Page last updated: 2024-11-05

trioxsalen and Erythema

trioxsalen has been researched along with Erythema in 8 studies

Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.

Research Excerpts

ExcerptRelevanceReference
"Successful results have been reported for bath-psoralens plus ultraviolet A (PUVA) treatment of psoriasis with the use of either a low-sensitizing psoralen (methoxsalen) or a high-sensitizing psoralen (trioxsalen), but no evidence has been presented that phototoxicity would be a prerequisite for antipsoriatic activity of these treatments."5.06Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization. ( Jansén, CT; Koulu, LM, 1988)
"We sought to determine the time-course and dose-response characteristics of erythema induced by topical TMP, and to compare these parameters with those for topical 8-methoxypsoralen (MOP) within patients."1.32An intraindividual comparative study of psoralen-UVA erythema induced by bath 8-methoxypsoralen and 4, 5', 8-trimethylpsoralen. ( Dawe, RS; Ferguson, J; Ibbotson, SH; Man, I; McKinlay, J, 2003)
"Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer."1.31Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A. ( Rantanen, T; Snellman, E, 2001)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's1 (12.50)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Man, I1
McKinlay, J1
Dawe, RS1
Ferguson, J1
Ibbotson, SH1
Coupez, L2
Agache, PG2
Petigny, M1
Berg, M1
Ros, AM1
Berne, B1
Snellman, E1
Rantanen, T1
Marciani, S1
Guiotto, A1
Rodighiero, P1
Gia, O1
Rodighiero, G1
Pathak, MA1
Koulu, LM1
Jansén, CT1
Hönigsmann, H1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Characterisation of the Time-course Response of UV-induced Erythema[NCT04290273]10 participants (Anticipated)Interventional2023-09-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for trioxsalen and Erythema

ArticleYear
Psoralen photochemotherapy--mechanisms, drugs, toxicity.
    Current problems in dermatology, 1986, Volume: 15

    Topics: DNA; Erythema; Furocoumarins; Humans; Methoxsalen; Neoplasms, Radiation-Induced; Photosensitivity Di

1986

Trials

2 trials available for trioxsalen and Erythema

ArticleYear
Ultraviolet A phototherapy and trimethylpsoralen UVA photochemotherapy in polymorphous light eruption--a controlled study.
    Photodermatology, photoimmunology & photomedicine, 1994, Volume: 10, Issue:4

    Topics: Adult; Double-Blind Method; Erythema; Female; Humans; Male; Middle Aged; Photochemotherapy; Photosen

1994
Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization.
    Journal of the American Academy of Dermatology, 1988, Volume: 18, Issue:5 Pt 1

    Topics: Adenosine Triphosphatases; Adolescent; Adult; Dose-Response Relationship, Drug; Erythema; Female; HL

1988

Other Studies

5 other studies available for trioxsalen and Erythema

ArticleYear
An intraindividual comparative study of psoralen-UVA erythema induced by bath 8-methoxypsoralen and 4, 5', 8-trimethylpsoralen.
    Journal of the American Academy of Dermatology, 2003, Volume: 49, Issue:1

    Topics: Adult; Dose-Response Relationship, Drug; Erythema; Female; Humans; Male; Methoxsalen; Middle Aged; P

2003
Effect of UV-B erythema of psoralen, trimethylpsoralen, and 8 methoxypsoralen.
    Acta dermato-venereologica, 1980, Volume: 60, Issue:5

    Topics: Adult; Dose-Response Relationship, Drug; Erythema; Female; Ficusin; Furocoumarins; Humans; Male; Met

1980
Protective effect of trimethylpsoralen against UV-B erythema.
    Archives of dermatological research, 1980, Volume: 268, Issue:1

    Topics: Adolescent; Adult; Erythema; Female; Furocoumarins; Humans; Male; Trioxsalen; Ultraviolet Rays

1980
Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A.
    The British journal of dermatology, 2001, Volume: 144, Issue:3

    Topics: Adult; Aged; Baths; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Erythem

2001
Synthesis and photobiological properties of 4,8-dimethyl-5'-carboxypsoralen: a major metabolite of 4,5',8-trimethylpsoralen.
    Il Farmaco; edizione scientifica, 1979, Volume: 34, Issue:3

    Topics: Administration, Oral; Administration, Topical; Animals; Binding Sites; DNA; Edema; Erythema; Furocou

1979