trioxsalen and Aging
trioxsalen has been researched along with Aging in 2 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " Using Caenorhabditis elegans mutants, we identify DNA repair factors that protect against the genotoxicity of ICLs generated by trioxsalen/ultraviolet A (TMP/UVA) during development and aging." | 3.85 | Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. ( Rieckher, M; Schumacher, B; Williams, AB; Wilson, DM, 2017) |
Research
Studies (2)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Wilson, DM | 1 |
| Rieckher, M | 1 |
| Williams, AB | 1 |
| Schumacher, B | 1 |
| Hall, JD | 1 |
| Almy, RE | 1 |
| Scherer, KL | 1 |
Other Studies
2 other studies available for trioxsalen and Aging
| Article | Year |
|---|---|
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; DNA; DNA Repair; Female; Ho | 2017 |
DNA repair in cultured human fibroblasts does not decline with donor age.
Topics: Aged; Aging; Caffeine; Cell Line; Child, Preschool; DNA Repair; DNA, Viral; Fibroblasts; Humans; Inf | 1982 |