trioxsalen has been researched along with Actinic Reticuloid Syndrome in 16 studies
Trioxsalen: Pigmenting photosensitizing agent obtained from several plants, mainly Psoralea corylifolia. It is administered either topically or orally in conjunction with ultraviolet light in the treatment of vitiligo.
lactone : Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring.
antipsoriatic : A drug used to treat psoriasis.
trioxsalen : 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The various drug dosage schedules investigated included 9 groups: 0." | 2.65 | Safety and therapeutic effectiveness of 8-methoxypsoralen, 4,5',8-trimethylpsoralen, and psoralen in vitiligo. ( Fitzpatrick, TB; Mosher, DB; Pathak, MA, 1984) |
| "The basic aspects of cutaneous photosensitization reactions and the mode of therapeutic effectiveness of psoralens used extensively in the photochemotherapy of psoriasis and vitiligo have been reviewed." | 1.27 | Mechanisms of psoralen photosensitization reactions. ( Pathak, MA, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (93.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jansén, CT | 2 |
| Karvonen, J | 1 |
| Malmiharju, T | 1 |
| Koulu, L | 1 |
| Pathak, MA | 3 |
| Mosher, DB | 1 |
| Fitzpatrick, TB | 1 |
| Kenney, JA | 1 |
| Grimes, PE | 1 |
| Marciani, MS | 1 |
| Guiotto, A | 1 |
| Rodighiero, G | 1 |
| Willis, I | 1 |
| Jillson, OF | 1 |
| Birt, AR | 2 |
| Berg, M | 1 |
| Ros, AM | 2 |
| Berne, B | 1 |
| Ljunggren, B | 1 |
| Jonelis, FJ | 1 |
| Epstein, JH | 1 |
| Martin, G | 1 |
| Davis, RA | 1 |
| Wennersten, G | 1 |
| Baran, R | 1 |
| Juhlin, L | 1 |
| Hönigsmann, H | 1 |
2 reviews available for trioxsalen and Actinic Reticuloid Syndrome
| Article | Year |
|---|---|
Hereditary polymorphic light eruption of American Indians.
Topics: Adolescent; Adult; Central America; Child; Child, Preschool; Eczema; Female; Humans; Indians, North | 1975 |
Psoralen photochemotherapy--mechanisms, drugs, toxicity.
Topics: DNA; Erythema; Furocoumarins; Humans; Methoxsalen; Neoplasms, Radiation-Induced; Photosensitivity Di | 1986 |
4 trials available for trioxsalen and Actinic Reticuloid Syndrome
| Article | Year |
|---|---|
PUVA therapy for polymorphous light eruptions: comparison of systemic methoxsalen and topical trioxsalen regimens and evaluation of local protective mechanisms.
Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Aged; Baths; Chronic Disease; Drug | 1982 |
Skin photosensitizing and Langerhans' cell depleting activity of topical (bath) PUVA therapy: comparison of trimethylpsoralen and 8-methoxypsoralen.
Topics: Adult; Cell Count; Female; Furocoumarins; Humans; Langerhans Cells; Male; Methoxsalen; Photochemothe | 1983 |
Safety and therapeutic effectiveness of 8-methoxypsoralen, 4,5',8-trimethylpsoralen, and psoralen in vitiligo.
Topics: Ficusin; Follow-Up Studies; Furocoumarins; Humans; Melanins; Methoxsalen; Photochemotherapy; Photose | 1984 |
Ultraviolet A phototherapy and trimethylpsoralen UVA photochemotherapy in polymorphous light eruption--a controlled study.
Topics: Adult; Double-Blind Method; Erythema; Female; Humans; Male; Middle Aged; Photochemotherapy; Photosen | 1994 |
10 other studies available for trioxsalen and Actinic Reticuloid Syndrome
| Article | Year |
|---|---|
Mechanisms of psoralen photosensitization reactions.
Topics: DNA; Furocoumarins; Humans; Methoxsalen; Oxygen; Photochemistry; Photosensitivity Disorders; Singlet | 1984 |
How we treat vitiligo.
Topics: Administration, Oral; Administration, Topical; Child; Furocoumarins; Humans; Hydroquinones; Methods; | 1983 |
A study of the relationship between photosensitizing and therapeutic activity of 4,5',8-trimethylpsoralen, and its major metabolite 4,8-dimethyl, 5'-carboxypsoralen.
Topics: Animals; DNA; Female; Furocoumarins; Guinea Pigs; Humans; Male; Methoxsalen; Mice; Photochemistry; P | 1983 |
Photochemotherapy: a new promising chemical derivative.
Topics: Animals; Furocoumarins; Guinea Pigs; Mice; Mice, Hairless; Photochemotherapy; Photosensitivity Disor | 1982 |
Treatment of polymorphous light eruption with Trisoralen and natural sunlight.
Topics: Furocoumarins; Humans; Photochemotherapy; Photosensitivity Disorders; Sunlight; Trioxsalen | 1981 |
Polymorphous light eruption.
Topics: Administration, Oral; Furocoumarins; Humans; Indians, North American; Photosensitivity Disorders; Tr | 1981 |
Psoralen photoallergy caused by plant contact.
Topics: Coumarins; Dermatitis, Contact; Ficusin; Humans; Male; Methoxsalen; Middle Aged; Photosensitivity Di | 1977 |
Letter: The safety of psoralens.
Topics: Adult; Coumarins; Humans; Male; Photosensitivity Disorders; Pigmentation; Sunburn; Trioxsalen | 1976 |
PUVA therapy for photosensitive psoriasis.
Topics: Female; Humans; Male; Methoxsalen; Middle Aged; Photosensitivity Disorders; Psoriasis; PUVA Therapy; | 1987 |
Drug-induced photo-onycholysis. Three subtypes identified in a study of 15 cases.
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Child; Doxycycline; Drug Eruptions; Female; H | 1987 |