.
    Archives of dermatological research, 1982, Volume: 272, Issue:3-4

    Topics: Animals; Furocoumarins; Guinea Pigs; Mice; Mice, Hairless; Photochemotherapy; Photosensitivity Disor

1982
Determination of trioxsalen in human plasma in the picogram range by glass capillary gas chromatography mass spectrometry.
    Biomedical mass spectrometry, 1980, Volume: 7, Issue:11-12

    Topics: Chromatography, Liquid; Furocoumarins; Gas Chromatography-Mass Spectrometry; Humans; Microchemistry;

1980
Penetration of trioxsalen into skin from trioxsalen baths.
    Archives of dermatological research, 1981, Volume: 270, Issue:2

    Topics: Baths; Female; Furocoumarins; Humans; Male; Middle Aged; Photochemotherapy; Psoriasis; PUVA Therapy;

1981
Long-term local trioxsalen photochemotherapy in psoriasis.
    Dermatologica, 1981, Volume: 163, Issue:3

    Topics: Administration, Topical; Adolescent; Adult; Aged; Baths; Burns; Female; Furocoumarins; Humans; Male;

1981
Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA.
    Journal of the American Academy of Dermatology, 1996, Volume: 35, Issue:5 Pt 1

    Topics: Adolescent; Adult; Aged; Female; Finland; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; N

1996
Trimethylpsoralen bath PUVA is a remittive treatment for psoriasis vulgaris. Evidence that epidermal immunocytes are direct therapeutic targets.
    Archives of dermatology, 1998, Volume: 134, Issue:10

    Topics: Antigens, CD; Antigens, CD1; B7-2 Antigen; CD3 Complex; Epidermis; Female; Humans; Lymphocyte Activa

1998
PUVA-induced lymphocyte apoptosis: mechanism of action in psoriasis.
    Photodermatology, photoimmunology & photomedicine, 1999, Volume: 15, Issue:1

    Topics: Apoptosis; Cells, Cultured; Flow Cytometry; Humans; Keratinocytes; Methoxsalen; Photosensitizing Age

1999
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy.
    Dermatology (Basel, Switzerland), 1999, Volume: 199, Issue:2

    Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; Baths; DNA Adducts; Female; Humans

1999
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis.
    The British journal of dermatology, 1999, Volume: 141, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Confidence Intervals; Female;

1999
[Treatment of psoriasis with ultraviolet rays and trioxsalen bath].
    Lakartidningen, 1979, Oct-24, Volume: 76, Issue:43

    Topics: Baths; Furocoumarins; Humans; Photochemotherapy; Psoriasis; Trioxsalen

1979
Treatment of psoriasis: trioxalen and sunlight.
    International journal of dermatology, 1978, Volume: 17, Issue:3

    Topics: Adolescent; Adult; Child; Coumarins; Female; Follow-Up Studies; Humans; Male; Middle Aged; Photochem

1978
Trioxsalen vs methoxsalen in the treatment of psoriasis.
    Archives of dermatology, 1978, Volume: 114, Issue:9

    Topics: Coumarins; Humans; Methoxsalen; Photochemotherapy; Psoriasis; Trioxsalen

1978
Ultraviolet light inhibition of oriented fibrin formation in psoriasis.
    The British journal of dermatology, 1978, Volume: 99, Issue:4

    Topics: Crystallization; Fibrin; Humans; Male; Psoriasis; Trioxsalen; Ultraviolet Rays

1978
Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis.
    The British journal of dermatology, 1978, Volume: 99, Issue:6

    Topics: Adolescent; Adult; Aged; Baths; Blister; Dermatitis, Contact; Female; Furocoumarins; Humans; Male; M

1978
Trioxsalen bath and ultraviolet light treatment of psoriasis.
    Archives of dermatology, 1977, Volume: 113, Issue:6

    Topics: Baths; Coumarins; Humans; Psoriasis; Trioxsalen; Ultraviolet Therapy

1977
Trisoralen photochemotherapy.
    The Australasian journal of dermatology, 1977, Volume: 18, Issue:1

    Topics: Adolescent; Coumarins; Female; Humans; Male; Psoriasis; Trioxsalen; Ultraviolet Therapy

1977
Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen.
    Science (New York, N.Y.), 1976, Sep-17, Volume: 193, Issue:4258

    Topics: Animals; Biotransformation; Coumarins; Humans; Male; Mice; Photochemistry; Psoriasis; Structure-Acti

1976
[Therapy of psoriasis].
    Minerva medica, 1976, Nov-14, Volume: 67, Issue:55

    Topics: Coumarins; Humans; Methoxsalen; Psoriasis; Sunlight; Trioxsalen; Ultraviolet Therapy

1976
Psoralens for psoriasis.
    International journal of dermatology, 1975, Volume: 14, Issue:9

    Topics: Adolescent; Adult; Anthralin; Coumarins; Ficusin; Humans; Methoxsalen; Middle Aged; Psoriasis; Triox

1975
[Treatment of psoriasis with UV-light, tar and psoralens].
    Lakartidningen, 1975, Nov-12, Volume: 72, Issue:46

    Topics: Coal Tar; Coumarins; Humans; Methoxsalen; Psoriasis; Trioxsalen; Ultraviolet Therapy

1975
PUVA therapy for photosensitive psoriasis.
    Acta dermato-venereologica, 1987, Volume: 67, Issue:6

    Topics: Female; Humans; Male; Methoxsalen; Middle Aged; Photosensitivity Disorders; Psoriasis; PUVA Therapy;

1987
Carcinogenicity of trioxsalen bath PUVA.
    Journal of the American Academy of Dermatology, 1989, Volume: 21, Issue:4 Pt 1

    Topics: Carcinogens; Furocoumarins; Humans; Psoriasis; PUVA Therapy; Trioxsalen

1989
Short-contact trioxsalen cream PUVA.
    Photo-dermatology, 1985, Volume: 2, Issue:6

    Topics: Administration, Topical; Adult; Female; Furocoumarins; Humans; Male; Middle Aged; Psoriasis; PUVA Th

1985