trioxsalen has been researched along with Carcinoma, Squamous Cell in 2 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited." | 7.70 | Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999) |
| "It has been suggested that trioxsalen bath and ultraviolet (UV) A (PUVA) is associated with a very low or no risk of non-melanoma skin cancer, but the numbers of patients in individual studies have been limited." | 3.70 | Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. ( Berne, B; Hannuksela, M; Hannuksela-Svahn, A; Karvonen, J; Lindelöf, B; Poikolainen, K; Pukkala, E; Sigurgeirsson, B, 1999) |
| "A total of 18 squamous cell carcinomas of the skin were reported in 2975 PUVA-treated patients until 1987." | 1.28 | Comparison of the carcinogenic potential of trioxsalen bath PUVA and oral methoxsalen PUVA. A preliminary report. ( Berne, B; Larkö, O; Lindelöf, B; Sigurgeirsson, B; Tegner, E, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hannuksela-Svahn, A | 1 |
| Sigurgeirsson, B | 2 |
| Pukkala, E | 1 |
| Lindelöf, B | 2 |
| Berne, B | 2 |
| Hannuksela, M | 1 |
| Poikolainen, K | 1 |
| Karvonen, J | 1 |
| Tegner, E | 1 |
| Larkö, O | 1 |
2 other studies available for trioxsalen and Carcinoma, Squamous Cell
| Article | Year |
|---|---|
Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Confidence Intervals; Female; | 1999 |
Comparison of the carcinogenic potential of trioxsalen bath PUVA and oral methoxsalen PUVA. A preliminary report.
Topics: Administration, Oral; Adult; Carcinoma, Squamous Cell; Female; Humans; Male; Methoxsalen; PUVA Thera | 1992 |