triolein and Hypertension

triolein has been researched along with Hypertension* in 4 studies

Trials

1 trial(s) available for triolein and Hypertension

Article	Year
Effects of hydrochlorothiazide and propranolol treatment on chylomicron metabolism in hypertensive objects. Canadian journal of physiology and pharmacology, 2005, Volume: 83, Issue:7 Modifications in chylomicron metabolism caused by antihypertensive drugs were investigated in hypertensive subjects because previous studies had indicated that diuretics and beta-blockers modify the plasma lipid concentrations through mechanisms that were not fully understood. A triglyceride-rich emulsion resembling lymph chylomicrons, labeled with (3H) triolein and (14C) cholesteryl oleate, was infused intravenously into mildly hypertensive patients after 8 weeks on placebo and subsequently on hydrochlorothiazide (n = 10) or propranolol (n = 8). The residence time of both radioactivities in plasma was utilized for the simultaneous calculation of the particle remnant removal rate and of the lipoprotein lipase activity expressed as a delipidation index = 1 - [(3H) triolein residence time/(14C) cholesteryl oleate residence time]. Treatment with hydrochlorothiazide diminished the delipidation rate value whereas propranolol mildly increased the removal rate of the remnant particle. These alterations of the chylomicron kinetics were not accompanied by changes in plasma triglycerides, glucose, and insulin concentration as measured in the fasting state. The impairment of the lipoprotein lipase activity by thiazides and the faster removal rate of the whole particle by propranolol could explain the reason why in previous clinical studies the simultaneous use of these drugs does not aggravate the hyperlipidemia known to be induced by thiazides alone. Topics: Adult; Aged; Antihypertensive Agents; Cholesterol Esters; Chylomicrons; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins, VLDL; Male; Middle Aged; Propranolol; Triolein	2005

Article

Year

Effects of hydrochlorothiazide and propranolol treatment on chylomicron metabolism in hypertensive objects.

Canadian journal of physiology and pharmacology, 2005, Volume: 83, Issue:7

Modifications in chylomicron metabolism caused by antihypertensive drugs were investigated in hypertensive subjects because previous studies had indicated that diuretics and beta-blockers modify the plasma lipid concentrations through mechanisms that were not fully understood. A triglyceride-rich emulsion resembling lymph chylomicrons, labeled with (3H) triolein and (14C) cholesteryl oleate, was infused intravenously into mildly hypertensive patients after 8 weeks on placebo and subsequently on hydrochlorothiazide (n = 10) or propranolol (n = 8). The residence time of both radioactivities in plasma was utilized for the simultaneous calculation of the particle remnant removal rate and of the lipoprotein lipase activity expressed as a delipidation index = 1 - [(3H) triolein residence time/(14C) cholesteryl oleate residence time]. Treatment with hydrochlorothiazide diminished the delipidation rate value whereas propranolol mildly increased the removal rate of the remnant particle. These alterations of the chylomicron kinetics were not accompanied by changes in plasma triglycerides, glucose, and insulin concentration as measured in the fasting state. The impairment of the lipoprotein lipase activity by thiazides and the faster removal rate of the whole particle by propranolol could explain the reason why in previous clinical studies the simultaneous use of these drugs does not aggravate the hyperlipidemia known to be induced by thiazides alone.

Topics: Adult; Aged; Antihypertensive Agents; Cholesterol Esters; Chylomicrons; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins, VLDL; Male; Middle Aged; Propranolol; Triolein

2005

Other Studies

3 other study(ies) available for triolein and Hypertension

Article	Year
Experimental cerebral fat embolism. Distribution of radioactive triolein following internal carotid introduction. Archives of neurology, 1971, Volume: 24, Issue:5 Topics: Animals; Brain; Brain Stem; Carotid Arteries; Cheyne-Stokes Respiration; Choroid Plexus; Embolism, Fat; Eye; Hypertension; Injections, Intra-Arterial; Intracranial Embolism and Thrombosis; Iodine Isotopes; Ischemic Attack, Transient; Lung; Mesencephalon; Pons; Pulmonary Embolism; Rabbits; Spasm; Triolein; Vascular Diseases	1971
[ON THE INCIDENCE OF LIPEMIA CLEARING INSUFFICIENCY IN VARIOUS DISEASES]. Deutsches medizinisches Journal, 1964, Jan-20, Volume: 15 Topics: Arteriosclerosis; Blood Circulation Time; Carbohydrate Metabolism; Chylomicrons; Coronary Disease; Diabetes Mellitus; Humans; Hyperlipidemias; Hypertension; Incidence; Iodine Isotopes; Lipoprotein Lipase; Obesity; Triolein	1964
[STUDIES ON THE INFLUENCING OF FAT CLEARANCE IN VIVO]. Deutsches medizinisches Journal, 1964, Feb-05, Volume: 15 Topics: Adenosine Triphosphate; Arteriosclerosis; Dietary Fats; Heparin; Hyperlipidemias; Hypertension; Iodine Isotopes; Niacin; Obesity; Triolein	1964