trioxsalen has been researched along with Melanoma in 7 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited." | 7.70 | Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999) |
| "It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited." | 3.70 | Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999) |
| "Cloudman (S91) murine melanoma cells were treated with 4'-hydroxymethyltrioxsalen (HMT), a bifunctional psoralen and exposed to long-wavelength (365 nm) ultraviolet light." | 3.66 | Dose-related effects of psoralen and ultraviolet light on the cell cycle of murine melanoma cells. ( Bartholomew, JC; Hearst, JE; Varga, JM; Wiesehahn, G, 1982) |
| "Although the treatment of vitiligo with plants containing photodynamically active compounds dates back as far as 1400 BC, the modern period of research began only in the 1930's leading to the development of oral psoralens, a coumarin derivative." | 1.26 | Case report: malignant melanoma arising during drug therapy for vitiligo. ( Forrest, HJ; Forrest, JB, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (71.43) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borkovic, SP | 1 |
| Alper, JC | 1 |
| McDonald, CJ | 1 |
| Varga, JM | 2 |
| Wiesehahn, G | 1 |
| Bartholomew, JC | 2 |
| Hearst, JE | 1 |
| Cohen, SR | 1 |
| Burkholder, DE | 1 |
| Carter, DM | 1 |
| Forrest, JB | 1 |
| Forrest, HJ | 1 |
| Hannuksela-Svahn, A | 1 |
| Sigurgeirsson, B | 1 |
| Pukkala, E | 1 |
| Lindelöf, B | 1 |
| Berne, B | 1 |
| Hannuksela, M | 1 |
| Poikolainen, K | 1 |
| Karvonen, J | 1 |
| Lerner, AB | 1 |
1 review available for trioxsalen and Melanoma
| Article | Year |
|---|---|
The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.
Topics: Adult; Female; Humans; Hydroquinones; Male; Melanoma; Melanosis; Methoxsalen; Nevus, Pigmented; Para | 1992 |
6 other studies available for trioxsalen and Melanoma
| Article | Year |
|---|---|
Stimulation of pigmentation in melanoma cells by trimethylpsoralen in the absence of ultraviolet irradiation.
Topics: Animals; Cell Line; Darkness; Furocoumarins; Melanoma; Methoxsalen; Mice; Microscopy, Electron; Neop | 1983 |
Dose-related effects of psoralen and ultraviolet light on the cell cycle of murine melanoma cells.
Topics: Animals; Cell Cycle; Cell Line; DNA Replication; Furocoumarins; Melanoma; Mice; Neoplasms, Experimen | 1982 |
Cell cycle analysis of cultured mammalian cells after exposure to 4,5',8-trimethylpsoralen and long-wave ultraviolet light.
Topics: Animals; Cell Cycle; Cells, Cultured; Fibroblasts; Furocoumarins; Humans; Melanoma; Mice; Neoplasms, | 1981 |
Case report: malignant melanoma arising during drug therapy for vitiligo.
Topics: Adult; Furocoumarins; Humans; Male; Melanoma; Photochemotherapy; Trioxsalen; Vitiligo | 1980 |
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Confidence Intervals; Female; | 1999 |
4,5',8-Trimethylpsoralen.
Topics: Adult; Animals; Chemical Phenomena; Chemistry; DNA; Female; Furocoumarins; Guinea Pigs; Humans; Mela | 1986 |