triolein and Neoplasms

A triglyceride analog, glycerol-2-palmitoyl-1,3-di-15-(p-iodophenyl)pentadecanoate (DPPG) was synthesized and radiolabeled for evaluation as a potential functional liver scintigraphic agent. Uptake of DPPG was compared in normal, diabetic, tumor-bearing and heparin pretreated rats, revealing differences in uptake and clearance of radioactivity, correlating with hepatic lipase activity of these groups. Similar results were observed by gamma-camera scintigraphy. Comparing the uptake of DPPG with that of its fatty acid component, 15-(p-iodophenyl)pentadecanoic acid (IPPA), revealed that the peak uptake of IPPA in the liver was about half that of DPPG. Based upon these findings, DPPG warrants further study as a hepatic radiodiagnostic agent.

Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Evaluation Studies as Topic; Female; Gamma Cameras; Humans; Iodine Radioisotopes; Iodobenzenes; Lipase; Lipoproteins; Liver; Models, Biological; Neoplasms; Phosphatidylglycerols; Radionuclide Imaging; Rats; Rats, Inbred Strains; Tissue Distribution; Triglycerides; Triolein

Tumour necrosis factor alpha (cachectin) was administered to virgin, lactating and litter-removed rats, and subsequent disposal of an oral [1-14C]triolein (glycerol tri[1-14C]oleate) load examined. Absorption of the lipid and 14CO2 production were significantly depressed in all three groups. [14C]Lipid accumulation was decreased in carcass, liver and adipose tissue (brown and white) of virgin and litter-removed rats and the mammary gland of lactating rats. The plasma triacylglycerol concentration was increased in all three groups, and lipoprotein lipase activity was decreased in the white adipose tissue of virgin and litter-removed animals and in the mammary gland of lactating animals. Some, but not all, of these effects mimic tumour burden in the same physiological states [Evans & Williamson (1988) Biochem. J. 252, 65-72].

Topics: Adipose Tissue; Animals; Female; Hypertriglyceridemia; Lactation; Lipoprotein Lipase; Mammary Glands, Animal; Neoplasms; Pregnancy; Rats; Rats, Inbred Strains; Triolein; Tumor Necrosis Factor-alpha

Topics: Blood Volume Determination; Cobalt Isotopes; Cold Temperature; Corrinoids; Hematinics; Humans; Neoplasms; Phosphorus Isotopes; Radioisotopes; Radionuclide Imaging; Radiotherapy; Thyroid Function Tests; Triiodothyronine; Triolein; Vitamin B 12

Topics: Absorption; Carcinoma; Carcinoma 256, Walker; Fats; Intestinal Absorption; Intestines; Iodine Isotopes; Lipid Metabolism; Lymph; Neoplasms; Rats; Research; Thoracic Duct; Triolein

Topics: Calculi; Fatty Acids; Iodine Isotopes; Metabolism; Neoplasms; Oleic Acid; Pancreas; Pancreatic Cyst; Pancreatic Neoplasms; Pancreatitis; Radiometry; Triolein

Topics: Intestine, Small; Intestines; Neomycin; Neoplasms; Radiometry; Syndrome; Triolein