trioxsalen has been researched along with Inflammation in 3 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Analog 19 was a more potent anti-inflammatory agent than the reference compound indomethacin and of comparable cytocompatibility to 8-MOP whereas analog 24 was a weaker inhibitor of inflammation than indomethacin and significantly more cytotoxic than 8-MOP." | 3.79 | Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives. ( Athanassopoulos, CM; Avgoustakis, K; Bariamis, SE; Hadjipavlou-Litina, D; Kontogiorgis, C; Marin, M; Papaioannou, D; Romeo, G; Sindona, G; Tsimali, Z, 2013) |
| " The most potent compound, namely TRX derivative 3, was studied for its anti-inflammatory activity in vivo on rat paw edema induced by carrageenan, and was found to be of almost identical activity to indomethacin." | 3.75 | Trioxsalen derivatives with lipoxygenase inhibitory activity. ( Athanassopoulos, CM; E Bariamis, S; Hadjipavlou-Litina, D; Militsopoulou, M; Papaioannou, D, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Bariamis, SE | 1 |
| Marin, M | 1 |
| Athanassopoulos, CM | 2 |
| Kontogiorgis, C | 1 |
| Tsimali, Z | 1 |
| Papaioannou, D | 2 |
| Sindona, G | 1 |
| Romeo, G | 1 |
| Avgoustakis, K | 1 |
| Hadjipavlou-Litina, D | 2 |
| E Bariamis, S | 1 |
| Militsopoulou, M | 1 |
3 other studies available for trioxsalen and Inflammation
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives.
Topics: Anti-Inflammatory Agents; Antioxidants; Dose-Response Relationship, Drug; Furocoumarins; Glycine max | 2013 |
Trioxsalen derivatives with lipoxygenase inhibitory activity.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biphenyl Compounds; Carrageenan; Edema; Female; Fre | 2009 |