trioxsalen and Psoriasis
trioxsalen has been researched along with Psoriasis in 38 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty patients with chronic plaque psoriasis were treated with trioxsalen bath PUVA and 43 patients with oral methoxsalen PUVA." | 9.05 | Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis. ( Reunala, T; Salo, H; Turjanmaa, K, 1985) |
| "Twenty five patients with severe and extensive psoriasis were treated with trimethylpsoralen (trioxsalen) bath plus ultraviolet A (bath PUVA) combined with oral retinoid, etretinate (Ro 10-9359)." | 9.05 | Trimethylpsoralen bath plus ultraviolet A combined with oral retinoid (etretinate) in the treatment of severe psoriasis. ( Fräki, JE; Hollmen, A; Väätäinen, N, 1985) |
| "Areas within psoriasis plaques have been treated with UV-light alone, trioxsalen plus UV-light, and coal tar (liquid carbonis detergens) plus UV-light, using the 313, 365 and 405 nm wavelength bands in various doses." | 9.04 | Comparative treatment of psoriasis with UV-light, trioxsalen plus UV-light, and coal tar plus UV-light. ( Fischer, T, 1977) |
| "Photochemotherapeutic treatment of psoriasis with trioxsalen baths (0." | 9.04 | Treatment of psoriasis with trioxsalen baths and dysprosium lamps. ( Alsins, J; Fischer, T, 1976) |
| "It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited." | 7.70 | Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999) |
| "We performed a record linkage study of 337 male and 190 female patients with psoriasis treated with trioxsalen bath PUVA during the period 1977 to 1988 and the Finnish Cancer Registry (cancer incidence in the period 1977 to 1993)." | 7.69 | Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA. ( Hannuksela, A; Hannuksela, M; Karvonen, J; Pukkala, E, 1996) |
| "A thorough clinical follow-up study with regard to the occurrence of degenerative skin changes and cutaneous carcinomas was undertaken in 1982 in 149 patients with moderate to severe psoriasis treated with PUVA baths (trioxsalen + UVA)." | 7.67 | Long-term safety of trioxsalen bath PUVA treatment: an 8-year follow-up of 149 psoriasis patients. ( Berne, B; Fischer, T; Michaëlsson, G; Norén, P, 1984) |
| "Forty-five patients with psoriasis were treated with trioxsalen bath plus UVA." | 7.66 | Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results. ( Lassus, A; Salo, OP; Taskinen, J, 1981) |
| "Good results were achieved in psoriasis with trioxsalen baths and UVA in 92% of 158 patients during initial treatment and in 83% of 139 patients during long-term treatment." | 7.66 | Long-term local trioxsalen photochemotherapy in psoriasis. ( Hannuksela, M; Karvonen, J; Väätäinen, N, 1981) |
| "Seventy-four patients with psoriasis were treated using a trioxsalen bath (50 mg/150 l of water) and long wave ultraviolet light (UVA) given in an ordinary PUVA-cabin." | 7.66 | Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis. ( Hannuksela, M; Karvonen, J, 1978) |
| "Successful results have been reported for bath-psoralens plus ultraviolet A (PUVA) treatment of psoriasis with the use of either a low-sensitizing psoralen (methoxsalen) or a high-sensitizing psoralen (trioxsalen), but no evidence has been presented that phototoxicity would be a prerequisite for antipsoriatic activity of these treatments." | 5.06 | Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization. ( Jansén, CT; Koulu, LM, 1988) |
| "Fifty patients with chronic plaque psoriasis were treated with trioxsalen bath PUVA and 43 patients with oral methoxsalen PUVA." | 5.05 | Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis. ( Reunala, T; Salo, H; Turjanmaa, K, 1985) |
| "Twenty five patients with severe and extensive psoriasis were treated with trimethylpsoralen (trioxsalen) bath plus ultraviolet A (bath PUVA) combined with oral retinoid, etretinate (Ro 10-9359)." | 5.05 | Trimethylpsoralen bath plus ultraviolet A combined with oral retinoid (etretinate) in the treatment of severe psoriasis. ( Fräki, JE; Hollmen, A; Väätäinen, N, 1985) |
| "Areas within psoriasis plaques have been treated with UV-light alone, trioxsalen plus UV-light, and coal tar (liquid carbonis detergens) plus UV-light, using the 313, 365 and 405 nm wavelength bands in various doses." | 5.04 | Comparative treatment of psoriasis with UV-light, trioxsalen plus UV-light, and coal tar plus UV-light. ( Fischer, T, 1977) |
| "Photochemotherapeutic treatment of psoriasis with trioxsalen baths (0." | 5.04 | Treatment of psoriasis with trioxsalen baths and dysprosium lamps. ( Alsins, J; Fischer, T, 1976) |
| "It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited." | 3.70 | Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999) |
| "We performed a record linkage study of 337 male and 190 female patients with psoriasis treated with trioxsalen bath PUVA during the period 1977 to 1988 and the Finnish Cancer Registry (cancer incidence in the period 1977 to 1993)." | 3.69 | Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA. ( Hannuksela, A; Hannuksela, M; Karvonen, J; Pukkala, E, 1996) |
| "A thorough clinical follow-up study with regard to the occurrence of degenerative skin changes and cutaneous carcinomas was undertaken in 1982 in 149 patients with moderate to severe psoriasis treated with PUVA baths (trioxsalen + UVA)." | 3.67 | Long-term safety of trioxsalen bath PUVA treatment: an 8-year follow-up of 149 psoriasis patients. ( Berne, B; Fischer, T; Michaëlsson, G; Norén, P, 1984) |
| "Forty-five patients with psoriasis were treated with trioxsalen bath plus UVA." | 3.66 | Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results. ( Lassus, A; Salo, OP; Taskinen, J, 1981) |
| "Good results were achieved in psoriasis with trioxsalen baths and UVA in 92% of 158 patients during initial treatment and in 83% of 139 patients during long-term treatment." | 3.66 | Long-term local trioxsalen photochemotherapy in psoriasis. ( Hannuksela, M; Karvonen, J; Väätäinen, N, 1981) |
| "Seventy-four patients with psoriasis were treated using a trioxsalen bath (50 mg/150 l of water) and long wave ultraviolet light (UVA) given in an ordinary PUVA-cabin." | 3.66 | Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis. ( Hannuksela, M; Karvonen, J, 1978) |
| "Psoriasis is an autoimmune, chronic, inflammatory skin disease characterized by epidermal hyperplasia, proliferation of blood vessels, and infiltration of leukocytes in dermis and epidermis." | 1.40 | Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. ( Garg, T; Goyal, AK; Parnami, N; Rath, G, 2014) |
| "This drug is widely used in the treatment of vitiligo and psoriasis." | 1.26 | Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen. ( Dudek, G; Mandula, BB; Pathak, MA, 1976) |
| "The possible methods of treating psoriasis and results obtained are reviewed and the superior effectiveness of an approach reported in recent literature, an association of methoxalene per os and broad ultraviolet rays, is pointed out." | 1.26 | [Therapy of psoriasis]. ( Ormea, F, 1976) |
Research
Studies (38)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (78.95) | 18.7374 |
| 1990's | 6 (15.79) | 18.2507 |
| 2000's | 1 (2.63) | 29.6817 |
| 2010's | 1 (2.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Parnami, N | 1 |
| Garg, T | 1 |
| Rath, G | 1 |
| Goyal, AK | 1 |
| Snellman, E | 1 |
| Klimenko, T | 1 |
| Rantanen, T | 1 |
| Fischer, T | 7 |
| Hartvig, P | 1 |
| Bondesson, U | 1 |
| Väätäinen, N | 4 |
| Salo, OP | 1 |
| Lassus, A | 1 |
| Taskinen, J | 3 |
| Berne, B | 2 |
| Michaëlsson, G | 1 |
| Norén, P | 1 |
| Pathak, MA | 2 |
| Marciani, MS | 1 |
| Guiotto, A | 1 |
| Rodighiero, G | 1 |
| Willis, I | 1 |
| Vahvelainen, N | 1 |
| Nore, P | 1 |
| Hannuksela, M | 6 |
| Karvonen, J | 5 |
| De Rie, MA | 1 |
| Van Eendenburg, JP | 1 |
| Versnick, AC | 1 |
| Stolk, LM | 1 |
| Bos, JD | 1 |
| Westerhof, W | 1 |
| Hannuksela, A | 1 |
| Pukkala, E | 2 |
| Coven, TR | 2 |
| Murphy, FP | 1 |
| Gilleaudeau, P | 1 |
| Cardinale, I | 2 |
| Krueger, JG | 2 |
| Walters, IB | 1 |
| Shephard, SE | 1 |
| Panizzon, RG | 1 |
| Hannuksela-Svahn, A | 1 |
| Sigurgeirsson, B | 1 |
| Lindelöf, B | 1 |
| Poikolainen, K | 1 |
| Alsins, J | 1 |
| Sehgal, VN | 2 |
| Rege, VL | 2 |
| Kharangate, VN | 2 |
| Skogh, M | 1 |
| Juhlin, L | 2 |
| Shelley, WB | 1 |
| Jublin, L | 1 |
| Becker, SW | 1 |
| Mandula, BB | 1 |
| Dudek, G | 1 |
| Ormea, F | 1 |
| Reys, M | 1 |
| Verbov, J | 1 |
| Ros, AM | 1 |
| Wennersten, G | 1 |
| Turjanmaa, K | 1 |
| Salo, H | 1 |
| Reunala, T | 1 |
| Koulu, LM | 1 |
| Jansén, CT | 1 |
| Moreno, G | 1 |
| Hollmen, A | 1 |
| Fräki, JE | 1 |
| Kokkonen, EL | 1 |
Reviews
1 review available for trioxsalen and Psoriasis
| Article | Year |
|---|---|
Photosensitization of mammalian cells by psoralens and porphyrins.
Topics: Animals; Cell Membrane; Cell Nucleus; DNA; Ficusin; Furocoumarins; Hematoporphyrins; Light; Liposome | 1986 |
Trials
8 trials available for trioxsalen and Psoriasis
| Article | Year |
|---|---|
Randomized half-side comparison of narrowband UVB and trimethylpsoralen bath plus UVA treatments for psoriasis.
Topics: Adult; Baths; Confidence Intervals; Female; Follow-Up Studies; Humans; Male; Middle Aged; Patient Sa | 2004 |
A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczema.
Topics: Eczema; Ficusin; Gels; Humans; Male; Methoxsalen; Psoriasis; PUVA Therapy; Trioxsalen | 1995 |
Comparative treatment of psoriasis with UV-light, trioxsalen plus UV-light, and coal tar plus UV-light.
Topics: Coal Tar; Coumarins; Drug Evaluation; Evaluation Studies as Topic; Humans; Psoriasis; Trioxsalen; Ul | 1977 |
Treatment of psoriasis with trioxsalen baths and dysprosium lamps.
Topics: Adolescent; Adult; Aged; Baths; Coumarins; Female; Humans; Male; Methoxsalen; Middle Aged; Photochem | 1976 |
Photochemotherapy of psoriasis with 4,5',8-trimethylpsoralen.
Topics: Adolescent; Adult; Clinical Trials as Topic; Coumarins; Female; Heliotherapy; Humans; Male; Middle A | 1975 |
Comparison of trioxsalen bath and oral methoxsalen PUVA in psoriasis.
Topics: Adult; Baths; Combined Modality Therapy; Follow-Up Studies; Furocoumarins; Humans; Photochemotherapy | 1985 |
Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization.
Topics: Adenosine Triphosphatases; Adolescent; Adult; Dose-Response Relationship, Drug; Erythema; Female; HL | 1988 |
Trimethylpsoralen bath plus ultraviolet A combined with oral retinoid (etretinate) in the treatment of severe psoriasis.
Topics: Administration, Oral; Baths; Drug Therapy, Combination; Etretinate; Follow-Up Studies; Furocoumarins | 1985 |
Other Studies
29 other studies available for trioxsalen and Psoriasis
| Article | Year |
|---|---|
Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy.
Topics: Administration, Topical; Animals; Combined Modality Therapy; Disease Models, Animal; Humans; Liposom | 2014 |
Plasma concentrations after bath treatment and oral administration of trioxsalen.
Topics: Administration, Oral; Baths; Furocoumarins; Gas Chromatography-Mass Spectrometry; Humans; Photochemo | 1980 |
Phototoxicity of topical trioxsalen.
Topics: Administration, Topical; Adolescent; Adult; Aged; Female; Furocoumarins; Humans; Lichen Planus; Male | 1980 |
Trioxsalen bath plus UVA treatment of psoriasis. Plasma concentration of the drug and clinical results.
Topics: Adolescent; Adult; Aged; Baths; Female; Furocoumarins; Humans; Male; Middle Aged; Photochemotherapy; | 1981 |
Long-term safety of trioxsalen bath PUVA treatment: an 8-year follow-up of 149 psoriasis patients.
Topics: Adult; Female; Follow-Up Studies; Humans; Male; Middle Aged; Photochemotherapy; Psoriasis; PUVA Ther | 1984 |
A study of the relationship between photosensitizing and therapeutic activity of 4,5',8-trimethylpsoralen, and its major metabolite 4,8-dimethyl, 5'-carboxypsoralen.
Topics: Animals; DNA; Female; Furocoumarins; Guinea Pigs; Humans; Male; Methoxsalen; Mice; Photochemistry; P | 1983 |
Photochemotherapy: a new promising chemical derivative.
Topics: Animals; Furocoumarins; Guinea Pigs; Mice; Mice, Hairless; Photochemotherapy; Photosensitivity Disor | 1982 |
Determination of trioxsalen in human plasma in the picogram range by glass capillary gas chromatography mass spectrometry.
Topics: Chromatography, Liquid; Furocoumarins; Gas Chromatography-Mass Spectrometry; Humans; Microchemistry; | 1980 |
Penetration of trioxsalen into skin from trioxsalen baths.
Topics: Baths; Female; Furocoumarins; Humans; Male; Middle Aged; Photochemotherapy; Psoriasis; PUVA Therapy; | 1981 |
Long-term local trioxsalen photochemotherapy in psoriasis.
Topics: Administration, Topical; Adolescent; Adult; Aged; Baths; Burns; Female; Furocoumarins; Humans; Male; | 1981 |
Cancer incidence among Finnish patients with psoriasis treated with trioxsalen bath PUVA.
Topics: Adolescent; Adult; Aged; Female; Finland; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; N | 1996 |
Trimethylpsoralen bath PUVA is a remittive treatment for psoriasis vulgaris. Evidence that epidermal immunocytes are direct therapeutic targets.
Topics: Antigens, CD; Antigens, CD1; B7-2 Antigen; CD3 Complex; Epidermis; Female; Humans; Lymphocyte Activa | 1998 |
PUVA-induced lymphocyte apoptosis: mechanism of action in psoriasis.
Topics: Apoptosis; Cells, Cultured; Flow Cytometry; Humans; Keratinocytes; Methoxsalen; Photosensitizing Age | 1999 |
Carcinogenic risk of bath PUVA in comparison to oral PUVA therapy.
Topics: 5-Methoxypsoralen; Administration, Oral; Administration, Topical; Baths; DNA Adducts; Female; Humans | 1999 |
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Confidence Intervals; Female; | 1999 |
[Treatment of psoriasis with ultraviolet rays and trioxsalen bath].
Topics: Baths; Furocoumarins; Humans; Photochemotherapy; Psoriasis; Trioxsalen | 1979 |
Treatment of psoriasis: trioxalen and sunlight.
Topics: Adolescent; Adult; Child; Coumarins; Female; Follow-Up Studies; Humans; Male; Middle Aged; Photochem | 1978 |
Trioxsalen vs methoxsalen in the treatment of psoriasis.
Topics: Coumarins; Humans; Methoxsalen; Photochemotherapy; Psoriasis; Trioxsalen | 1978 |
Ultraviolet light inhibition of oriented fibrin formation in psoriasis.
Topics: Crystallization; Fibrin; Humans; Male; Psoriasis; Trioxsalen; Ultraviolet Rays | 1978 |
Trioxsalen bath plus UVA effective and safe in the treatment of psoriasis.
Topics: Adolescent; Adult; Aged; Baths; Blister; Dermatitis, Contact; Female; Furocoumarins; Humans; Male; M | 1978 |
Trioxsalen bath and ultraviolet light treatment of psoriasis.
Topics: Baths; Coumarins; Humans; Psoriasis; Trioxsalen; Ultraviolet Therapy | 1977 |
Trisoralen photochemotherapy.
Topics: Adolescent; Coumarins; Female; Humans; Male; Psoriasis; Trioxsalen; Ultraviolet Therapy | 1977 |
Photochemotherapy: identification of a metabolite of 4, 5', 8-trimethylpsoralen.
Topics: Animals; Biotransformation; Coumarins; Humans; Male; Mice; Photochemistry; Psoriasis; Structure-Acti | 1976 |
[Therapy of psoriasis].
Topics: Coumarins; Humans; Methoxsalen; Psoriasis; Sunlight; Trioxsalen; Ultraviolet Therapy | 1976 |
Psoralens for psoriasis.
Topics: Adolescent; Adult; Anthralin; Coumarins; Ficusin; Humans; Methoxsalen; Middle Aged; Psoriasis; Triox | 1975 |
[Treatment of psoriasis with UV-light, tar and psoralens].
Topics: Coal Tar; Coumarins; Humans; Methoxsalen; Psoriasis; Trioxsalen; Ultraviolet Therapy | 1975 |
PUVA therapy for photosensitive psoriasis.
Topics: Female; Humans; Male; Methoxsalen; Middle Aged; Photosensitivity Disorders; Psoriasis; PUVA Therapy; | 1987 |
Carcinogenicity of trioxsalen bath PUVA.
Topics: Carcinogens; Furocoumarins; Humans; Psoriasis; PUVA Therapy; Trioxsalen | 1989 |
Short-contact trioxsalen cream PUVA.
Topics: Administration, Topical; Adult; Female; Furocoumarins; Humans; Male; Middle Aged; Psoriasis; PUVA Th | 1985 |