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trioxsalen and Melanoma

trioxsalen has been researched along with Melanoma in 7 studies

Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited."7.70Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999)
"It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited."3.70Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999)
"Cloudman (S91) murine melanoma cells were treated with 4'-hydroxymethyltrioxsalen (HMT), a bifunctional psoralen and exposed to long-wavelength (365 nm) ultraviolet light."3.66Dose-related effects of psoralen and ultraviolet light on the cell cycle of murine melanoma cells. ( Bartholomew, JC; Hearst, JE; Varga, JM; Wiesehahn, G, 1982)
"Although the treatment of vitiligo with plants containing photodynamically active compounds dates back as far as 1400 BC, the modern period of research began only in the 1930's leading to the development of oral psoralens, a coumarin derivative."1.26Case report: malignant melanoma arising during drug therapy for vitiligo. ( Forrest, HJ; Forrest, JB, 1980)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19905 (71.43)18.7374
1990's2 (28.57)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Borkovic, SP1
Alper, JC1
McDonald, CJ1
Varga, JM2
Wiesehahn, G1
Bartholomew, JC2
Hearst, JE1
Cohen, SR1
Burkholder, DE1
Carter, DM1
Forrest, JB1
Forrest, HJ1
Hannuksela-Svahn, A1
Sigurgeirsson, B1
Pukkala, E1
Lindelöf, B1
Berne, B1
Hannuksela, M1
Poikolainen, K1
Karvonen, J1
Lerner, AB1

Reviews

1 review available for trioxsalen and Melanoma

ArticleYear
The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.
    Pigment cell research, 1992, Volume: Suppl 2

    Topics: Adult; Female; Humans; Hydroquinones; Male; Melanoma; Melanosis; Methoxsalen; Nevus, Pigmented; Para

1992

Other Studies

6 other studies available for trioxsalen and Melanoma

ArticleYear
Stimulation of pigmentation in melanoma cells by trimethylpsoralen in the absence of ultraviolet irradiation.
    The British journal of dermatology, 1983, Volume: 108, Issue:5

    Topics: Animals; Cell Line; Darkness; Furocoumarins; Melanoma; Methoxsalen; Mice; Microscopy, Electron; Neop

1983
Dose-related effects of psoralen and ultraviolet light on the cell cycle of murine melanoma cells.
    Cancer research, 1982, Volume: 42, Issue:6

    Topics: Animals; Cell Cycle; Cell Line; DNA Replication; Furocoumarins; Melanoma; Mice; Neoplasms, Experimen

1982
Cell cycle analysis of cultured mammalian cells after exposure to 4,5',8-trimethylpsoralen and long-wave ultraviolet light.
    The Journal of investigative dermatology, 1981, Volume: 76, Issue:5

    Topics: Animals; Cell Cycle; Cells, Cultured; Fibroblasts; Furocoumarins; Humans; Melanoma; Mice; Neoplasms,

1981
Case report: malignant melanoma arising during drug therapy for vitiligo.
    Journal of surgical oncology, 1980, Volume: 13, Issue:4

    Topics: Adult; Furocoumarins; Humans; Male; Melanoma; Photochemotherapy; Trioxsalen; Vitiligo

1980
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis.
    The British journal of dermatology, 1999, Volume: 141, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Confidence Intervals; Female;

1999
4,5',8-Trimethylpsoralen.
    IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 1986, Volume: 40

    Topics: Adult; Animals; Chemical Phenomena; Chemistry; DNA; Female; Furocoumarins; Guinea Pigs; Humans; Mela

1986