trioxsalen has been researched along with Erythema in 8 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Successful results have been reported for bath-psoralens plus ultraviolet A (PUVA) treatment of psoriasis with the use of either a low-sensitizing psoralen (methoxsalen) or a high-sensitizing psoralen (trioxsalen), but no evidence has been presented that phototoxicity would be a prerequisite for antipsoriatic activity of these treatments." | 5.06 | Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization. ( Jansén, CT; Koulu, LM, 1988) |
| "We sought to determine the time-course and dose-response characteristics of erythema induced by topical TMP, and to compare these parameters with those for topical 8-methoxypsoralen (MOP) within patients." | 1.32 | An intraindividual comparative study of psoralen-UVA erythema induced by bath 8-methoxypsoralen and 4, 5', 8-trimethylpsoralen. ( Dawe, RS; Ferguson, J; Ibbotson, SH; Man, I; McKinlay, J, 2003) |
| "Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer." | 1.31 | Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A. ( Rantanen, T; Snellman, E, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Man, I | 1 |
| McKinlay, J | 1 |
| Dawe, RS | 1 |
| Ferguson, J | 1 |
| Ibbotson, SH | 1 |
| Coupez, L | 2 |
| Agache, PG | 2 |
| Petigny, M | 1 |
| Berg, M | 1 |
| Ros, AM | 1 |
| Berne, B | 1 |
| Snellman, E | 1 |
| Rantanen, T | 1 |
| Marciani, S | 1 |
| Guiotto, A | 1 |
| Rodighiero, P | 1 |
| Gia, O | 1 |
| Rodighiero, G | 1 |
| Pathak, MA | 1 |
| Koulu, LM | 1 |
| Jansén, CT | 1 |
| Hönigsmann, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Characterisation of the Time-course Response of UV-induced Erythema[NCT04290273] | 10 participants (Anticipated) | Interventional | 2023-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for trioxsalen and Erythema
| Article | Year |
|---|---|
Psoralen photochemotherapy--mechanisms, drugs, toxicity.
Topics: DNA; Erythema; Furocoumarins; Humans; Methoxsalen; Neoplasms, Radiation-Induced; Photosensitivity Di | 1986 |
2 trials available for trioxsalen and Erythema
| Article | Year |
|---|---|
Ultraviolet A phototherapy and trimethylpsoralen UVA photochemotherapy in polymorphous light eruption--a controlled study.
Topics: Adult; Double-Blind Method; Erythema; Female; Humans; Male; Middle Aged; Photochemotherapy; Photosen | 1994 |
Antipsoriatic, erythematogenic, and Langerhans cell marker depleting effect of bath-psoralens plus ultraviolet A treatment. Comparison of 8-methoxypsoralen and trimethylpsoralen photosensitization.
Topics: Adenosine Triphosphatases; Adolescent; Adult; Dose-Response Relationship, Drug; Erythema; Female; HL | 1988 |
5 other studies available for trioxsalen and Erythema
| Article | Year |
|---|---|
An intraindividual comparative study of psoralen-UVA erythema induced by bath 8-methoxypsoralen and 4, 5', 8-trimethylpsoralen.
Topics: Adult; Dose-Response Relationship, Drug; Erythema; Female; Humans; Male; Methoxsalen; Middle Aged; P | 2003 |
Effect of UV-B erythema of psoralen, trimethylpsoralen, and 8 methoxypsoralen.
Topics: Adult; Dose-Response Relationship, Drug; Erythema; Female; Ficusin; Furocoumarins; Humans; Male; Met | 1980 |
Protective effect of trimethylpsoralen against UV-B erythema.
Topics: Adolescent; Adult; Erythema; Female; Furocoumarins; Humans; Male; Trioxsalen; Ultraviolet Rays | 1980 |
Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A.
Topics: Adult; Aged; Baths; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Erythem | 2001 |
Synthesis and photobiological properties of 4,8-dimethyl-5'-carboxypsoralen: a major metabolite of 4,5',8-trimethylpsoralen.
Topics: Administration, Oral; Administration, Topical; Animals; Binding Sites; DNA; Edema; Erythema; Furocou | 1979 |