trioxsalen has been researched along with Experimental Neoplasms in 4 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cloudman (S91) murine melanoma cells were treated with 4'-hydroxymethyltrioxsalen (HMT), a bifunctional psoralen and exposed to long-wavelength (365 nm) ultraviolet light." | 3.66 | Dose-related effects of psoralen and ultraviolet light on the cell cycle of murine melanoma cells. ( Bartholomew, JC; Hearst, JE; Varga, JM; Wiesehahn, G, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borkovic, SP | 1 |
| Alper, JC | 1 |
| McDonald, CJ | 1 |
| Varga, JM | 2 |
| Wiesehahn, G | 1 |
| Bartholomew, JC | 2 |
| Hearst, JE | 1 |
| Cohen, SR | 1 |
| Burkholder, DE | 1 |
| Carter, DM | 1 |
| Moreno, G | 1 |
1 review available for trioxsalen and Experimental Neoplasms
| Article | Year |
|---|---|
Photosensitization of mammalian cells by psoralens and porphyrins.
Topics: Animals; Cell Membrane; Cell Nucleus; DNA; Ficusin; Furocoumarins; Hematoporphyrins; Light; Liposome | 1986 |
3 other studies available for trioxsalen and Experimental Neoplasms
| Article | Year |
|---|---|
Stimulation of pigmentation in melanoma cells by trimethylpsoralen in the absence of ultraviolet irradiation.
Topics: Animals; Cell Line; Darkness; Furocoumarins; Melanoma; Methoxsalen; Mice; Microscopy, Electron; Neop | 1983 |
Dose-related effects of psoralen and ultraviolet light on the cell cycle of murine melanoma cells.
Topics: Animals; Cell Cycle; Cell Line; DNA Replication; Furocoumarins; Melanoma; Mice; Neoplasms, Experimen | 1982 |
Cell cycle analysis of cultured mammalian cells after exposure to 4,5',8-trimethylpsoralen and long-wave ultraviolet light.
Topics: Animals; Cell Cycle; Cells, Cultured; Fibroblasts; Furocoumarins; Humans; Melanoma; Mice; Neoplasms, | 1981 |