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trioxsalen and Aging

trioxsalen has been researched along with Aging in 2 studies

Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
" Using Caenorhabditis elegans mutants, we identify DNA repair factors that protect against the genotoxicity of ICLs generated by trioxsalen/ultraviolet A (TMP/UVA) during development and aging."3.85Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. ( Rieckher, M; Schumacher, B; Williams, AB; Wilson, DM, 2017)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wilson, DM1
Rieckher, M1
Williams, AB1
Schumacher, B1
Hall, JD1
Almy, RE1
Scherer, KL1

Other Studies

2 other studies available for trioxsalen and Aging

ArticleYear
Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans.
    Nucleic acids research, 2017, Sep-19, Volume: 45, Issue:16

    Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; DNA; DNA Repair; Female; Ho

2017
DNA repair in cultured human fibroblasts does not decline with donor age.
    Experimental cell research, 1982, Volume: 139, Issue:2

    Topics: Aged; Aging; Caffeine; Cell Line; Child, Preschool; DNA Repair; DNA, Viral; Fibroblasts; Humans; Inf

1982