trioxsalen has been researched along with Cystic Fibrosis of Pancreas in 2 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methoxsalen failed to increase I(sc)." | 1.30 | Psoralens: novel modulators of Cl- secretion. ( Bridges, RJ; Devor, DC; Frizzell, RA; Singh, AK, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Borgatti, M | 1 |
| Chilin, A | 1 |
| Piccagli, L | 1 |
| Lampronti, I | 1 |
| Bianchi, N | 1 |
| Mancini, I | 1 |
| Marzaro, G | 1 |
| dall'Acqua, F | 1 |
| Guiotto, A | 1 |
| Gambari, R | 1 |
| Devor, DC | 1 |
| Singh, AK | 1 |
| Bridges, RJ | 1 |
| Frizzell, RA | 1 |
2 other studies available for trioxsalen and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: design, synthesis and biological effects.
Topics: Cell Line; Cystic Fibrosis; DNA; Drug Design; Furocoumarins; Gene Expression Regulation; Humans; Int | 2011 |
Psoralens: novel modulators of Cl- secretion.
Topics: Animals; Atropine; Benzimidazoles; Calcium; Carbachol; Cell Line; Chloride Channels; Chlorides; Chlo | 1997 |