trioxsalen has been researched along with Di Guglielmo Disease in 3 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " It was determined that the highest longwave UV dosage damaged the HSV-2 virion as well as cross-linking the viral DNA." | 1.27 | Herpes simplex virus types 1 and 2 induce shutoff of host protein synthesis by different mechanisms in Friend erythroleukemia cells. ( Hill, TM; Sadler, JR; Sinden, RR, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hill, TM | 1 |
| Sinden, RR | 1 |
| Sadler, JR | 1 |
| Kunnev, D | 1 |
| Tsvetkov, L | 1 |
| Anachkova, B | 1 |
| Russev, G | 1 |
| Conconi, A | 1 |
| Widmer, RM | 1 |
| Koller, T | 1 |
| Sogo, JM | 1 |
3 other studies available for trioxsalen and Di Guglielmo Disease
| Article | Year |
|---|---|
Herpes simplex virus types 1 and 2 induce shutoff of host protein synthesis by different mechanisms in Friend erythroleukemia cells.
Topics: Animals; Cell Line; Dactinomycin; Genes, Viral; Globins; Leukemia, Erythroblastic, Acute; Mice; Simp | 1983 |
Clusters of replicons that fire simultaneously may be organized into superloops.
Topics: Animals; DNA; DNA Damage; DNA Replication; Gamma Rays; Leukemia, Erythroblastic, Acute; Mice; Novobi | 1997 |
Two different chromatin structures coexist in ribosomal RNA genes throughout the cell cycle.
Topics: Animals; Cell Cycle; Cell Line; Cell Nucleus; Chromatin; Chromosomes; Cross-Linking Reagents; DNA, R | 1989 |